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<html> <align=left><h1 style="color:maroon">Research</h1></align> </html> Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components: a) the modification of biochemical pathways inside cells and b) the rigorous evaluation of the resulting cellular phenotypes.


Our most recent research has been focussed on the following topics:



<li><b><a href="Biochemicals.shtml">Metabolic Engineering of <i>E.Coli</i>

               for the production of biochemicals.</b></a>

<li><b><a href="Inverse.shtml">Inverse Metabolic Engineering</b></a>

<li><b><a href="gTME.shtml">gTME</b></a>

               <li><b><a href="Flux.shtml">Flux Determination</b></a>

<li><b><a href="Hepatocyte.shtml">Hepatocyte Physiology</b></a>

<li><b><a href="Metabolomics.shtml">Metabolomics</b></a>

<li><b><a href="SysBio.shtml">Systems Biology</b></a>

           	To accomplish the above goals we make use of a diverse array of scientific tools and

methods, many of which have also become areas of research for our group:

               <b><a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a></b> - Our group was

one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.


<b><a href="Fluxes.shtml">Methods for intracellular flux determination</a></b>

               - Fluxes are determined by material balancing, NMR fine spectra analysis and

GC-MS measurements.

               <b><a href="Microarray.shtml">DNA microarrays</a></b> - We have developed full 

genome microarrays for <i>Synechocystis</i> Sp., and partial microarrays for

               <i>C. glutamicum</i>, <i>E. coli</i>, and the mouse genomes. 
               <b><a href="BioReactor.shtml">Bioreaction network analysis.</a></b>


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<tr><td width=750 valign="top"> <!---Footer Info Table----> <table width=750 border=0 cellpadding=0 cellspacing=0> <tr><td align="left" width="250" valign="top"> <font color="maroon"><tt>Address</tt></font><br> <small> Massachusetts Institute of Technology<br> Department of Chemical Engineering<br> Cambridge, MA 02139<br> Room 56-469 </small> </td> <td align="center" width="250" valign="top"> <small> <a href="">MIT</a> | <a href="/wiki/Stephanopoulos_Lab">HOME</a><br> Last Modified:<br>Monday, July 10th, 2006 - by <a href="Adrian.shtml">afi</a>. </small> <br> <font color="#990000"><tt></tt></font> </td> <td align="right" width="250" valign="top"> <font color="#990000"><tt>Telephones</tt><br></font> <small> office | 617.258.0398<br> lab | 617.253.6591<br> lab | 617.258.0349<br> lab | 617.253.6521<br> fax | 617.253.3122<br> </small> </td></tr> </table></td></tr> </html>