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PUBLICATIONS 303. Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2020). Interplay of Adsorption, Supersaturation and the Presence of an Absorptive Sink on Drug Release from Mesoporous Silica-Based Formulations. Pharmaceutical Research. 37(8):163 1-18. http://dx.doi.org/10.1007/s11095-020-02879-9 302. Ueda, K., and Taylor, L. S. (2020). Impact of hypromellose acetate succinate grade on drug amorphous solubility and in vitro membrane transport. Journal of Pharmaceutical Sciences. 109(8): 2464-2473. http://dx.doi.org/10.1016/j.xphs.2020.04.014 301. McCarthy, C. A., Zemlyanov, D., Crean, A. M., Taylor, L. S. (2020). Comparison of Drug Release and Adsorption Under Supersaturating Conditions for Ordered Mesoporous Silica with Indomethacin or Indomethacin Methyl Ester. Molecular Pharmaceutics. 17(8): 3062–3074. http://dx.doi.org/10.1021/acs.molpharmaceut.0c00489 300. Enright, E. F., Joyce, S. A., Gahan, C. G. M., Taylor, L. S. (2020) Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions. European Journal of Pharmaceutics and Biopharmaceutics. 153: 68-83. http://dx.doi.org/10.1016/j.ejpb.2020.05.022 299. Parker, A. S., Taylor, L. S., and Beaudoin, S. P. (2020). The Role of Surface Energy Heterogeneity on Crystal Morphology during Solid-State Crystallization at the Amorphous Atazanavir-Water Interface. CrysEngComm. 22, 3179-3187. http://dx.doi.org/10.1039/C9CE02007A 298. Trasi, N. S., Bhujbal, S.V., Zhou, Q. T., and Taylor, L. S. (2020). Physical Stability and Release Properties of Lumefantrine Amorphous Solid Dispersion Granules Prepared by a Simple Solvent Evaporation Approach. International Journal of Pharmaceutical Sciences X, 100052. http://dx.doi.org/10.1016/j.ijpx.2020.100052 297. Que, C., Qi, Q., Zemlyanov, D. Y., Mo, H., Deac, A., Zeller, M., Indulkar, A. S., Gao, Y,. Zhang, G. G. Z., and Taylor, L. S. (2020). Evidence for Halogen Bonding in Amorphous Solid Dispersions. Crystal Growth and Design. 20 (5): 3224–3235. http://dx.doi.org/10.1021/acs.cgd.0c00073 296. Saboo, S. S., Kestur, U. S., Flaherty, D. P., Taylor, L. S. (2020) Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization and glass transition. Molecular Pharmaceutics. 17(4): 1261–1275. http://dx.doi.org/10.1021/acs.molpharmaceut.9b01272 295. Ueda, K., and Taylor, L. S. (2020). Polymer type impacts amorphous solubility and drug-rich phase colloidal stability: A mechanistic study using nuclear magnetic resonance spectroscopy. Molecular Pharmaceutics. 17(4):1352-1362 http://dx.doi.org/10.1021/acs.molpharmaceut.0c00061 294. Moseson, D.E., Parker, A.S., Beaudoin, S.P., and Taylor, L.S., (2020) Amorphous Solid Dispersions Containing Residual Crystallinity: Influence of Seed Properties and Polymer Adsorption on Dissolution Performance. European Journal of Pharmaceutical Sciences. 146: 105276. http://dx.doi.org/10.1016/j.ejps.2020.105276 293. Wilson, N.E., Mutukuri, T.T., Zemlyanov, D.Y., Taylor, L. S., Topp, E.M., Zhou, Q. T. (2020). Surface Composition and Formulation Heterogeneity of Protein Solids Produced by Spray Drying. Pharmaceutical Research. 37(1):14. http://dx.doi.org/10.1007/s11095-019-2738-9 292. Sherman, A. M., Geiger, A. C., Smith, C.,Taylor, L. S. Hinds, J., Stroud, P., Simpson, G. J. (2020). Stochastic Differential Scanning Calorimetry by Nonlinear Optical Microscopy. Analytical Chemistry. 92(1): 1171-1178. http://dx.doi.org/10.1021/acs.analchem.9b04300 291. Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2020). Absorptive dissolution testing: An improved approach to study the impact of residual crystallinity on the performance of amorphous formulations. Journal of Pharmaceutical Sciences. 109(3): 1312-1323. http://dx.doi.org/10.1016/j.xphs.2019.11.016. 290. Indulkar, A. S., Raina, S. A., Gao, Y., Zhang, G. G. Z., and Taylor, L. S. (2020). Impact of monomeric vs. micellar surfactant and surfactant-polymer interactions on nucleation-induction times of atazanavir from supersaturated solutions. Crystal Growth and Design. 20(1):62-72. http://dx.doi.org/10.1021/acs.cgd.9b00482 289. Trasi, N. S., Bhujbal, S.V., Zhou, Q. T., and Taylor, L. S. (2019). Amorphous Solid Dispersion Formation via Solvent Granulation – A Case Study with Ritonavir and Lopinavir. International Journal of Pharmaceutics. X 1, 100035. http://dx.doi.org/10.1016/j.ijpx.2019.100035 288. Que, C., Lou, X., Zemlyanov, D. Y., Mo, H., Indulkar, A. S., Gao, Y., Zhang, G. G. Z. and Taylor, L. S. (2019). Insights into the Dissolution Behavior of Ledipasvir-Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions. Molecular Pharmaceutics. 16(12):5054-5067. http://dx.doi.org/10.1021/acs.molpharmaceut.9b01025 287. Elkhabaz, A., Sarkar, S., Simpson, G. J., and Taylor, L.S. (2019). Characterization of Phase Transformations for Amorphous Solid Dispersions of a Weakly Basic Drug upon Dissolution in Biorelevant Media. Pharmaceutical Research. 36 (12), 174. http://dx.doi.org/10.1007/s11095-019-2718-0 286. Tres, F., Posada, M. M., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2019). The Effect of Promiscuous Aggregation on In Vitro Drug Metabolism Assays. Pharmaceutical Research. 36 (12), 170. http://dx.doi.org/10.1007/s11095-019-2713-5 285. Elkhabaz, A., Moseson, D. E., Brouwers, J., Augustijns, P., and Taylor, L.S. (2019). Interplay of supersaturation and solubilization: Lack of correlation between concentration-based supersaturation measurements and membrane transport rates in simulated and aspirated human fluids. Molecular Pharmaceutics. 16 (12):5042-5053. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00956 284. Voelker, A.L., Verbeek, G., Taylor, L. S. and Mauer, L. J. (2019). Effects of emulsifiers on the moisture sorption and crystallization of amorphous sucrose lyophiles. Food Chemistry. 3:100050. http://dx.doi.org/10.1016/j.fochx.2019.100050 283. Purohit, H.S., Trasi, N.S., Osterling, D.J., Stolarik, D.F., Jenkins, G.J., Gao, W., Zhang, G.G.Z., Taylor, L.S. (2019). Assessing the Impact of Endogenously Derived Crystalline Drug on the in Vivo Performance of Amorphous Formulations. Molecular Pharmaceutics. http://dx.doi.org/10.1021/acs.molpharmaceut.9b00455 282. Dening, T.J., Zemlyanov, D., Taylor, L.S. (2019). Application of an adsorption isotherm to explain incomplete drug release from ordered mesoporous silica materials under supersaturating conditions. Journal of Controlled Release. 307:186-199. http://dx.doi.org/10.1016/j.jconrel.2019.06.028 281. Dong, Y., Novo, D.C., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2019). Cellulose-Bile Ester Conjugates by Olefin Cross-metathesis: A CM Strategy for Access to Complex Polysaccharide Structures. Carbohydrate Polymers 221: 37-47. http://dx.doi.org/10.1016/j.carbpol.2019.05.061 280. Moseson, D. E., Parker, A. S., Gilpin, C. J., Stewart, A. A., Beaudoin, S. P. and Taylor, L. S. (2019). Dissolution of Indomethacin Crystals into a Polymer Melt: Role of Diffusion and Fragmentation. Crystal Growth and Design.19:3315-3328. http://dx.doi.org/10.1021/acs.cgd.9b00200 279. Li, N., and Taylor, L.S. (2019). Microstructure Formation for Improved Dissolution Performance of Lopinavir Amorphous Solid Dispersions. Molecular Pharmaceutics. http://dx.doi.org/10.1021/acs.molpharmaceut.9b00117 278. Saboo, S., Mugheirbi, N. A., Zemlyanov, D.Y., Kestur, U. S., and Taylor, L. S. (2019) Congruent release of drug and polymer: A “sweet spot” in the dissolution of amorphous solid dispersions. Journal of Controlled Release. 298:68-82. http://dx.doi.org/10.1016/j.jconrel.2019.01.039 277. Indulkar, A. S., Lou, X., Zhang, G. G. Z., and Taylor, L. S. (2019). Insights into the dissolution mechanism of ritonavir-copovidone amorphous solid dispersions: importance of congruent release for enhanced performance. Molecular Pharmaceutics. 16(3):1327-1339.http://dx.doi.org/10.1021/acs.molpharmaceut.8b01261 276. Mauer, L. J., Forny, L., Meunier, V., and Taylor, L. S. (2019). Optimizing the quality of dry ingredient blends and powder products: the challenges of moisture-mediated phase transformations. Annual Review of Food Science and Technology. 10:457-478. http://dx.doi.org/10.1146/annurev-food-032818-121224 275. Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2019). Insight into Amorphous Solid Dispersion Performance by Coupled Dissolution and Membrane Mass Transfer Measurements. Molecular Pharmaceutics. 