User:Carsten C. Mahrenholz

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Revision as of 06:11, 16 March 2009 by Carsten C. Mahrenholz (talk | contribs) (Communications and Talks)
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Contact Info

Carsten C. Mahrenholz (an artistic interpretation)
  • Carsten C. Mahrenholz
  • Molecular Libraries and Recognition Group
  • Charité Medical School

I work in the Institute of Medical Immunology at Charité Medical School. I've joined because Hopefully I can find some people to share information about my phd-topics (coiled-coils and SPOT-synthesis) and add some related methodical and input value.


  • since 2005, PhD student (Boichemistry)
             Institute of Medical Immunology, Charité Medical School, Berlin
  • 2001-2005, Dipl. Biol. (Molecular Biology, Biophysics, Immunology)
             Humboldt University, Berlin and 
             Gutenberg University, Mainz
  • 2006-2008, MBA (General Management - Dual Award)
             Berlin School of Economics and 
             Ashcroft International Business School, Cambridge

Research interests

  1. Coiled-Coil interaction, stoichometry and peptide design (We use biochemical high-throughput(SPOT- and Peptide-Synthesis) methods, biophysics (ITC, AUZ, Biacore) and informatics (SVM) to define the rules of association on the amino-acid level.)
  2. association landscapes for coiled-coil protein interaction
  3. evolution theory


  1. Mahrenholz CC and Portwich M. Peptides interacting with alpha-helical coiled-coil streuctures and/or coiled-coil sequences, substances derived therefrom, and use thereof (WO/2007/068240) [Patent1]
  2. Portwich M, Keller S, Strauss HM, Mahrenholz CC, Kretzschmar I, Kramer A, and Volkmer R. A network of coiled-coil associations derived from synthetic GCN4 leucine-zipper arrays. Angew Chem Int Ed Engl. 2007;46(10):1654-7. DOI:10.1002/anie.200603246 | PubMed ID:17211913 | HubMed [Paper1]
  3. Ay B, Streitz M, Boisguerin P, Schlosser A, Mahrenholz CC, Schuck SD, Kern F, and Volkmer R. Sorting and pooling strategy: a novel tool to map a virus proteome for CD8 T-cell epitopes. Biopolymers. 2007;88(1):64-75. DOI:10.1002/bip.20637 | PubMed ID:17117459 | HubMed [Paper2]
  4. Fidan Z*, Mahrenholz CC*, Portwich M, Volkmer R. Analyses of coiled-coil associations by SPOT technology. Chem Today 2008; 26(2) 28-32. [Paper3]
All Medline abstracts: PubMed | HubMed

Communications and Talks

  1. Mahrenholz CC, Schuck S, Kretzschmar I, Ay B, Volkmer R. An optimized SPOT synthesis protocol: High-throughput synthesis of peptides with authentic and free C-termini. Chem Bio Net (2005)
  2. Volkmer R, Portwich M, Strauss HM, Mahrenholz CC, Kretzschmar I, Keller, S. Analysis of coiled-coil associations by SPOT technology and biophysics. 8th German Peptide Symposium (2007)
  3. Mahrenholz CC, Promiscuous coiled-coils and their pharmacological potential. 6th Bionnale (2008)
  4. Abfalter IG*, Mahrenholz CC*, Bodenhofer U, Hochreiter S. Analyzing Coiled Coil Proteins With Support Vector Machines to Design New Anti-Viral Drugs. Intelligent Systems for Molecular Biology (2008)
  5. Mahrenholz CC, Tapia V, Stigler R, Volkmer R. Peptides crossreacting with detection systems – Analysis at the amino acid level. 9th Peptide Symposium (2009)
  6. Mahrenholz CC*, Abfalter IG*, Bodenhofer U, Volkmer R, Hochreiter S. Defining distinctive rules for stoichiometry and recognition of coiled coil proteins using bioinformatical methods. 9th Peptide Symposium (2009)

Useful links