User:DavidDrubin

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Biographical Info

david_drubin at hms dot harvard dot edu

-3rd year Postdoctoral Research Fellow

-Ph.D. Integrative Biosciences-Molecular Medicine, Penn State University College of Medicine, 2004

    Graduate Advisor:  Dr. Gary A. Clawson, Clawson lab, Jake Gittlen Cancer Research Institute
    Research Topic:  Early changes in carcinogenesis

-B.S. Biochemistry and Molecular Biology, University of Massachusetts at Amherst, 1997

    Honors Advisor:  Dr. Maurille "Skip" J. Fournier
    Research Topic:  snoRNA biogenesis

Research Interests

We (with students Jake and Bill and the gracious help of the rest of the synthetic biology team) are pursuing the design and construction of a cell-based, multi-plex sensor-memory device. Such a device will be able to report whether specific events occur in a cell or whether certain compounds are present in the cell's environment. Furthermore, such a system is also designed to report on how much of a thing the system is sensing, and storing such information in itself as well as its descendants. A key feature of such a system will also be its portability to various environmental stimuli/cellular events.

Publications

Drubin, DA, Garakani, AM, and Silver, PA. (2006). Motion as a phenotype: the use of live-cell imaging and machine visual screening to characterize transcription-dependent chromosome dynamics. BMC Cell Biology 7: 19.

Dhamne C, Drubin DA, Duncan K, Tevethia MJ, Clawson GA. (2006) The chloromethylketone protease inhibitor AAPF(CMK) also targets ATP-dependent helicases and SAP-domain proteins. J Cell Biochem

Drubin, DA*, McLaughlin-Drubin, ME*, Clawson, GA, and Meyers, C. (2006). A Protease Inhibitor Specifically Inhibits Growth of HPV Infected Tissue. Molecular Therapy 13(6): 1142-8. *authors equally contributed to this work.

Casolari, JM, Brown, CR, Drubin, DA, Rando, OJ and Silver, PA. (2005). Developmentally Induced Changes in Transcriptional Program Alter Spatial Organization Across Chromosomes. Genes and Development 19: 1188-1198.

Drubin, DA, Smith, JS, Liu, W, Zhao, W, Chase, GA, and Clawson, GA. (2005). Comparison of Cryopreservation and Standard Needle Biopsy for Gene Expression Profiling of Human Breast Cancer Specimens. Breast Cancer Research and Treatment 90: 93-96.

Drubin, DA and Clawson, GA (2004). Spontaneous transformation of an immortalized hepatocyte cell line: potential role of a nuclear protease. Cancer Letters 213: 39-48.

G. Clawson, D. Drubin, M. McLaughlin-Drubin, C. Meyers. “A Nuclear Protease Inhibitor as a Topical Therapeutic for Cervical Dysplasias”, patent pending.