User:Chris: Difference between revisions
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{{Template:Chris}} | {{Template:Chris}} | ||
== | ==Education== | ||
Major: [http://mcb.berkeley.edu/ Molecular & Cell Biology] at the | *Undergraduate Major: [http://mcb.berkeley.edu/ Molecular & Cell Biology] at the [http://www.berkeley.edu/ Univ. of California, Berkeley] | ||
[http://www.berkeley.edu/ Univ. of California, Berkeley] | [[Image:Berkeley_2006_Sather_Tower.JPG|thumb|250px]] | ||
[[Image: | |||
*Graduate School: Ph.D. Biochemistry and Molecular Biology completed in the [http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/basic-science-departments/biochemistry-molecular-biology/faculty/rotwein.cfm Rotwein Lab] of the [http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/basic-science-departments/biochemistry-molecular-biology/ Dep't of Biochemistry & Molecular Biology] at [http://www.ohsu.edu Oregon Health & Science Univ.] | |||
*Medical School: (in progress) Student in [http://www.ohsu.edu/mdphd/ OHSU's MD/PhD Program] (Final year: MS4) | |||
==Research== | ==Research== | ||
* | * 2003-04, a BioMedical Staff Scientist in the BBRP (now the [http://www-pls.llnl.gov/ Physical and Life Sciences Directorate]) at [http://www.llnl.gov/ Lawrence Livermore National Laboratory]. | ||
* 2005-2010 Graduate Student at OHSU | |||
'''Research Interests''': | |||
I study the regulation of a gene called '''RGMc''' (also called Hemojuvelin (HJV) in humans). RGMc/HJV plays a critical role in iron metabolism, as inactivating mutations cause juvenile hemochromatosis, a severe iron overload disorder. | |||
The ''long-range goals'' of my research are to enhance understanding of the molecular mechanisms by which evolution has shaped the regulation of gene expression in a family of genes, and apply this knowledge to understand select human diseases. | |||
The primary focus of my research is three-fold: | |||
'''(1)''' to understand the genomic structure of the Repulsive Guidance Molecule (RGM) family, | |||
'''(2)''' to understand the mechanisms of transcriptional regulation of RGMc, | |||
'''(3)''' to understand the basics of the molecular evolution of the RGM family. | |||
An interactive [http://www.biochemj.org/bj/422/0393/bj4220393add.htm Molecular Model of the RGM-family] at the protein level | |||
For the Transcriptional Regulation of RGMc, see this [http://www.ncbi.nlm.nih.gov/pubmed/20858542 2010 article in ''Genomics'']. | |||
''More Coming soon!'' | |||
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* Learn about [http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html '''RNAi and gene regulation'''], with "a petunia, Pirate Ships, little Chefs, and 'the Cop'." (Intrigued? Click on the link and watch the video) | * Learn about [http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html '''RNAi and gene regulation'''], with "a petunia, Pirate Ships, little Chefs, and 'the Cop'." (Intrigued? Click on the link and watch the video) | ||
* Want to know what Nanotechnology is? Find out in three minutes with the [http://www.youtube.com/watch?v=LFoC-uxRqCg Nanosong] by students at Cal. | |||
* [http://www.powersof10.com/ The Powers of 10] expolores the range of sizes in our world, and our perspective in it. “We find that we inhabit an insignificant planet of a hum-drum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.” -Carl Sagan | * [http://www.powersof10.com/ The Powers of 10] expolores the range of sizes in our world, and our perspective in it. “We find that we inhabit an insignificant planet of a hum-drum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.” -Carl Sagan | ||
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1. Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. | 1. Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. | ||
'''C. J. Severyn''', U. Shinde and P. Rotwein, '''Biochem. J.''' ''(2009)'' v422:393-403 [http://tinyurl.com/lcylrp] | '''C. J. Severyn''', U. Shinde and P. Rotwein, '''Biochem. J.''' ''(2009)'' v422:393-403 [http://tinyurl.com/lcylrp] | ||
2. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin gene transcription in skeletal muscle. '''C. J. Severyn''' and P. Rotwein, '''Genomics''' ''(2010)'' | 2. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle. | ||
'''C. J. Severyn''' and P. Rotwein, '''Genomics''' ''(2010)'' v96:342–351 [http://www.ncbi.nlm.nih.gov/pubmed/20858542] | |||
==Contact== | ==Contact== | ||
email: severync AT ohsu DOT edu | email: severync AT ohsu DOT edu | ||
==Photography== | |||
See some of my [http://openwetware.org/wiki/User:Chris_Photography photographs] including this image of Mount Hood in Oregon: | |||
[[Image:Mount_Hood_Alpenglow.JPG|thumb|500px]] | |||
==WebCams and other links== | ==WebCams and other links== | ||
* [http://scienceview.berkeley.edu/view/ “The View” from the hills of the Greatest University in the World] | * [http://scienceview.berkeley.edu/view/ “The View” from the hills of the Greatest University in the World] | ||
* [http://www.ohsu.edu/xd/about/visiting/directions/cams.cfm OHSU Cameras] in Portland, OR | |||
* [http://www.montereybayaquarium.org/efc/cam_menu.asp Monterey Bay Aquarium Web-Cams] | * [http://www.montereybayaquarium.org/efc/cam_menu.asp Monterey Bay Aquarium Web-Cams] | ||
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* Or the eastern side of the Sierra Nevada with [http://www.monolake.org/today/webcam Mono Lake] | * Or the eastern side of the Sierra Nevada with [http://www.monolake.org/today/webcam Mono Lake] | ||
* A time-lapse video of one of the [http://vimeo.com/35396305 greatest locations] on the planet | |||
* [http://www.eastbaychildrensbookproject.org/ East Bay Children’s Book Project] | '''Organizations and links to Pediatric Health Care''' | ||
* [http://www.ohsu.edu/xd/health/services/doernbecher/index.cfm Doernbecher Children’s Hospital] @ OHSU | |||
* A great App from Doernbecher for parents: [http://itunes.apple.com/app/md-4kids/id417559754?mt=8 iPhone MD4Kids] (or [https://play.google.com/store/apps/details?id=com.gss.android.MD4KIDS MD4kids android devices]) | |||
* Helping Children love books from the start with [http://www.eastbaychildrensbookproject.org/ East Bay Children’s Book Project] and the National [http://www.reachoutandread.org/ Reach out and Read] program. | |||
* [http://www.ucsfhealth.org/childrens/index.html UCSF Children’s Hospital] | * [http://www.ucsfhealth.org/childrens/index.html UCSF Children’s Hospital] | ||
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* [http://www.lpch.org/kids/index.html Packard Kids Connection] @ LPCH, a great interactive site explaining select medical procedures to children and their parents (in English or Spanish), along with the “Power Penguin.” | * [http://www.lpch.org/kids/index.html Packard Kids Connection] @ LPCH, a great interactive site explaining select medical procedures to children and their parents (in English or Spanish), along with the “Power Penguin.” | ||
* [http://www.seattlechildrens.org/ Seattle Children’s Hospital] and SCH's on-line [http://www.seattlechildrens.org/healthcare-professionals/education/online-grand-rounds/ Grand Rounds] | * [http://www.seattlechildrens.org/ Seattle Children’s Hospital] and SCH's on-line [http://www.seattlechildrens.org/healthcare-professionals/education/online-grand-rounds/ Grand Rounds] | ||
*[http://www.childrenshospital.org/ Children's Hospital Boston], including the literature character [http://www.childrenshospital.org/arthur/ "Arthur's Guide"] to Children's Hospital. | |||
*[http://www.aap.org The American Academy of Pediatrics] including [http://pedsinreview.aappublications.org/ Pediatrics in Review] | |||
[http://www. | |||
==Course Web Pages== | ==Course Web Pages== | ||
Revision as of 09:29, 30 September 2012
Education
- Undergraduate Major: Molecular & Cell Biology at the Univ. of California, Berkeley
- Graduate School: Ph.D. Biochemistry and Molecular Biology completed in the Rotwein Lab of the Dep't of Biochemistry & Molecular Biology at Oregon Health & Science Univ.
