Sobeck Lab

From OpenWetWare
Revision as of 11:02, 12 January 2012 by Alexandra Sobeck (talk | contribs) (WELCOME TO THE SOBECK LAB)
Jump to: navigation, search


Home/Research        Contact        Lab Members        Publications        Talks        Protocols        Internal       


We are interested in signaling pathways that contribute to the maintenance of genomic stability in our cells and prevent cancer susceptibility in humans. We are studying DNA repair pathways that are activated during the S-phase of the cell cycle when chromosomes replicate.

Our research centers on the Fanconi Anemia (FA) and Breast Cancer associated (BRCA1, BRCA2) repair pathways that are suspected have crucial functions during DNA replication, DNA repair, and cell cycle checkpoint activation. FA patients born with mutations in FA genes have highly elevated risk to develop certain types of cancers including acute myeloid leukemia (AML) and various types of solid tumors. Acquired mutations and silencing of FA genes have been found in different cancers in the general population and the FA genes are thus considered "caretakers" of our genome. Our goal is to understand the molecular functions of the FA/BRCA proteins (currently 15 FA/BRCA genes are known) and to elucidate how these proteins communicate with other members of the DNA damage response network to control and suppress genomic instability.

Our lab uses a combination of human cell-based assays and extracts prepared from eggs of the african clawed frog, Xenopus laevis. These extracts are naturally cell-cycle synchronized and abel to replicate and repair DNA in a test tube, providing us with a cell-free system that can be manipulated in many ways and allows us to ask specific questions about functions of individual FA/BRCA proteins during the DNA damage response.

Sobeck lab FA pathway 2012-1.jpg

Alex Lab Oct 2010.jpg

In this picture (left to right): Rose Kantor, Charlene Fares, Brittany Feia, Archana Sareen, Jordan Becker, Indrajit Chaudhury, Nicki Adams, Alex Sobeck

Lab News

!! Mark your calendars for the Fanconi Anemia Research Fund Symposium from Oct 20-23 in Barcelona Spain !!


Useful links