- Graduate Student at OHSU (See "Current" below)
- 2003-04, a BioMedical Staff Scientist in the BBRP (now the Physical and Life Sciences Directorate) at Lawrence Livermore National Laboratory.
Student in OHSU's MD/PhD Program (Final year: MS4)
I study the regulation of a gene called RGMc (also called Hemojuvelin (HJV) in humans). RGMc/HJV plays a critical role in iron metabolism, as inactivating mutations cause juvenile hemochromatosis, a severe iron overload disorder.
The long-range goals of my research are to enhance understanding of the molecular mechanisms by which evolution has shaped the regulation of gene expression in a family of genes, and apply this knowledge to understand select human diseases.
The primary focus of my research is three-fold:
(1) to understand the genomic structure of the Repulsive Guidance Molecule (RGM) family,
(2) to understand the mechanisms of transcriptional regulation of RGMc,
(3) to understand the basics of the molecular evolution of the RGM family.
An interactive Molecular Model of the RGM-family at the protein level
For the Transcriptional Regulation of RGMc, see this 2010 article in Genomics.
More Coming soon!
General Scientific Links (a.k.a., Teaching Science in the Community):
- Understanding Evolution and why its so important to health, disease, and our fundamental understanding of biology.
- Learn Genetics with videos and interactive lessons.
- Introduction to X-ray Crystallography. An easy to understand video going from cells to structure.
- "Mini Med-School" lecture by Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology, explores the damage caused by sugary foods. He argues that (too much) fructose and (not enough) fiber appear to be cornerstones of the obesity epidemic through their effects on insulin. Series: UCSF Mini Medical School for the Public (7/2009; Health and Medicine, Show ID: 16717)
- Tree of Life web project about biodiversity.
- Learn about RNAi and gene regulation, with "a petunia, Pirate Ships, little Chefs, and 'the Cop'." (Intrigued? Click on the link and watch the video)
- The Powers of 10 expolores the range of sizes in our world, and our perspective in it. “We find that we inhabit an insignificant planet of a hum-drum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.” -Carl Sagan
All Publications for C.J. Severyn on NCBI-PubMed
ResearcherID Link for C. Severyn
1. Molecular biology, genetics and biochemistry of the repulsive guidance molecule family.
C. J. Severyn, U. Shinde and P. Rotwein, Biochem. J. (2009) v422:393-403 
2. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle.
C. J. Severyn and P. Rotwein, Genomics (2010) v96:342–351 
email: severync AT ohsu DOT edu
- OHSU Cameras in Portland, OR
- A web-based version to plan your visit to one of "America's Best Idea"
- And more views from the webcams at Yosemite National Park
- Or the eastern side of the Sierra Nevada with Mono Lake
- Packard Kids Connection @ LPCH, a great interactive site explaining select medical procedures to children and their parents (in English or Spanish), along with the “Power Penguin.”
- Children's Hospital Boston, including the literature character "Arthur's Guide" to Children's Hospital.
Course Web Pages
OHSU 2007 Course: Adv. Topics in Molecular Biology
Discussion Questions and Presentations: Chris