16(1):448-461. http://dx.doi.org/10.1021/acs.molpharmaceut.8b01117 274. Wilson, V. Lou, X., Osterling, D. J., Stolarik, D. F., Jenkins, G., Gao, W., Zhang, G. G. Z., and Taylor, L. S. (2018). Relationship between amorphous solid dispersion in vivo absorption and in vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport. Journal of Controlled Release. 292:172-182.. http://dx.doi.org/10.1016/j.jconrel.2018.11.003 273. Hsu, H., Taylor, L. S., and Harris, M. T. (2018). Impact of Additives on Heterogeneous Crystallization of Acetaminophen. International Journal of Chemical Engineering. http://dx.doi.org/10.1155/2018/3604320 272. Mosquera-Giraldo, L. I., Borca, C. H., Parker, A. S., Dong, Y., Edgar, K. J., Beaudoin, S. P., Slipchenko, L.V, and Taylor, L. S. (2018). Crystallization Inhibition Properties of Cellulose Esters and Ethers for a Group of Chemically Diverse Drugs - Experimental and Computational Insight. Biomacromolecules. 19(12):4593-4606 http://dx.doi.org/10.1021/acs.biomac.8b01280 271. Moseson, D. E., Mugheirbi, N. A., Stewart, A. A., and Taylor, L. S. (2018) Nanometer-Scale Residual Crystals in a Hot Melt Extruded Amorphous Solid Dispersion: Characterization by Transmission Electron Microscopy. Crystal Growth and Design. 18(12):7633-7640. http://dx.doi.org/10.1021/acs.cgd.8b01435 270. Moseson, D. E. and Taylor, L. S. (2018). The application of temperature-composition phase diagrams for hot melt extrusion processing of amorphous solid dispersions to prevent residual crystallinity. International Journal of Pharmaceutics. 553(1-2):454-466. http://dx.doi.org/10.1016/j.ijpharm.2018.10.055 269. Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018). Assessing the risk of salt disproportionation using crystal structure and surface topography analysis. Crystal Growth and Design. 18(11):7027-7040. http://dx.doi.org/10.1021/acs.cgd.8b01188 268. Thorat, A. A., Forny, L., Meunier, V., Taylor, L. S., and Mauer, L. J. (2018). Effects of Mono-, Di-, and Tri-saccharides on the Stability and Crystallization of Amorphous Sucrose. Journal of Food Science. 83(11):2827-2839. http://dx.doi.org/10.1111/1750-3841.14357 267. Dening, T. J., and Taylor, L. S. Supersaturation Potential of Ordered Mesoporous Silica Delivery Systems. Part 1: Dissolution Performance and Drug Membrane Transport Rates. (2018) Molecular Pharmaceutics. 15(8):3489-3501. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00488 266. Voelker, A., Miller, J., Running, C.A., Taylor, L. S. and Mauer, L. J. Chemical stability and reaction kinetics of two thiamine salts (thiamine mononitrate and thiamine chloride hydrochloride) in solution. (2018). Food Research International. 112:443-456. http://dx.doi.org/10.1016/j.foodres.2018.06.056 265. Indulkar, A. S., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S.(2018). Crystallization from supersaturated solutions: Role of lecithin and composite simulated intestinal fluid. Pharmaceutical Research. 35(8):158. http://dx.doi.org/10.1007/s11095-018-2441-2 264. Mugheirbi, N. A., Mosquera-Giraldo, L. I., Borca, , Slipchenko, L.V, and Taylor, L. S. (2018). Phase Behavior of Drug-Hydroxypropyl Methylcellulose Amorphous Solid Dispersions Produced from Various Solvent Systems: Mechanistic Understanding of the Role of Polymer using Experimental and Theoretical Methods. Molecular Pharmaceutics. 15(8):3236-3251. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00324 263. Arca, H., C., Bi, V., Mosquera-Giraldo, L. I., Xu, D., Taylor, L. S., and Edgar, K. J. (2018). Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters.Biomacromolecules. 19(7):2351-2376. http://dx.doi.org/10.1021/acs.biomac.8b00517 262. Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018).Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt. International Journal of Pharmaceutics. 546 (1-2): 226-234. http://dx.doi.org/10.1016/j.ijpharm.2018.05.035 261. Bhujbal, S.V., Zemlyanov, D.Y., Cavallaro, A., Mangal, S., Taylor, L. S. and Zhou, Q. T. (2018). Qualitative and Quantitative Characterization of Composition Heterogeneity on the Surface of Spray Dried Amorphous Solid Dispersion Particles by an Advanced Surface Analysis Platform with High Surface Sensitivity and Superior Spatial Resolution. Molecular Pharmaceutics. 15(5):2045-2053. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00122 260. Li, N., and Taylor, L.S. Tailoring supersaturation from amorphous solid dispersions. (2018) Journal of Controlled Release. http://dx.doi.org/10.1016/j.jconrel.2018.04.014 259. Tres, F., Posada, M. M., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2018). Mechanistic Understanding of the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs. International Journal of Pharmaceutics. 543 (1-2):29-37. http://dx.doi.org/10.1016/j.ijpharm.2018.03.038 258. Mosquera-Giraldo, L. I., Li, N., Wilson, V. R., Nichols, B. L. B., Edgar, K. J., and Taylor, L. S. (2018). Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir. Molecular Pharmaceutics. 15(4):1700-1713. http://dx.doi.org/10.1021/acs.molpharmaceut.8b00104 257. Sugihara, H. and Taylor, L. S. (2018). Evaluation of Pazopanib Phase Behavior Following pH-Induced Supersaturation. Molecular Pharmaceutics. 15(4):1690-1699 http://dx.doi.org/10.1021/acs.molpharmaceut.8b00081 256. Liu, S., Gao, C., Mosquera-Giraldo, L. I., Taylor, L. S., and Edgar, K. J. (2018). Selective Synthesis of Curdlan Omega Carboxyamides by Staudinger Ylide Nucleophilic Ring-opening. Carbohydrate Polymers. 190:222-231. http://dx.doi.org/10.1016/j.carbpol.2018.02.074 255. Que, C., Gao, Y., Raina, S. A., Zhang, G. Z. Z., and Taylor, L. S. (2018). Paclitaxel Crystal Seeds with Different Intrinsic Properties and Their Impact on Dissolution of Paclitaxel-HPMCAS Amorphous Solid Dispersions. Crystal Growth and Design. 18(3):1548-1559. http://dx.doi.org/10.1021/acs.cgd.7b01521 254. Bhardwaj, V., Trasi, N. S., Zemlyanov, D. Y., and Taylor, L. S. (2018). Surface area normalized dissolution to study differences in itraconazole-copovidone solid dispersions prepared by spray-drying and hot melt extrusion. International Journal of Pharmaceutics. 540(1-2):106-119. http://dx.doi.org/10.1016/j.ijpharm.2018.02.005 253. Purohit, H., Trasi, N. S., Sun, D. D., Chow, E. C. Y., Wen, H., Zhang, X., Gao, Y., and Taylor, L. S.(2018). Investigating the impact of drug crystallinity in amorphous tacrolimus capsules on pharmacokinetics and bioequivalence using discriminatory in vitro dissolution testing and PBPK modeling and simulation. Journal of Pharmaceutical Sciences. 107(5):1330-1341. http://dx.doi.org/10.1016/j.xphs.2017.12.024 252. Tres, F., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2018). Monitoring the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs Using Fluorescence Techniques. Journal of Pharmaceutical Sciences. 107(1):94-102. http://dx.doi.org/10.1016/j.xphs.2017.10.002 251. Winslow, C. J., Nichols, B. L. B, Novo, D. C. , Mosquera-Giraldo, L. I. , Taylor, L. S., Edgar, K. J., and Neilson, A. P. (2018). Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro. Carbohydrate Polymers. 182(15):149-158. http://dx.doi.org/10.1016/j.carbpol.2017.11.024 250. Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018) Impact of solid-state form on the disproportionation of miconazole mesylate. Molecular Pharmaceutics. 15(1):40-52. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00694 249. Kalra, A., Luner, P., Taylor, L. S., Byrn, S. R., and Li, T. (2018). Gaining Thermodynamic Insight from Distinct Glass Formation Kinetics of Structurally Similar Organic Compounds. Journal of Pharmaceutical Sciences. 107(1):192-202. http://dx.doi.org/10.1016/j.xphs.2017.06.012 248. Elkhabaz, A., Sarkar, S., Dinh, J. K., Simpson, G. J., and Taylor, L.S. (2018) Variation in the Supersaturation and Phase Behavior of Ezetimibe Amorphous Solid Dispersions Upon Dissolution in Different Biorelevant Media. Molecular Pharmaceutics. 15(1):193-206. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00814 247. Arca, H., C., Mosquera-Giraldo, L. I., Pereira, J. M. Sriranganathan, N., Taylor, L. S., Edgar, K. J. (2018). Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices. Journal of Pharmaceutical Sciences. 