SynBERC:Parts: Difference between revisions

Revision as of 12:21, 20 September 2006

This is a draft list of research topics that the SynBERC Parts Thrust is considering for support.
Please contribute & edit with impunity.
We need to get the set of topics correct and then organize ourselves (and anybody else who wants) around getting the work done.

I. Goals

1. Parts collection, registry

2. Parts characterization

3. Parts engineering

a. New function
b. Tune strength, timing
c. Orthogonal, composable function
d. Develop general methods for part redesign

II. Part Families

Transcriptional

repressors, DNA binding proteins
terminators
promoters

Translational

RBS
Riboregulators
mRNA procesing

Degradation

degrons

Secretion

Targeting sequences

Sensing/actuating

protein binding
small molecule ligand binding
light sensing
switches

Assembly

Protein-protein interactions (orthogonal set)

Phosphorylation logic control

Kinases
Phosphatases
Docking motifs
phosphorecognition

Biosynthetic enzymes

Transporters

Cell adhesion

Chassis parts

Vectors
YAC components
Transposon components

@@ Line 14: / Line 14: @@
 *c. Orthogonal, composable function
 *d. Develop general methods for part redesign
+==II.  Part Families==
+===Transcriptional===
+*repressors, DNA binding proteins
+*terminators
+*promoters
+===Translational===
+*RBS
+*Riboregulators
+*mRNA procesing
+===Degradation===
+*degrons
+===Secretion===
+*Targeting sequences
+===Sensing/actuating===
+*protein binding
+*small molecule ligand binding
+*light sensing
+*switches
+===Assembly===
+*Protein-protein interactions (orthogonal set)
+===Phosphorylation logic control===
+*Kinases
+*Phosphatases
+*Docking motifs
+*phosphorecognition
+===Biosynthetic enzymes===
+===Transporters===
+===Cell adhesion===
+===Chassis parts===
+*Vectors
+*YAC components
+*Transposon components