User:Claus O. Wilke

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Contact Info

Claus O. Wilke
  • Claus O. Wilke
  • Section of Integrative Biology, Center for Computational Biology and Bioinformatics, and Institute for Cell and Molecular Biology
  • The University of Texas at Austin, Austin, TX 78712
  • Wilke lab
  • Email me through OpenWetWare


  • 1999, PhD, Ruhr-University Bochum, Germany
  • 1996, Diplom, Ruhr-University Bochum, Germany

Research interests

  1. Computational evolutionary biology
  2. Molecular evolution
  3. Virus evolution

Selected Publications

  1. Steinmeyer SH and Wilke CO. Lethal mutagenesis in a structured environment. J Theor Biol. 2009 Nov 7;261(1):67-73. DOI:10.1016/j.jtbi.2009.07.014 | PubMed ID:19627995 | HubMed [Steinmeyer_Wilke_2009]
  2. Brennan TP, Woods JO, Sedaghat AR, Siliciano JD, Siliciano RF, and Wilke CO. Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy. J Virol. 2009 Sep;83(17):8470-81. DOI:10.1128/JVI.02568-08 | PubMed ID:19535437 | HubMed [Brennan_et_al_2009]
  3. Sedaghat AR, Siliciano RF, and Wilke CO. Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir. Antivir Ther. 2009;14(2):263-71. PubMed ID:19430101 | HubMed [Sedaghat_et_al_2009]
  4. Zhou T, Weems M, and Wilke CO. Translationally optimal codons associate with structurally sensitive sites in proteins. Mol Biol Evol. 2009 Jul;26(7):1571-80. DOI:10.1093/molbev/msp070 | PubMed ID:19349643 | HubMed [Zhou_et_al_2009]
  5. Zhou T, Enyeart PJ, and Wilke CO. Detecting clusters of mutations. PLoS One. 2008;3(11):e3765. DOI:10.1371/journal.pone.0003765 | PubMed ID:19018282 | HubMed [Zhou_et_al_2008b]
  6. Novella IS, Dutta RN, and Wilke CO. A linear relationship between fitness and the logarithm of the critical bottleneck size in vesicular stomatitis virus populations. J Virol. 2008 Dec;82(24):12589-90. DOI:10.1128/JVI.01394-08 | PubMed ID:18829755 | HubMed [Novella_et_al_2008]
  7. Bull JJ and Wilke CO. Lethal mutagenesis of bacteria. Genetics. 2008 Oct;180(2):1061-70. DOI:10.1534/genetics.108.091413 | PubMed ID:18780744 | HubMed [Bull_Wilke_2008]
  8. Drummond DA and Wilke CO. Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell. 2008 Jul 25;134(2):341-52. DOI:10.1016/j.cell.2008.05.042 | PubMed ID:18662548 | HubMed [Drummond_Wilke_2008]
  9. Brunet E, Rouzine IM, and Wilke CO. The stochastic edge in adaptive evolution. Genetics. 2008 May;179(1):603-20. DOI:10.1534/genetics.107.079319 | PubMed ID:18493075 | HubMed [Brunet_et_al_2008]
  10. Whitehead DJ, Wilke CO, Vernazobres D, and Bornberg-Bauer E. The look-ahead effect of phenotypic mutations. Biol Direct. 2008 May 14;3:18. DOI:10.1186/1745-6150-3-18 | PubMed ID:18479505 | HubMed [Whitehead_et_al_2008]
  11. Zhou T, Drummond DA, and Wilke CO. Contact density affects protein evolutionary rate from bacteria to animals. J Mol Evol. 2008 Apr;66(4):395-404. DOI:10.1007/s00239-008-9094-4 | PubMed ID:18379715 | HubMed [Zhou_et_al_2008a]
  12. Sedaghat AR, Dinoso JB, Shen L, Wilke CO, and Siliciano RF. Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4832-7. DOI:10.1073/pnas.0711372105 | PubMed ID:18362342 | HubMed [Sedaghat_et_al_2008b]
  13. Dutta RN, Rouzine IM, Smith SD, Wilke CO, and Novella IS. Rapid adaptive amplification of preexisting variation in an RNA virus. J Virol. 2008 May;82(9):4354-62. DOI:10.1128/JVI.02446-07 | PubMed ID:18287227 | HubMed [Dutta_et_al_2008]
  14. Sedaghat AR, Siliciano RF, and Wilke CO. Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART. BMC Infect Dis. 2008 Jan 2;8:2. DOI:10.1186/1471-2334-8-2 | PubMed ID:18171475 | HubMed [Sedaghat_et_al_2008a]
  15. Rouzine IM, Brunet E, and Wilke CO. The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation. Theor Popul Biol. 2008 Feb;73(1):24-46. DOI:10.1016/j.tpb.2007.10.004 | PubMed ID:18023832 | HubMed [Rouzine_et_al_2008]

All Medline abstracts: PubMed | HubMed