107(1):127-138. http://dx.doi.org/10.1016/j.xphs.2017.05.036 246. Alin, J., Setiawan, N., Defrese, M., DiNunzio, J., Lau, H., Lupton, L., Xi, H., Su, Y., Nie, H., Hesse, N., Taylor, L. S., and Marsac, P. J. (2018) A novel approach for measuring room temperature enthalpy of mixing and associated solubility estimation of a drug in a polymer matrix. Polymer. 135(17):50-60. http://dx.doi.org/10.1016/j.polymer.2017.11.056 245. Thorat, A. A., Forny, L., Meunier, V., Taylor, L. S., and Mauer, L. J. (2017) Effects of chloride and sulfate salts on the inhibition or promotion of sucrose crystallization in initially amorphous sucrose-salt blends.. Journal of Agricultural and Food Chemistry. 65(51):11259-11272. http://dx.doi.org/10.1021/acs.jafc.7b04746 244. Tian, B., Gao, W., Tao, X., Tang, X., and Taylor, L. S. (2017) Impact of Polymers on the Melt Crystal Growth Rate of Indomethacin Polymorphs. Crystal Growth and Design. 17(12):6467-6476. http://dx.doi.org/10.1021/acs.cgd.7b01145 243. Mugheirbi, N. A., Marsac, P. J. and Taylor, L. S. (2017) Insights into Water-Induced Phase Separation in Itraconazole-hydroxypropylmethyl cellulose Spin Coated and Spray Dried Dispersions. Molecular Pharmaceutics. 14(12):4387-4402. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00499 242. Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2017) Absorptive Dissolution Testing of Supersaturating Systems: Impact of Absorptive Sink Conditions on Solution Phase Behavior and Mass Transport. Molecular Pharmaceutics. 14(11):4052-4063. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00740 241. Purohit, H. S., and Taylor, L. S. (2017). Phase Behavior of Ritonavir Amorphous Solid Dispersions During Hydration and Dissolution. Pharmaceutical Research. 34(12):2842-2861. http://dx.doi.org/10.1007/s11095-017-2265-5 240. Arca, H., C., Mosquera-Giraldo, L. I., Dahal, D., Taylor, L. S., and Edgar, K. J. (2017). Multidrug, Anti-HIV Amorphous Solid Dispersions: Nature and Mechanisms of Impacts of Drugs on Each Other’s Solution Concentrations. Molecular Pharmaceutics. 14(11):3617-3627. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00203 239. Mugheirbi, N. A., O’Connel, P., Taylor, L. S., and Tajber, L. (2017) A comparative study on the performance of inert and functionalized spheres coated with solid dispersions made of two structurally related antifungal drugs. Molecular Pharmaceutics. 14(11):3718-3728. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00482 238. Correa-Soto, C., Trasi, N. S., Schmitt, P. D. Su, Y., Liu, Z., Variankaval, N., Marsac, P. J., Simpson, G. J., and Taylor, L. S. (2017). Second Harmonic Generation Microscopy as a Tool for the Early Detection of Crystallization in Spray Dried Dispersions. Journal of Pharmaceutical and Biomedical Analysis. 146:86-95. http://dx.doi.org/10.1016/j.jpba.2017.07.066 237. Xie, T., Gao, W., and Taylor, L. S. (2017). Impact of Eudragit EPO and Hydroxypropyl Methylcellulose on Drug Release Rate, Supersaturation, Precipitation Outcome and Redissolution Rate of Indomethacin Amorphous Solid Dispersions. International Journal of Pharmaceutics. 531(1):313-323. http://dx.doi.org/10.1016/j.ijpharm.2017.08.099 236. Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Patel, S., Litster, J. D., and Taylor, L. S. (2017). Compositional Effect of Complex Biorelevant Media on the Crystallization Kinetics of an Active Pharmaceutical Ingredient. CrystEngComm. 19:4797-4806. http://dx.doi.org/10.1039/C7CE01128H 235. Saboo, S., and Taylor, L. S. (2017). Water-induced Phase Separation of Miconazole-Poly (Vinylpyrrolidone-Co-Vinyl Acetate) Amorphous Solid Dispersions: Insights with Confocal Fluorescence Microscopy. International Journal of Pharmaceutics. 529(1-2):654-666. http://dx.doi.org/10.1016/j.ijpharm.2017.07.034 234. Trasi, N. S., Purohit, H., and Taylor, L. S. (2017). Evaluation of the Crystallization Tendency of Commercially Available Amorphous Tacrolimus Formulations Exposed to Different Stress Conditions. Pharmaceutical Research. 34(10):2142-2155. http://dx.doi.org/10.1007/s11095-017-2221-4 233. Arioglu-Tuncil, S., Bhardwaj, V., Taylor, L. S. and Mauer, L. J. (2017). The Crystallization Inhibitor Properties of Different Polymers in Thiamine Chloride Hydrochloride Amorphous Solid Dispersions. Food Research International. 99(1):263-374. http://dx.doi.org/10.1016/j.foodres.2017.05.021 232. Indulkar, A. S., Waters, J. E., Mo, H., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2017). Origin of Nanodroplet Formation upon Dissolution of an Amorphous Solid Dispersion: A Mechanistic Isotope Scrambling Study. Journal of Pharmaceutical Sciences. 106(8):1998-2008. http://dx.doi.org/10.1016/j.xphs.2017.04.015 231. Kalra, A., Tishmack, P., Lubach, J. W., Munson, E., Taylor, L. S., Byrn, S. R., and Li, T. (2017). Impact of Supramolecular Aggregation on the Crystallization Kinetics of Organic Compounds from the Supercooled Liquid State. Molecular Pharmaceutics. 14(6):2126–2137. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00245 230. Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Patel, S., Litster, J. D., and Taylor, L. S. (2017). Impact of Bile Salts on Solution Crystal Growth Rate and Residual Supersaturation of an Active Pharmaceutical Ingredient. Crystal Growth and Design. 17(6):3528–3537. http://dx.doi.org/10.1021/acs.cgd.7b00464 229. Purohit, H.S., Ormes, J. D., Saboo, S., Su, Y., Lamm, M. S., Mann, A. K. P., and Taylor, L. S. (2017). Insights into Nano- and Micron-scale Phase Separation in Amorphous Solid Dispersions using Fluorescence-based Techniques in Combination with Solid State Nuclear Magnetic Resonance Spectroscopy. Pharmaceutical Research. 34(7):1364-1377. http://dx.doi.org/10.1007/s11095-017-2145-z 228. Li, N., Gilpin, C. J. and Taylor, L. S. (2017) Understanding the impact of water on the miscibility and microstructure of amorphous solid dispersions – An AFM/LCR and TEM/EDX study. Molecular Pharmaceutics. 14(5):1691–1705. http://dx.doi.org/10.1021/acs.molpharmaceut.6b01151 227. Dong, Y., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2017). Tandem Modification of Amphiphilic Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-metathesis and Thiol-Michael Addition. Polymer Chemistry. 8:3129-3139. http://dx.doi.org/10.1039/C7PY00228A 226. Icten, E., Purohit, H. S., Wallace, C., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2017). Dropwise Additive Manufacturing of Pharmaceutical Products for Amorphous and Self Emulsifying Drug Delivery Systems. International Journal of Pharmaceutics. 524(1-2):424-432. http://dx.doi.org/10.1016/j.ijpharm.2017.04.003. 225. Indulkar, A. S., Mo, H., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2017). Impact of micellar surfactant on supersaturation and insight into solubilization mechanisms in supersaturated solutions. Pharmaceutical Research. 34(6):1276-1296. http://dx.doi.org/10.1007/s11095-017-2144-0 224. Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Litster, J. D., and Taylor, L. S. (2017). Maintaining Supersaturation of Active Pharmaceutical Ingredient Solutions with Biologically Relevant Bile Salts. Crystal Growth and Design. 17(5):2782–2791. http://dx.doi.org/10.1021/acs.cgd.7b00237 223. Thorat, A., Marrs, K. N., Ghorab, M. K., Meunier, V., Forny, L., Taylor, L. S, and Mauer, L. J. (2017). Moisture-Mediated Interactions between Amorphous Maltodextrins and Crystalline Fructose. Journal of Food Science. 82(5):1142–1156. http://dx.doi.org/10.1111/1750-3841.13676 222. Lu, J., Ormes, J. D., Lowinger, M., Xu, W., Mitra, A., Mann, A. K. P., Litster, J. D., and Taylor, L. S. (2017). Impact of Endogenous Bile Salts on the Thermodynamics of Supersaturated Active Pharmaceutical Ingredient Solutions. Crystal Growth and Design. 17(3):1264-1275. http://dx.doi.org/10.1021/acs.cgd.6b01664 221. Arca, H.C., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2017). Synthesis and characterization of alkyl cellulose ω-carboxyesters for amorphous solid dispersion. 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Crystal Growth and Design. 16(12):7286-7300. http://dx.doi.org/10.1021/acs.cgd.6b01470 213. Tian, B., Tang, X., and Taylor, L. S. (2016). Investigating the Correlation between Miscibility and Physical Stability of Amorphous Solid Dispersions Using Fluorescence-based Techniques. Molecular Pharmaceutics. 13(11):3988-4000. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00803 212. Mosquera-Giraldo, L. I., Borca, C. H., Meng, X., Edgar, K. J., Slipchenko, L.V, and Taylor, L. S. (2016). Mechanistic Design of Chemically Diverse Polymers with Applications in Oral Drug Delivery. Biomacromolecules. 17(11):3659-3671. http://dx.doi.org/10.1021/acs.biomac.6b01156 211. Nie, H., Su, Y., Zhang, M., Song, Y., Leone, A., Taylor, L.S., Marsac, P. J., Li, T., and Byrn, S. R. (2016). Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions. Molecular Pharmaceutics. 13(11):3964-3975. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00740 210. Lu, M. and Taylor, L. S. (2016). Vemurafenib: A Tetramorphic System Displaying Concomitant Crystallization from the Supercooled Liquid. Crystal Growth and Design. 16(10):6033-6042. http://dx.doi.org/10.1021/acs.cgd.6b01066 209. Nie, H., Xu, W., Ren, J., Taylor, L. S., Marsac, P. J., John, C. T., and Byrn, S. R. (2016). Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. Molecular Pharmaceutics. 13(10):3541-3552. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00630 208. Dong, Y., Mosquera-Giraldo, L. I, Troutman, J., Skogstad, B., Taylor, L. S. and Edgar, K. J. (2016). Amphiphilic Hydroxyalkyl Cellulose Derivatives for Amorphous Solid Dispersion Prepared by Olefin Cross-Metathesis. Polymer Chemistry. 7:4953-4963.http://dx.doi.org/10.1039/C6PY00960C 207. Sun, D. D., Wen, H. and Taylor, L. S. (2016). 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Pharmaceutical Research. 33(7):1723-1735. http://dx.doi.org/10.1007/s11095-016-1913-5 203. Taylor, L. S. and Zhang, G. G. Z. (2016) Physical Chemistry of Supersaturated Solutions and Implications for Oral Absorption. Advanced Drug Delivery Reviews. 101:122-142. http://dx.doi.org/10.1016/j.addr.2016.03.006 202. Alhalaweh, A., Bergström, C. A. S. and Taylor, L. S. (2016). Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations. Journal of Controlled Release.229:172-182. http://dx.doi.org/10.1016/j.jconrel.2016.03.028 201. Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Characterization of Highly Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions. Pharmaceutical Research. 33(5):1276-1288. http://dx.doi.org/10.1007/s11095-016-1871-y 200. Li., N. and Taylor, L. S. (2016). 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Crystal Growth and Design. 16(2):737-748. http://dx.doi.org/10.1021/acs.cgd.5b01341 196. Dong, Y., Mosquera-Giraldo, L. I., Taylor, L. S. and Edgar, K. J. (2016). Design of Functionalized Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-Metathesis. Biomacromolecules. 17(2):454-465. http://dx.doi.org/10.1021/acs.biomac.5b01336 195. Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type. Molecular Pharmaceutics. 13(1):223-231. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00652 194. Xie, T., and Taylor, L. S. (2016). Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations. Pharmaceutical Research. 33(3):739-750. http://dx.doi.org/10.1007/s11095-015-1823-y 193. Nie, H., Liu, Z., Marks, B. C., Taylor, L. S., Byrn, S. R. and Marsac, P. J. (2016). 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Pharmaceutical Research. 32(11):3660-3673. http://dx.doi.org/10.1007/s11095-015-1725-z 185. Schmitt, P. D., Trasi, N. S., Taylor, L. S. and Simpson, G. J. Finding the Needle in the Haystack – Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. (2015) Molecular Pharmaceutics. 12(7):2378-2383. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00065 184. Sato, T. and Taylor, L. S. (2015). Chiral Discrimination by a Cellulose Polymer: Differential Crystallization Inhibition of Enantiomers in Amorphous Dispersions. CrystEngComm. 17:5046-5053. http://dx.doi.org/10.1039/C5CE00810G 183. Trasi, N. S. and Taylor, L. S. (2015). Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs – Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products. Journal of Pharmaceutical Sciences. 104(8):2583-2593. http://dx.doi.org/10.1002/jps.24528 182. Raina, S. A., Zhang, G. G. Z., Alonzo, D. E., Wu, J., Zhu, D., Catron, N. D., Gao, Y. and Taylor, L. S. (2015). Impact of Solubilizing Additives on Supersaturation and Membrane Transport of Drugs. Pharmaceutical Research. 32(10):3350-3364. http://dx.doi.org/10.1007/s11095-015-1712-4 181. Christina, B., Taylor, L. S., and Mauer, L. J. (2015). Physical stability of L-ascorbic acid amorphous solid dispersions in different polymers: a study of polymer crystallization inhibitor properties. Food Research International. 76(3):867-877. http://dx.doi.org/10.1016/j.foodres.2015.08.009 180. Nie, H., Mo, H., Zhang, M., Song, Y., Fang, K., Taylor, L. S. Li, T. and. Byrn, S. R. (2015). Investigating the interaction pattern and structural elements of a drug-polymer complex at the molecular level. Molecular Pharmaceutics. 12(7)2459-2468. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00162 179. 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S. and Mauer, L. J. (2014) Water-Solid Interactions between Amorphous Maltodextrin and Crystalline Sodium Chloride. Food Chemistry. 144:26-35. http://dx.doi.org/10.1016/j.foodchem.2013.02.123 146. Ghorab, M.K, Toth, S J., Simpson, G. J., Mauer, L. J. and Taylor, L. S. (2014) Water-Solid Interactions in Amorphous Maltodextrin-Crystalline Sucrose Binary Mixtures. Pharmaceutical Development and Technology. 19(2):247-256. http://dx.doi.org/10.3109/10837450.2013.775157 145. Harrison A. J., Bilgili, E. A., Beaudoin, S. P. and Taylor, L. S. (2013) Atomic force microscope infrared spectroscopy of griseofulvin nanocrystals. Analytical Chemistry. 85(23):11449-11455. http://dx.doi.org/10.1021/ac4025889 144. Pereira, J. M., Mejia-Ariza, R., Ilevbare, G. A. McGettigan, H. E., Sriranganathan, N., Taylor, L. S., Davis, R. M. and Edgar, K. J. (2013) Interplay of Degradation, Dissolution and Stabilization of Clarithromycin and its Amorphous Solid Dispersions. Molecular Pharmaceutics. 10(12):4640-4653. http://dx.doi.org/10.1021/mp400441d 143. Kestur, U. S. and Taylor, L. S. (2013). Evaluation of the Crystal Growth Rate of Felodipine Polymorphs in the Presence and Absence of Additives as a Function of Temperature. Crystal Growth and Design. 13(10):4349-4354 http://dx.doi.org/10.1021/cg400708p 142. Ilevbare, G. A., Liu, H., Pereira, J., Edgar, K. J., Taylor, L.S. (2013). Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir. Molecular Pharmaceutics. 10(9):3392-3403. http://dx.doi.org/10.1021/mp400228x 141. Lipasek, R.A., Li, N., Schmidt, S. J. Taylor, L. S. and Mauer, L. J. (2013). Effect of Temperature on the Deliquescence Properties of Food Ingredients and Blends. Journal of Agriculture and Food Chemistry. 61(38):9241-2950. http://dx.doi.org/10.1021/jf402585t 140. Ilevbare, G. A. Liu, H, Edgar, K. J., Taylor, L.S. (2013). Impact of Polymers on the Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution. Molecular Pharmaceutics. 10(6):2381–2393. http://dx.doi.org/10.1021/mp400029v 139. Ilevbare, G. A. and Taylor, L. S. (2013). Liquid-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly-Water Soluble Drugs – Implications for Solubility Enhancing Formulations. Crystal Growth and Design. 13(4):1497-1509. http://dx.doi.org/10.1021/cg301679h 138. Li, B., Konecke, S., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013) Both Solubility and Chemical Stability of Curcumin are Enhanced by Solid Dispersion in Cellulose Derivative Matrices. Cellulose. 98: 1108-1116. http://dx.doi.org/10.1016/j.carbpol.2013.07.017 137. Li, B., Liu, H., Amin, M., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013).Enhancement of Naringenin Solution Concentration by Solid Dispersion in Cellulose Derivative Matrices. Cellulose. 20(4): 2137-2149. http://dx.doi.org/10.1007/s10570-013-9970-y 136. Li, B., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Stability and Solubility Enhancement of Resveratrol in Spray Dried Solid Dispersion with Cellulose Derivative Matrices. Cellulose. 20(3):1249-1260. http://dx.doi.org/10.1007/s10570-013-9889-3 135. Maltaş, D. C., Kwok, K., Wang, P., Taylor, L. S. and Ben-Amotz, D. (2013) Rapid Classification of Pharmaceutical Ingredients with Raman Spectroscopy Using Compressive Detection Strategy with PLS-DA Multivariate Filters. Journal of Pharmaceutical and Biomedical Analysis.80:63-68. http://dx.doi.org/10.1016/j.jpba.2013.02.029 134. Zhou, Q., Toth, S J., Simpson, G. J., Hsu H-Y., Taylor L. S., Harris, M. T., (2013) Crystallization and Dissolution Behavior of Naproxen/Polyethylene Glycol Solid Dispersions. Journal of Physical Chemistry. 