User:Allison K. Alix/Notebook/CHEM-581/2013/01/30: Difference between revisions
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==Description== | ==Description== | ||
Currently the oral delivery of insulin is not possible, due to it's degradation in the stomach before reaching the bloodstream. This project will employ a hydrogel core (to begin synthesis today) which will ultimately be coated by a lipid bilayer. | |||
==Procedure== | ==Procedure== | ||
Revision as of 07:48, 6 February 2013
 Experimental Chemistry
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ObjectiveBegin hydrogel formation using freeze-thaw method for the design of a system that allows for the oral delivery of insulin. DescriptionCurrently the oral delivery of insulin is not possible, due to it's degradation in the stomach before reaching the bloodstream. This project will employ a hydrogel core (to begin synthesis today) which will ultimately be coated by a lipid bilayer. ProcedureDissolve 0.5g PVOH of the following molecular weights in 6mL of H2O @ 95°C : a) 22,000 (MP Biomedicals) b) 89,000-98,000 99+% hydrolysis(Aldrich Chemistry) c) 130,000 99+% hydrolysis(Aldrich Chemistry) d) 146,000-186,000 99+% hydrolysis(Aldrich Chemistry)
Data
Referenceshttp://jtc.sagepub.com/content/early/2011/12/26/0892705711430857.full.pdf+html http://www.kirj.ee/public/proceedings_pdf/2009/issue_1/proc-2009-1-63-66.pdf
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