- Medical School: (in progress) Student in OHSU's MD/PhD Program (Final year: MS4)
Research
- 2003-04, a BioMedical Staff Scientist in the BBRP (now the Physical and Life Sciences Directorate) at Lawrence Livermore National Laboratory.
- 2005-2010 Graduate Student at OHSU
Research Interests:
I study the regulation of a gene called RGMc (also called Hemojuvelin (HJV) in humans). RGMc/HJV plays a critical role in iron metabolism, as inactivating mutations cause juvenile hemochromatosis, a severe iron overload disorder.
The long-range goals of my research are to enhance understanding of the molecular mechanisms by which evolution has shaped the regulation of gene expression in a family of genes, and apply this knowledge to understand select human diseases.
The primary focus of my research is three-fold:
(1) to understand the genomic structure of the Repulsive Guidance Molecule (RGM) family,
(2) to understand the mechanisms of transcriptional regulation of RGMc,
(3) to understand the basics of the molecular evolution of the RGM family.
An interactive Molecular Model of the RGM-family at the protein level
For the Transcriptional Regulation of RGMc, see this 2010 article in Genomics.
More Coming soon!
General Scientific Links (a.k.a., Teaching Science in the Community):
- Understanding Evolution and why its so important to health, disease, and our fundamental understanding of biology.
- Learn Genetics with videos and interactive lessons.
- Introduction to X-ray Crystallography. An easy to understand video going from cells to structure.
- "Mini Med-School" lecture by Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology, explores the damage caused by sugary foods. He argues that (too much) fructose and (not enough) fiber appear to be cornerstones of the obesity epidemic through their effects on insulin. Series: UCSF Mini Medical School for the Public (7/2009; Health and Medicine, Show ID: 16717)
- Tree of Life web project about biodiversity.
- Learn about RNAi and gene regulation, with "a petunia, Pirate Ships, little Chefs, and 'the Cop'." (Intrigued? Click on the link and watch the video)
- Want to know what Nanotechnology is? Find out in three minutes with the Nanosong by students at Cal.
- The Powers of 10 expolores the range of sizes in our world, and our perspective in it. “We find that we inhabit an insignificant planet of a hum-drum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.” -Carl Sagan
More soon!
Publications
All Publications for C.J. Severyn on NCBI-PubMed
ResearcherID Link for C. Severyn
1. Molecular biology, genetics and biochemistry of the repulsive guidance molecule family.
C. J. Severyn, U. Shinde and P. Rotwein, Biochem. J. (2009) v422:393-403 [1]
2. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle.
C. J. Severyn and P. Rotwein, Genomics (2010) v96:342–351 [2]
Contact
email: severync AT ohsu DOT edu
Photography
See some of my photographs including this image of Mount Hood in Oregon:
WebCams and other links
- OHSU Cameras in Portland, OR
- A web-based version to plan your visit to one of "America's Best Idea"
- And more views from the webcams at Yosemite National Park
- Or the eastern side of the Sierra Nevada with Mono Lake
- A time-lapse video of one of the greatest locations on the planet
Organizations and links to Pediatric Health Care
- A great App from Doernbecher for parents: iPhone MD4Kids (or MD4kids android devices)
- Helping Children love books from the start with East Bay Children’s Book Project and the National Reach out and Read program.
- Packard Kids Connection @ LPCH, a great interactive site explaining select medical procedures to children and their parents (in English or Spanish), along with the “Power Penguin.”
- Seattle Children’s Hospital and SCH's on-line Grand Rounds
- Children's Hospital Boston, including the literature character "Arthur's Guide" to Children's Hospital.
Course Web Pages
OHSU 2007 Course: Adv. Topics in Molecular Biology
Discussion Questions and Presentations: Chris
- DNA Replication Discussion Qsts
- Exon Junction Complex BMCB625:Exon_Jxn_Complex
- Link to Universal Template BMCB625:Discussion_Univ_template
- Mathematics in Biology BMCB625:Mathematics_in_Biology