117(5):1494-1500. http://dx.doi.org/10.1021/jp3106716 133. Ilevbare, G. A., Liu, H, Edgar, K. J., Taylor, L.S. (2013). Maintaining Supersaturation in Aqueous Drug Solutions - Impact of Different Polymers on Induction Times. Crystal Growth and Design. 13(2):740-751. http://dx.doi.org/10.1021/cg301447d 132. Kestur, U. S., Ivanisevic, I, Alonzo, D. E. and Taylor, L. S. (2013). Influence of Particle Size on the Crystallization Kinetics of Amorphous Felodipine Powders. Powder Technology.236:197–204. http://dx.doi.org/10.1016/j.powtec.2012.02.010 131. Li, N., Taylor, L. S. Ferruzzi, M. G. and Mauer, L. J. (2013). Color and Chemical Stability of Tea Polyphenol (-)-Epigallocatechin-3-gallate in Solution and Solid States. Food Research International. http://dx.doi.org/10.1016/j.foodres.2012.11.019 130. Li, B., Konecke, S., Harich, K., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013). Solid Dispersion of Quercetin in Cellulose Derivative or PVP Matrix Influences both Solubility and Stability. Carbohydrate Polymers. 92(2):2033-2040. http://dx.doi.org/10.1016/j.carbpol.2012.11.073 129. Hsu, H-Y, Toth, S. J., Simpson, G. J., Taylor, L. S., Harris, M. T. (2013) Effect of Substrates on Naproxen\Polyvinylpyrrolidone Solid Dispersions Formed via the Drop Printing Technique. Journal of Pharmaceutical Sciences. 102(2):638-648. http://dx.doi.org/10.1002/jps.23397 128. Abbou Oucherif, K. Raina, S., Taylor, L. S. and Litster, J. (2013) Quantitative Analysis of the Inhibitory Effect of HPMC on Felodipine Crystallization Kinetics Using Population Balance Modeling. CrystEngComm. 15:2197-2205. http://dx.doi.org/10.1039/c2ce26490k 127. Christensen, N. P. A., Van Eerdenbrugh, B., Kwok, K., Taylor, L. S., Bond, A. D. Rades, T., Rantanen, J., Cornett, C. (2013) Rapid Insight into Heating-induced Phase Transformations in the Solid-state of the Calcium Salt of Atorvastatin using Multivariate Data Analysis.Pharmaceutical Research. 30(3):826-835. http://dx.doi.org/10.1007/s11095-012-0923-1 126. Li, B., Harich, K., Wegiel, L.A., Taylor, L.S. and Edgar, K.J. (2013) Stability and Solubility Enhancement of Ellagic Acid in Cellulose Ester Solid Dispersions. Carbohydrate Polymers.92:1443-1450. http://dx.doi.org/10.1016/j.carbpol.2012.10.051 125. Baird, J.A., Thomas, L.C., Aubuchon, S.R. and Taylor, L. S. (2013). Evaluating the Non-isothermal Crystallization Behavior of Organic Molecules from the Undercooled Melt State using Rapid Heat/Cool Calorimetry. CrystEngComm. 15(1):111-119. http://dx.doi.org/10.1039/C2CE26448J 124. Wegiel, L.A., Mauer, L.J. , Edgar, K.J., and Taylor, L.S.(2013) Crystallization of Amorphous Solid Dispersions of Resveratrol during Preparation and Storage – Impact of Different Polymers. Journal of Pharmaceutical Sciences. 102(1):171-184. http://dx.doi.org/10.1002/jps.23358 123. Back, K. R., Davey, R.J., Grecu, T., Hunter, C. A. and Taylor, L. S. (2012) Molecular Conformation and Crystallisation – The Case of Ethenzamide. Crystal Growth and Design. 12(12):6110-6117. http://dx.doi.org/10.1021/cg301244x 122. Ilevbare, G. A., Liu, H., Edgar, K. J., Taylor, L.S. (2012). The Effect of Binary Additive Combinations on Solution Crystal Growth of the Poorly Water-Soluble Drug, Ritonavir. Crystal Growth and Design.12(12):6050-6060. http://dx.doi.org/10.1021/cg301169t 121. Stoklosa, A. M., Lipasek, R. Taylor, L. S. and Mauer, L. J. (2012) Effects of Storage Conditions, Formulation, and Particle Size on Moisture Sorption and Flowability of Powders: a Study of Deliquescent Ingredient Blends. Food Research International. 49: 783-791. http://dx.doi.org/10.1016/j.foodres.2012.09.034 120. Kestur, U. S., Wanapun, D., Toth, S.J. , Wegiel, L. A., Simpson, G. J. and Taylor, L. S. (2012) Nonlinear Optical Imaging for Sensitive Detection of Crystals in Bulk Amorphous Powders. Journal of Pharmaceutical Sciences. 101(11):4201–4213. http://dx.doi.org/10.1002/jps.23280 119. Ilevbare, G. A. Liu, H, Edgar, K. J., Taylor, L.S. (2012). Inhibition of Solution Crystal Growth of Ritonavir by Cellulose Polymers – Factors Influencing Polymer Effectiveness. CrystEngComm. 14:6503-651. http://dx.doi.org/10.1039/C2CE25515D 118. Christensen, N. P. A., Rantanen, J., Cornett, C., and Taylor, L. S. (2012) Physical Stability of the Calcium Salt of Atorvastatin in the Presence of Acidic Excipients. European Journal of Pharmaceutics and Biopharmaceutics. 82:410-416. http://dx.doi.org/10.1016/j.ejpb.2012.07.003 117. Toth, S.J., Madden, J. T., and Taylor, L. S., Marsac, P.J., and Simpson, G. J. (2012) Selective Imaging of Active Pharmaceutical Ingredients in Powdered Blends with Common Excipients Utilizing Two-Photon Excited Ultraviolet-Fluorescence and Ultraviolet-Second Order Nonlinear Optical Imaging of Chiral Crystals. Analytical Chemistry. 84(14):5859-5875. http://dx.doi.org/10.1021/ac300917t 116. Trasi, N. S. and Taylor, L. S. (2012). Effect of Polymers on Nucleation and Crystal Growth of Amorphous Acetaminophen. CrystEngComm. 14(16):5188-5197. http://dx.doi.org/10.1039/C2CE25374G 115. Hsieh, Y-L., Ilevbare, G.A., Van Eerdenbrugh, B., Box, K., Sanchez-Felix, M. V. and Taylor, L. S. (2012) pH-Induced Precipitation Behavior of Weakly Basic Compounds – Determination of Extent and Duration of Supersaturation using Potentiometric Titration and Correlation to Solid State Properties. Pharmaceutical Research. 29(10):2738-2753. http://dx.doi.org/10.1007/s11095-012-0759-8 114. Trasi, N. S., and Taylor, L. S. (2012). Effect of Additives on Crystal Growth and Nucleation of Amorphous Flutamide. Crystal Growth and Design.12(6):3221-3230. http://dx.doi.org/10.1021/cg300370q 113. Ilevbare, G. A., Liu, H., Edgar, K. J., Taylor, L.S. (2012) Understanding Polymer Properties Important for Crystal Growth Inhibition – Impact of Chemically Diverse Polymers on Solution Crystal Growth of Ritonavir. Crystal Growth and Design. 12(6):3133-3143. http://dx.doi.org/10.1021/cg300325p 112. Van Eerdenbrugh, B., Lo, M., Kjoller, K., Marcott, C. and Taylor, L.S. (2012) Nanoscale Mid-Infrared Evaluation of the Miscibility Behavior of Blends of Dextran or Maltodextrin with Poly(vinylpyrrolidone). Molecular Pharmaceutics. 9(5):1459-1469. http://dx.doi.org/10.1021/mp300059z 111. Kwok, K. and Taylor, L. S. (2012). Analysis of Counterfeit Cialis® Tablets Using Raman Microscopy and Multivariate Curve Resolution. Journal of Pharmaceutical and Biomedical Analysis.66:126-135. http://dx.doi.org/10.1016/j.jpba.2012.03.026 110. Kwok, K. and Taylor, L. S. (2012). Analysis of the Packaging Enclosing a Counterfeit Pharmaceutical Tablet using Raman Microscopy and Two-dimensional Correlation Spectroscopy. Vibrational Spectroscopy. 161:176-182. http://dx.doi.org/10.1016/j.vibspec.2012.02.018 109. Van Eerdenbrugh, B., Lo, M., Kjoller, K., Marcott, C. and Taylor, L.S. (2012) Nanoscale Mid-Infrared Imaging of Phase Separation in a Drug-Polymer Blend. Journal of Pharmaceutical Sciences. 101(6):2066-2073. http://dx.doi.org/10.1002/jps.23099 108. Li, N., Taylor, L. S. Ferruzzi, M. G. and Mauer, L. J. (2012) Kinetic study of catechin stability: Effects of pH,concentration, and temperature. Journal of Agricultural and Food Chemistry. 60(51)12531-12539. http://dx.doi.org/10.1021/jf304116s 107. Zhou, Q. Harris, M. T., and Taylor L. S. (2012) Modification of Crystallization Behavior in Drug/Polyethylene Glycol Solid Dispersions. Molecular Pharmaceutics. 9(3):546-553. http://dx.doi.org/10.1021/mp200546p 106. Alonzo, D.E., Raina, S., Zhou, D.,Gao, Y., Zhang, G.G.Z., and Taylor, L.S. (2012). Characterizing the Impact of Hydroxypropylmethyl Cellulose on the Growth and Nucleation Kinetics of Felodipine from Supersaturated Solutions. Crystal Growth and Design. 12(3):1538-1547. http://dx.doi.org/10.1021/cg201590j. 105. Van Eerdenbrugh, B. and Taylor, L. S. (2012) . 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Role of Viscosity in Influencing the Glass-forming Ability of Organic Molecules from the Undercooled Melt State. Pharm. Res. 29(1):271-284. http://dx.doi.org/10.1007/s11095-011-0540-4 100. Lipasek, R. A., Ortiz, J. C., Taylor, L. S. and Mauer, L. J. (2012) Effects of Anticaking Agents and Storage Conditions on the Moisture Sorption, Caking, and Flowability of Deliquescent Ingredients. Food Research International. 