Sriram Kosuri

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Sri at work


I am curently a Staff Scientist in the Synthetic Biology Platform at the Wyss Institute as a member of the Advanced Technology Team. I was a postdoc in George Church's lab in the Department of Genetics at Harvard Medical School and the Wyss Institute from 2009-2011. From 2007-2009, I worked at a small Cambridge-area startup called Joule Unlimited. I am also on the Board of Directors for OpenWetWare. I previously did a short postdoctoral stint in Mike Laub's lab working on cell cycle in Caulobacter crescentus. Prior to the Laub lab, I was a graduate student in Drew Endy's lab and worked on understanding the development of a simple virus (T7) that infects E. coli. As an undergraduate at UC Berkeley, I worked with Adam Arkin, Dale Kaiser, and Roy Welch on modeling traveling wave formation in M. xanthus.



When It Rains, It Pores
Sriram Kosuri & A. Michael Sismour
ACS Synthetic Biology (2012) doi:10.1021/sb300015f

Gene Assembly from Chip-Synthesized Oligonucleotides
Nikolai Eroshenko*, Sriram Kosuri*, Adam H Marblestone, Nicholas Conway, & George Church
Current Protocols in Chemical Biology (2012) doi:10.1002/9780470559277.ch110190

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
Feng Zhang*, Le Cong*, Simona Lodato, Sriram Kosuri, George Church & Paola Arlotta
Nature Biotechnology (2011) doi:10.1038/nbt.1775

Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips
Sriram Kosuri*, Nikolai Eroshenko*, Emily LeProust, Michael Super, Jeffrey Way, Jin Billy Li & George Church
Nature Biotechnology (2010) 28:1295 doi:10.1038/nbt.1716 News & Views, Cover Art

TABASCO: A single molecule, base-pair resolved gene expression simulator
Sriram Kosuri, Jason Kelly and Drew Endy
BMC Bioinformatics 2007, 8:480 doi:10.1186/1471-2105-8-480

Refactoring bacteriophage T7
Leon Y. Chan*, Sriram Kosuri* and Drew Endy
Molecular Systems Biology 13 September 2005 DOI:10.1038/msb4100025
URL PDF reprint News & Views October 2004 version


  • Developing technologies on making biology easier to engineer.
  • Enabling the design, construction, and use of biological organisms for the purposes of further scientific understanding; keeping extremely aware of the use of engineered biological organisms for other purposes.
  • Understanding those aspects of biological design that allow for certain robust features of development in the face of large intrinsic and extrinsic variation specifically on non-evolutionary time-scales (I am currently giving up on the past. That may change in the future.).
  • Property rights as related to biological information and organisms; understanding and reforming current and future frameworks; I really like these people
  • OpenWetWare of course!

Past Projects

Rebuilding T7

TABASCO -- A single molecule base-pair resolved gene expression simulator

Measure and Models of T7 Infection

How does T7 deal with Uncertainty

T7.2 Tests

Interesting Stuff

The beginnings of a blog.

See my interesting stuff page

Post-doctoral Fellowships

A failed Research Plan for a job at Harvard's CGR

My Thesis!

My contributions to OWW

Sriram Kosuri/temp


Phone: still waiting
OWW users: Post a message on my talk page, or send me an email.
Email: Sri Kosuri's Email.jpg
Harvard Medical School
Genetics Department
New Research Building (NRB) Rooms 232
77 Ave. Louis Pasteur
Boston, MA 02115 USA


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