45(1):369-380. http://dx.doi.org/10.1016/j.foodres.2011.10.037 99. Rumondor, A.C.F, Wikström, H., Van Eerdenbrugh, B. and Taylor, L. S. (2011). Understanding the Tendency of Amorphous Solid Dispersions to Undergo Amorphous–Amorphous Phase Separation in the Presence of Absorbed Moisture. AAPSPharmSciTech. 12(4):1209-1219. http://dx.doi.org/10.1208/s12249-011-9686-y 98. Kestur, U.S., Van Eerdenbrugh, B. and Taylor, L.S. (2011) Influence of polymer chemistry on crystal growth inhibition of two chemically diverse organic molecules. CrystEngComm. 13:6712-6718 http://dx.doi.org/10.1039/c1ce05822c 97. Van Eerdenbrugh, B., and Taylor L. S. (2011). An Ab Initio Polymer Selection Methodology to Prevent Crystallization in Amorphous Solid Dispersions by Application of Crystal Engineering Principles. CrystEngComm. 13:6171-6178. http://dx.doi.org/10.1039/c1ce05183k 96. Lipasek, R. A., Taylor, L.S., and Mauer, L. J. (2011) Effects of Anticaking Agents and Relative Humidity on the Physical and Chemical Stability of Powdered Vitamin C. Journal of Food Science. 176(7):C1062-C1074 http://dx.doi.org/10.1111/j.1750-3841.2011.02333.x 95. Alonzo, D.E., Gao, Y.,Zhou, D., Mo, H., Zhang, G.G.Z., and Taylor, L.S. (2011) Dissolution and Precipitation Behavior of Amorphous Solid Dispersions. J. Pharm. Sci. 100(8):3316-3331. http://dx.doi.org/10.1002/jps.22579 94. Wanapun, D., Kestur, U. S., Kissick, D. J., Taylor, L. S., and Simpson, G. J. (2011) Single particle nonlinear optical imaging of trace crystallinity in an organic powder. Anal. Chem. 83(12):4745-4751. http://dx.doi.org/10.1021/ac1031397 93. Zhou, Q. Harris, M. T., and Taylor L. S. (2011) Time-resolved SAXS/WAXS study of the phase behavior and microstructural evolution of drug/PEG solid dispersions. Mol. Pharm. 8(3):932-939. http://dx.doi.org/10.1021/mp200041j 92. Baird, J. A. and Taylor, L. S. (2011) Evaluation and Modeling of the Eutectic Composition of Various Drug-Polyethylene Glycol Solid Dispersions. Pharmaceutical Development and Technology. 16(3):201-211 http://dx.doi.org/10.3109/10837450903584936 91. Van Eerdenbrugh, B., Alonzo, D. E. and Taylor L. S. (2011). Influence of particle size on the ultraviolet spectrum of particulate-containing solutions – implications for in-situ concentration monitoring using UV/Vis fiber-optic probes. Pharm. Res. 28(7):1643-1652. http://dx.doi.org/10.1007/s11095-011-0399-4 90. Sung,P-F., Hsieh Y-L., Angonese, K. Dunn, D., King, K., Machbitz, R., Christianson, A. Taylor, L. S., Harris, M. T., (2011) Complex Dielectric Properties of Microcrystalline Cellulose (MCC), Anhydrous Lactose and α-Lactose Monohydrate Powders Using a Microwave-Based Open Reflection Resonator Sensor. J. Pharm. Sci. 100(7):2920-2934 http://dx.doi.org/10.1002/jps.22516 89. Li, N., Taylor, L.S., and Mauer, L.J. (2011) Degradation kinetics of catechins in green tea powder: Effects of temperature and relative humidity. J. Agric. Food Chem. 59(11):6082-6090. http://dx.doi.org/10.1021/jf200203n 88. Van Eerdenbrugh, B., and Taylor L. S. (2011). Application of Mid-IR Spectroscopy for the Characterization of Pharmaceutical Systems. International Journal of Pharmaceutics. 417:3-16. http://dx.doi.org/10.1016/j.ijpharm.2010.12.011 87. Hiatt, A. N., Taylor, L. S. and Mauer, L. J. (2011). Effects of co-formulation of amorphous maltodextrin and deliquescent sodium ascorbate on moisture sorption and stability. International Journal of Food Properties. 14(4):726-740. http://dx.doi.org/10.1080/10942910903374114 . 86. Guerrieri, P., Zemlyanov, D., and Taylor, L.S. (2011) A study of water adsorption on organic crystal surfaces using a modified X-ray photoelectron spectroscopy instrument. Anal. Chem. 83(3):1144-1147. http://dx.doi.org/10.1021/ac102550e 85. Van Eerdenbrugh, B., Fanwick, P. E. and Taylor L. S. (2010).2-Butoxy-N-[2-(diethylamino)ethyl]-quinoline-4-carboxamide (dibucaine). Acta Crystallographica E. E66 o3189. http://dx.doi.org/10.1107/S1600536810045460 84. Kwok, K., Mauer, L. J. and Taylor, L.S. (2010) Kinetics of moisture-induced hydrolysis in powder blends stored at and below the deliquescence relative humidity: investigation of sucrose-citric acid mixtures. Journal of Agricultural and Food Chemistry. 58(22):11716-11724. http://dx.doi.org/10.1021/jf101941e 83. Van Eerdenbrugh, B., Fanwick, P. E. and Taylor L. S. (2010). 1-[(Biphenyl-4-yl)(phenyl)methyl]-1H-imidazole (bifonazole). Acta Crystallographica Section E. E66 o2649. http://dx.doi.org/10.1107/S1600536810037876 82. Van Eerdenbrugh, B., Fanwick, P. E. and Taylor L. S. (2010). 2-(Biphenyl-4-yl)acetic acid (felbinac). Acta Crystallographica E. E66 o2609. http://dx.doi.org/10.1107/S1600536810035828 81. Rumondor, A.C.F. and Taylor, L.S. (2010) Application of Partial Least Squares (PLS) Modeling in Quantifying Drug Crystallinity in Amorphous Solid Dispersions. International Journal of Pharmaceutics.398(1-2):155-160. http://dx.doi.org/10.1016/j.ijpharm.2010.07.049 80. Guerrieri, P., Rumondor, A.C.F., Li, T, and Taylor, L.S. (2010). Analysis of relationships between solid-state properties, counterion and developability of pharmaceutical salts. AAPS PharmSciTech. 11(3) 1212-1222. http://dx.doi.org/10.1208/s12249-010-9499-4 79. Zhou, Q., Taylor L. S. and Harris, M. T. (2010) Evaluation of the Microstructure of Semicrystalline Solid Dispersions. Molecular Pharmaceutics. 7(4):1291-1337. http://dx.doi.org/10.1021/mp1000907 78. Van Eerdenbrugh, B., and Taylor L. S. (2010). Small Scale Screening to determine the Ability of Different Polymers to Inhibit Drug Crystallization upon Rapid Solvent Evaporation. Molecular Pharmaceutics. 7(4):1328-1337. http://dx.doi.org/10.1021/mp1001153 77. Kestur, U. S., Lee, H., Santiago, D., Rinaldi, C., Won, Y-Y. and Taylor, L. S. (2010) Effects of the Molecular Weight and Concentration of Polymer Additives, and Temperature on the Melt Crystallization Kinetics of a Small Drug Molecule. Crystal Growth and Design. 10(8):3585-3596. http://dx.doi.org/10.1021/cg1004853 76. Kwok, K., Mauer, L. J. and Taylor, L.S. (2010) Phase Behavior and Moisture Sorption Behavior of Deliquescent Powders. Chemical Engineering Science. 65:5639-5650 http://dx.doi.org/10.1016/j.ces.2010.06.012. 75. Guerrieri, P., Zemlyanov, D., and Taylor, L.S. (2010) Dissociation of Water on the Surface of Organic Salts studied by X-ray Photoelectron Spectroscopy. Langmuir. 26(14): 11998-12002 http://dx.doi.org/10.1021/la101501p 74. Wanapun, D., Kestur, U. S., Kissick, D. J.,Simpson, G. J., and Taylor, L. S. (2010) Selective Detection and Quantitation of Organic Molecule Crystallization by Second Harmonic Generation Microscopy. Analytical Chemistry. 82(13): 5425-5432. http://dx.doi.org/10.1021/ac100564f 73. Van Eerdenbrugh, B., Baird, J. A. and Taylor, L. S. (2010). Crystallization tendency of active pharmaceutical ingredients following rapid solvent evaporation – classification and comparison with crystallization tendency from undercooled melts. Journal of Pharmaceutical Sciences. 99(9):3826-3838. http://dx.doi.org/10.1002/jps.22214 72. Baird, J. A., Van Eerdenbrugh, B and Taylor, L. S. (2010). A Classification System to Assess the Crystallization Tendency of Organic Molecules from Undercooled Melts. Journal of Pharmaceutical Sciences. 99(9):3787-3806. http://dx.doi.org/10.1002/jps.22197 71. Kestur, U.S. and Taylor, L.S. (2010). Role of Polymer Chemistry in Influencing Crystal Growth Rates from Amorphous Felodipine. CrystEngComm. 12:2390-2397. http://dx.doi.org/10.1039/c001905d 70. Hiatt, A. N., Ferruzzi, M. G., Taylor, L. S. and Mauer, L. J. (2011) Deliquescence behavior and chemical stability of vitamin C forms (ascorbic acid, sodium ascorbate, and calcium ascorbate) and blends. International Journal of Food Properties. 14(6):1330-1348 http://dx.doi.org/10.1080/10942911003650338 69. Hiatt, A. N., Taylor, L. S. and Mauer, L. J. (2010) Influence of simultaneous variations in temperature and relative humidity on chemical degradation of two vitamin C forms and implications for shelf-life models. Journal of Agricultural and Food Chemistry 58(6):3532-3540. http://dx.doi.org/10.1021/jf903342f 68. Rumondor, A.C.F. and Taylor, L.S. (2010) Effect of Polymer Hygroscopicity on the Phase Behavior of Amorphous Solid Dispersions in the Presence of Moisture. Molecular Pharmaceutics. 7(2):477-490. http://dx.doi.org/10.1021/mp9002283 67. Alonzo, D.E., Zhang, G.G.Z., Zhou, D., Gao, Y., and Taylor, L.S. Understanding the Behaviour of Amorphous Pharmaceutical Systems During Dissolution. Pharmaceutical Research 27(4):608-618. http://dx.doi.org/10.1007/s11095-009-0021-1 66. Rumondor, A.C.F., Konno, H., Marsac, P.J., and Taylor, L. S. (2010) Analysis of the Moisture Sorption Behavior of Amorphous Drug-Polymer Blends. Journal of Applied Polymer Science 117(2):1055-1063. http://dx.doi.org/10.1002/app.31803 . 65. Mauer L. J. and Taylor, L. S. (2010). Water-Solids Interactions: Deliquescence. Annual Review of Food Science and Technology. 1:41-63. http://dx.doi.org/10.1146/annurev.food.080708.100915 64. Guerrieri, P., Jarring, K., and Taylor, L.S. (2010) Impact of Counterion on the Chemical Stability of Crystalline Salts of Procaine. J. Pharm. Sci. 99(9):3719-3730. http://dx.doi.org/10.1002/jps.22009 63. Rumondor, A.C.F., Jackson, M.J. and Taylor, L.S. (2010) Effects of Moisture on the Growth Rate of Felodipine Crystals in the Presence and Absence of Polymers. Crystal Growth and Design. 10(2):747-753. http://dx.doi.org/10.1021/cg901157w 62. Mauer L. J. and Taylor, L. S. (2010). Deliquescence of Pharmaceutical Systems. Pharmaceutical Development and Technology. 15(6):582-594. http://dx.doi.org/10.3109/10837450903397594 61. Marsac, P.J., Rumondor, A.C.F., Nivens, D. E., Kestur, U. S.; Stanciu, L. and Taylor, L. S. (2010) Effect of Temperature and Moisture on the Miscibility of Amorphous Dispersions of Felodipine and Poly(vinyl pyrrolidone). Journal of Pharmaceutical Sciences. 99(1):169-185 http://dx.doi.org/10.1002/jps.21809. 60. Baird, J., Olayo-Valles, R., Rinaldi, C. and Taylor, L. S. (2010) Effect of Molecular Weight, Temperature, and Additives on the Moisture Sorption Properties of Polyethylene Glycol.Journal of Pharmaceutical Sciences. 99(1):154-168 http://dx.doi.org/10.1002/jps.21808. 59. Rumondor, A.C.F., Stanford, L. A. and Taylor, L.S. (2009) Effect of Polymer Type and Storage Relative Humidity on the Kinetics of Felodipine Crystallization from Amorphous Solid Dispersions. Pharm. Res. 26 (12):2599-2606. http://dx.doi.org/10.1007/s11095-009-9974-3 58. Rumondor, A.C.F., Ivanisevic, I., Bates, S., Alonzo, D. E. and Taylor, L. S. (2009) Evaluation of Drug-Polymer Miscibility in Amorphous Solid Dispersion Systems. Pharm. Res. 26 (11):2523-2534. http://dx.doi.org/10.1007/s11095-009-9970-7 57. Rumondor, A.C.F., Marsac, P.J., Stanford, L. A., and Taylor, L. S. (2009) Phase Behavior of Poly(vinylpyrrolidone) Containing Amorphous Solid Dispersions in the Presence of Moisture. Molecular Pharmaceutics. 6 (5):1492-1505. http://dx.doi.org/10.1021/mp900050c 56. Guerrieri, P., and Taylor, L.S. (2009) Role of salt and excipient properties on disproportionation in the solid-state. Pharmaceutical Research 26(8):2015-2026. http://dx.doi.org/10.1007/s11095-009-9918-y 55. Ortiz, J., Kestur U., Taylor, L.S. and Mauer, L.J. (2009) Interaction of environmental moisture with powdered green tea formulations: Relationship between catechin stability and moisture-induced phase transformations. Journal of Agricultural and Food Chemistry. 57(11):4691-4697.http://dx.doi.org/10.1021/jf8038583 54. Gift, A.D., Luner, P.E., Luedeman, L., and Taylor, L.S. (2009). Manipulating hydrate formation during high shear wet granulation using polymeric excipients. Journal of Pharmaceutical Sciences. 98(12):4670-4683. http://dx.doi.org/10.1002/jps.21763 53. Wikström, H., Kakidas, C. and Taylor, L.S. (2009). Determination of hydrate transition temperature using transformation kinetics obtained using Raman spectroscopy. Journal of Pharmaceutical and Biomedical Analysis. 49:247-252. http://dx.doi.org/10.1016/j.jpba.2008.11.008 52. Marsac, P.J., Li, T., and Taylor, L. S. (2009) Estimation of Drug-Polymer Miscibility and Solubility in Amorphous Solid Dispersions using Experimentally Determined Interaction Parameters. Pharmaceutical Research. 26(1):139-151. http://dx.doi.org/10.1007/s11095-008-9721-1 51. Konno, H., Handa, T., Alonzo, D. E. and Taylor, L. S. (2008). Effect of Polymer Type on the Dissolution Profile of Amorphous Solid Dispersions Containing Felodipine. European Journal of Pharmaceutics and Biopharmaceutics. 70:493-499. http://dx.doi.org/10.1016/j.ejpb.2008.05.023 50. Hiatt, A.N. Ferruzzi, M., Taylor, L.S., and Mauer, L. J. (2008) Impact of deliquescence on the chemical stability of vitamins B1, B6, and C in powder blends. Journal of Agricultural and Food Chemistry. 56 (15): 6471–6479. http://dx.doi.org/10.1021/jf800709f 49. Towler C. S., Li, T. Wikström, H, Remmick, D., Sanchez-Felix M. V. and Taylor, L. S. (2008) An investigation into the influence of counter-ion on the properties of some amorphous organic salts. Molecular Pharmaceutics. 5 (6): 946-955. http://dx.doi.org/10.1021/mp8000342 48. Wikström, H.; Rantanen, J.; Gift, A. D. and Taylor, L. S. (2008) Towards an understanding of the factors influencing anhydrate-to-hydrate transformation kinetics in aqueous environments. Crystal Growth and Design. 8 (8): 2684–2693. http://dx.doi.org/10.1021/cg070629e 47. Ortiz, J., Ferruzzi, M., Taylor, L.S. and Mauer, L.J. (2008) Interaction of Environmental Moisture with Powdered Green Tea Formulations: Effect on Catechin Chemical Stability. Journal of Agricultural and Food Chemistry 56:4068-4077. http://dx.doi.org/10.1021/jf800246s 46. Gift, A.D., Luner, P.E., Luedeman, L., and Taylor, L.S. (2008) Influence of Polymeric Excipients on Crystal Hydrate Formation Kinetics in Aqueous Slurries. Journal of Pharmaceutical Sciences 97:5198-5211. http://dx.doi.org/10.1002/jps.21379 45. Marsac, P.J., Romary, D.P., Shamblin, S.L., Baird, J.A., and Taylor, L.S. (2008) Spontaneous Crystallinity Loss of Drugs in the Disordered Regions of Poly(ethylene oxide) in the Presence of Water. Journal of Pharmaceutical Sciences. 97: 3182-3194. http://dx.doi.org/10.1002/jps.21237 44. Guerrieri, P., Smith, D.T., and Taylor, L.S. (2008) Phase Behavior of Ranitidine HCl in the Presence of Atmospheric Moisture and Degradants – Influence on Chemical Reactivity. Langmuir 24:3850-3856. http://dx.doi.org/10.1021/la703031c 43. Wikström, H., Carroll, W.J., and Taylor, L.S. (2008) Manipulating theophylline hydrate formation during high shear wet granulation through improved understanding of the role of pharmaceutical excipients. Pharmaceutical Research.25(4):923-978. http://dx.doi.org/10.1007/s11095-007-9450-x 42. Konno, H., and Taylor, L.S. (2008) Ability of Different Polymers to Inhibit the Crystallization of Amorphous Felodipine in the Presence of Moisture. Pharmaceutical Research 25(4): 969-978. http://dx.doi.org/10.1007/s11095-007-9331-3 41. Marsac, P.J., Konno, H., Rumondor, A.C.F., and Taylor, L.S. (2008) Recrystallization of Nifedipine and Felodipine from Amorphous Molecular Level Solid Dispersions Containing Poly(vinylpyrrolidone) and Sorbed Water. Pharmaceutical Research 25 (3):647-656. http://dx.doi.org/10.1007/s11095-007-9420-3 40. Hu, Y., Wikström, H., Byrn, S.R., and Taylor, L.S. (2007) Estimation of the Transition Temperature for an Enantiotropic Polymorphic System from the Transformation Kinetics Monitored using Raman Spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 45:546–551. http://dx.doi.org/10.1016/j.jpba.2007.07.028 39. Romero-Torres, S., Wikström, H., Grant, E.R., and Taylor L.S. (2007) Monitoring of Mannitol Phase Behavior during Freeze-Drying Using Non-Invasive Raman Spectroscopy. PDA Journal of Pharmaceutical Science and Technology 61(2):131-145. 38. Towler, C.S., and Taylor, L.S. (2007) Spectroscopic Characterization of Inter-Molecular Interactions in Solution and Their Influence on Crystallization Outcome. Crystal Growth and Design 7(4):633-638. http://dx.doi.org/10.1021/cg0602358 37. Gift, A.D., and Taylor, L.S. (2007) Hyphenation of Raman Spectroscopy with Gravimetric Analysis to Interrogate Water-Solid Interactions in Pharmaceutical Systems. Journal of Pharmaceutical and Biomedical Analysis 43:14-23. http://dx.doi.org/10.1016/j.jpba.2006.06.025 36. Guerrieri P., Salameh A.K., and Taylor, L.S. (2007) Effect of Small Levels of Impurities on the Moisture Sorption Behavior of Ranitidine HCl. Pharmaceutical Research 24(1):147-156. http://dx.doi.org/10.1007/s11095-006-9134-y 35. Salameh, A.K., and Taylor, L.S. (2006) Deliquescence Induced Caking in Binary Powder Blends. Pharmaceutical Development and Technology 11:453-464. http://dx.doi.org/10.1080/10837450600939057 34. Konno, H., and Taylor, L.S. (2006) Influence of Different Polymers on the Crystallization Tendency of Molecularly Dispersed Amorphous Felodipine. Journal of Pharmaceutical Sciences 95(12):2692-2705. http://dx.doi.org/10.1002/jps.20697 33. Marsac, P.J., Shamblin, S.L., and Taylor, L.S. (2006) Theoretical and Practical Approaches for Prediction of Drug-Polymer Miscibility and Solubility. Pharmaceutical Research 23(10):2417-2425. http://dx.doi.org/10.1007/s11095-006-9063-9 32. Marsac, P.J., Konno, H., and Taylor, L.S. (2006) A Comparison of the Physical Stability of Amorphous Felodipine and Nifedipine Systems. Pharmaceutical Research 23(10):2306-2316. http://dx.doi.org/10.1007/s11095-006-9047-9 31. Hu, Y., Wikström, H., Byrn S.R., and Taylor, L.S. (2006) Analysis of the Effect of Particle Size on Polymorphic Quantitation by Raman Spectroscopy. Applied Spectroscopy 60(9):977-984. http://dx.doi.org/10.1366/000370206778397272 30. Wikström, H., Romero-Torres, S., Wongweragiat, S., Stuart Williams, J.A., Grant, E.R., and Taylor, L.S. (2006) On-Line Content Uniformity Determination of Tablets Using Low-Resolution Raman Spectroscopy. Applied Spectroscopy 60(6):672-681. http://dx.doi.org/10.1366/000370206777670684 29. Salameh, A.K., and Taylor, L.S. (2006) The Role of Deliquescence Lowering in Enhancing Chemical Reactivity in Physical Mixtures. Journal of Physical Chemistry B 110(20):10190-10196. http://dx.doi.org/10.1021/jp0612376 28. Salameh, A.K., Mauer L.J., and Taylor, L.S. (2006) Deliquescence Lowering in Food Ingredient Mixtures. Journal of Food Science 71(1):E10-E16 27. Salameh, A.K., and Taylor, L.S. (2006) Physical Stability of Crystal Hydrates and Their Anhydrates in the Presence of Excipients. Journal of Pharmaceutical Sciences 95(2):446-461. http://dx.doi.org/10.1002/jps.20532 26. Rantanen, J., Wikström, H., Rhea, F.E., and Taylor, L.S. (2005) Improved Understanding of Factors Contributing to Quantification of Anhydrate/Hydrate Powder Mixtures. Applied Spectroscopy 59(7):942-951. http://dx.doi.org/10.1366/0003702054411670 25. Wikström, H., Lewis, I.R., and Taylor, L.S. (2005) Comparison of Sampling Techniques for In-Line Monitoring Using Raman Spectroscopy. Applied Spectroscopy 59(7):934-941. http://dx.doi.org/10.1002/jps.20241 24. Salameh, A.K., and Taylor, L.S. (2005) Deliquescence in Binary Mixtures. Pharmaceutical Research 22(2):318-324. http://dx.doi.org/10.1007/s11095-005-1563-5 23. Rantanen, J., Wikström, H., Turner, R., and Taylor, L.S. (2005) Use of In-Line Near- Infrared Spectroscopy in Combination with Chemometrics for Improved Understanding of Pharmaceutical Processes. Analytical Chemistry 77(2):556-563. http://dx.doi.org/10.1021/ac048842u 22. Hu, Y., Liang, J., Myerson, A., and Taylor, L.S. (2005) Crystallization Monitoring by Raman Spectroscopy: Simultaneous Measurement of Desupersaturation Profile and Polymorphic Form in Flufenamic Acid Systems. Industrial and Engineering Chemistry Research 44(5):1233-1240. http://dx.doi.org/10.1021/ie049745u 21. Wikström, H., Marsac, P.J., and Taylor, L.S. (2005) In-Line Monitoring of Hydrate Formation During Wet Granulation Using Raman Spectroscopy. Journal of Pharmaceutical Sciences 94(1):209-219. http://dx.doi.org/10.1002/jps.20241 20. Ringqvist, A., Taylor, L.S.,Ekelund, K., Ragnarsson, G., Engströme, S., and Axelsson, A. (2003) Atomic Force Microscopy Analysis and Confocal Raman Microimaging of Coated Pellets. International Journal of Pharmaceutics 267(1-2):35 47. http://dx.doi.org/10.1016/j.ijpharm.2003.07.004 19. Santesson, S., Johansson, J., Taylor, L.S., Levander, I., Fox, S., Sepaniak, M., and Nilsson, S. (2003) Airborne Chemistry Coupled with Raman Spectroscopy. Analytical Chemistry 75(9):2177-2180. http://dx.doi.org/10.1021/ac026302w 18. Johansson, J., Pettersson, S. and Taylor, L.S. (2002) Infrared Imaging of Laser-Induced Heating During Raman Spectroscopy of Pharmaceuticals. Journal of Pharmaceutical and Biomedical Analysis 30:1223-1231. http://dx.doi.org/10.1016/S0731-7085(02)00461-2 17. Ahlqvist, M.U.A., and Taylor, L.S. (2002) Water Dynamics in Channel Hydrates Investigated Using H/D Exchange. International Journal of Pharmaceutics 241(2):253-261. http://dx.doi.org/10.1016/S0378-5173(02)00242-9 16. Tong, P., Taylor, L.S., and Zografi, G. (2002) Influence of Alkali Metal Counterions on the Glass Transition Temperature of Amorphous Indomethacin Salts. Pharmaceutical Research 19(5):649-654. http://dx.doi.org/10.1023/A:1015310213887 15. Tang, X.C., Pikal, M.J., and Taylor, L.S. (2002) The Effect of Temperature on Hydrogen Bonding in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers. Pharmaceutical Research 19(4):484-490. http://dx.doi.org/10.1023/A:1015199713635 14. Tang, X.C., Pikal, M.J., and Taylor, L.S. (2002) A Spectroscopic Investigation of Hydrogen Bond Patterns in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers. Pharmaceutical Research 19(4):477-483. http://dx.doi.org/10.1023/A:1015147729564 13. Ahlqvist, M.U.A., and Taylor, L.S. (2002) Water Diffusion in Hydrated Crystalline and Amorphous Sugars Monitored Using H/D Exchange. Journal of Pharmaceutical Sciences 9(3):690-698. http://dx.doi.org/10.1002/jps.10068 12. Broman, E.; Khoo, C., and Taylor, L.S. (2001) A Comparison of Alternative Polymer Excipients and Processing Methods For Making Solid Dispersions of a Poorly Water Soluble Drug. International Journal of Pharmaceutics 222(1):139-151. http://dx.doi.org/10.1016/S0378-5173(01)00709-8 11. Taylor, L.S., and Langkilde F.W., and Zografi, G. (2001) Fourier Transform Raman Spectroscopic Study of the Interaction of Water Vapor with Amorphous Polymers. Journal of Pharmaceutical Sciences 90(7):888-901. http://dx.doi.org/10.1002/jps.1041 10. Taylor, L.S., and Langkilde F.W. (2000) Evaluation of Solid State Forms Present in Tablets by Raman Spectroscopy. Journal of Pharmaceutical Sciences 89(10):1342-1353. http://dx.doi.org/10.1002/1520-6017(200010)89:10<1342::AID-JPS12>3.0.CO;2-X 9. Taylor, L.S., and Zografi, G. (1998) Sugar-Polymer Hydrogen Bond Interactions in Lyophilised Amorphous Mixtures. Journal of Pharmaceutical Sciences 87(12):1615-1621. http://dx.doi.org/10.1021/js9800174 8. Shamblin, S.L., Taylor, L.S., and Zografi, G., and (1998) Mixing Behavior of Colyophilized Binary Systems. Journal of Pharmaceutical Sciences 87(6):694-701. http://dx.doi.org/10.1021/JS9704801 7. Taylor, L.S., and Zografi, G. (1998) The Quantitative Analysis of Crystallinity Using FT-Raman Spectroscopy. Pharmaceutical Research 15(5):755-761. http://dx.doi.org/10.1023/A:1011979221685 6. Taylor, L.S., and York, P. (1998) Effect of Particle Size and Temperature on the Dehydration Kinetics of Trehalose Dihydrate. International Journal of Pharmaceutics 167(1-2):215-221. http://dx.doi.org/10.1016/S0378-5173(98)00065-9 5. Taylor, L.S.; Williams, A.C.; and York, P. (1998) Particle Size Dependent Molecular Rearrangements During the Dehydration of Trehalose Dihydrate-In Situ FT-Raman Spectroscopy. Pharmaceutical Research 15(8):1207-1214. http://dx.doi.org/10.1023/A:011935723444 4. Taylor, L.S., and York, P. (1998) Characterization of the Phase Transitions of Trehalose Dihydrate on Heating and Subsequent Dehydration. Journal of Pharmaceutical Sciences 87(3):347-355. http://dx.doi.org/10.1021/js970239m 3. Taylor, L.S., and Zografi, G. (1997) Spectroscopic Characterization of Interactions between PVP and Indomethacin in Amorphous Molecular Dispersions. Pharmaceutical Research 14(12):1691-1698. http://dx.doi.org/10.1023/A:1012167410376 2. Taylor, L.S.; Williams, A.C.; and Mehta, V., and York, P. (1997) Characterization of Frozen Glucose Solutions. Pharmaceutical Development and Technology 2(4):395-402. 1. Taylor, L.S.; Williams, A.C.; Edwards, H.G.M.; Mehta, V.; Jackson, G.S.; Badcoe, I.G.; and Clarke, A., and York, P. (1995) Sucrose Reduces the Efficiency of Protein Denaturation by a Chaotropic Agent. Biochimica et Biophysica Acta 1253(1):39-46. http://dx.doi.org/10.1016/0167-4838(95)00142-H