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Refereed Publications

  1. Michener JK, Thodey K, Liang JC. 2011. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Met. Eng. doi:10.1016/j.ymben.2011.09.004
  2. Liang JC, Bloom RJ, Smolke CD. 2011. Engineering biological systems with engineered RNA molecules. Mol. Cell. 43: 915-26.
  3. Babiskin AH, Smolke CD. 2011. Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity. Nuc. Acids Res. doi: 10.1093/nar/gkr445.
  4. Smolke CD, Silver PA. 2011. Informing biological design by integration of systems and synthetic biology. Cell. 144: 855-9.
  5. Babiskin AH, Smolke CD. 2011. Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules. Nuc. Acids Res. doi: 10.1093/nar/gkr090.
  6. Babiskin AH, Smolke CD. 2011. A synthetic library of RNA control modules for predictable tuning of gene expression in yeast. Mol. Sys. Biol. 7:471.
  7. Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD. 2010. Design of small molecule-responsive miRNAs based on structural requirements for Drosha processing. Nuc. Acids Res. doi:10.1093/nar/gkq829.
  8. Culler SJ, Hoff KG, Smolke CD. 2010. Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins. Science. 330: 1251-5. Perspective: Cell biology. The case for RNA. 330: 1185-6.
  9. Chen YY, Jensen MC, Smolke CD. 2010. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc. Natl. Acad. Sci. USA. 107: 8531-6.
  10. Culler SJ, Hoff KG, Voelker RB, Berglund JA, Smolke CD. 2010. Feature Article: Functional selection and systematic analysis of intronic splicing elements identifies active sequence motifs and associated splicing factors. Nuc. Acids Res. 38: 5152-65.
  11. Hoff KG, Culler SJ, Nguyen PQ, McGuire RM, Silberg JJ, Smolke CD. 2009. In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2. Chem. Biol. 16: 1299-308. Commentary: Lights on iron-sulfur clusters. 16: 1213-4.
  12. Beisel CL, Smolke CD. 2009. Design principles for riboswitch function. PLoS Comp. Biol. 5: e1000363.
  13. Win MN, Liang JC, Smolke CD. 2009. Frameworks for programming biological function through RNA parts and devices. Chem. Biol. 16: 298-310.
  14. Bayer TS, Hoff KG, Beisel CL, Lee JJ, Smolke CD. 2009. Synthetic control of a fitness tradeoff in yeast nitrogen metabolism. J. Biol. Eng. 3: 1.
  15. Hoff KG, Goodlitt R, Li R, Smolke CD, Silberg JJ. 2009. Fluorescence detection of a protein-bound 2Fe2S cluster. Chembiochem. 10: 667-70.
  16. Beisel CL, Bayer TS, Hoff KG, Smolke CD. 2008. Model-guided design of ligand-regulated RNAi for programmable control of gene expression. Mol. Sys. Biol. 4: 224. News and Views: Small hairpin RNA as a small molecule sensor. 4: 227.
  17. Hawkins KM, Smolke CD. 2008. Cover article: Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat. Chem. Biol. 4: 564-73. News and Views: From yeast to alkaloids. 4: 524-5.
  18. Win MN, Smolke CD. 2008. Higher-order cellular information processing with synthetic RNA devices. Science. 322: 456-60. Perspective: Cell biology. RNA computing in a living cell. 322: 387-8.
  19. Win MN, Smolke CD. 2007. From the cover: A modular and extensible RNA-based gene-regulatory platform for engineering cellular function. Proc. Natl. Acad. Sci. USA. 104: 14283-8. Commentary: Targeted cleavage: tuneable cis-cleaving ribozymes. 104: 14881-2. Erratum: Proc. Natl. Acad. Sci. USA. 2009. 106: 15514. (An early online correction was published here.)
  20. Win MN, Klein JS, Smolke CD. 2006. Codeine-binding RNA aptamers and rapid determination of their binding constants using a direct coupling surface plasmon resonance assay. Nuc. Acids Res. 34: 5670-82.
  21. Pfleger BF, Pitera DJ, Smolke CD, Keasling JD. 2006. Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes. Nat. Biotech. 24: 1027-32.
  22. Hawkins KM, Smolke CD. 2006. The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae. J. Biol. Chem. 281: 13485-92.
  23. Bayer TS, Smolke CD. 2005. Programmable, ligand-controlled riboregulators of eukaryotic gene expression. Nat. Biotech. 23: 337-43. News and Views: Plug and play with RNA. 23: 306-7.
  24. Smolke CD, Keasling JD. 2002. Effect of gene location, mRNA secondary structures, and RNase sites on expression of two genes in an engineered operon. Biotech. Bioeng. 80: 762-76.
  25. Smolke CD, Keasling JD. 2002. Effect of copy number and mRNA processing and stabilization on transcript and protein levels from an engineered dual-gene operon. Biotech. Bioeng. 78: 412-24.
  26. Smolke CD, Khlebnikov A, Keasling JD. 2001. Effects of transcription induction homogeneity and transcript stability on expression of two genes in a constructed operon. Appl. Micro. Biotech. 57: 689-96.
  27. Smolke CD, Martin VJJ, Keasling JD. 2001. Controlling the metabolic flux through the carotenoid pathway using directed mRNA processing and stabilization. Met. Eng. 3: 313-21.
  28. Smolke CD, Carrier TA, Keasling JD. 2000. Coordinated, differential expression of two genes through directed mRNA cleavage and stabilization by secondary structures. Appl. Environ. Microbiol. 66: 5399-405.

Please Note:
An early online correction to (PNAS. 2007. 104:14283-8) has been published here.
Additional detail on data processing and raw data for (Science. 2008. 322:456-60.) is provided here.

Non-Refereed Publications

  1. Thodey K, Smolke CD. 2011. Cell Biology. Bringing it together with RNA. Science. 333: 412-3.
  2. Smolke CD. 2009. Building outside of the box: iGEM and the BioBricks Foundation. Nat. Biotech. 27:1099-102.
  3. Smolke CD. 2009. Cell Biology. It’s the DNA that counts. Science. 324: 1156-7.
  4. Win MN, Smolke CD. 2007. RNA as a versatile and powerful platform for engineering genetic regulatory tools. Biotechnology and Genetic Engineering Reviews. 24: 311-46.
  5. Baker D, Church G, Collins J, Endy D, Jacobson J, Keasling J, Modrich P, Smolke C, Weiss R. 2006. Engineering life: building a Fab for biology. Scientific American. 294: 44-51.
  6. Martin VJJ, Smolke CD, Keasling JD. 2002. Redesigning cells for the production of complex organic molecules. ASM News. 68: 336-43.

Books and Book Chapters

  1. Liang JC, Smolke CD. 2011. Rational design and tuning of ribozyme-based devices. In: Hartig J, editor. Methods in Molecular Biology. In press.
  2. Win MN, Liang JC, Smolke CD. 2010. Frameworks for programming RNA devices. In: Mayer G, editor. The Chemical Biology of Nucleic Acids. U.K.: John Wiley & Sons, Ltd. pp. 323-38.
  3. Win MN, Smolke CD. 2009. Regulating gene expression through engineered RNA technologies. In: Smolke CD, editor. Handbook for Metabolic Pathway Engineering: Tools and Applications. San Diego: CRC Press.
  4. Smolke CD, Martin VJJ, Keasling JD. 2004. Tools for metabolic engineering in Escherichia coli. In: Baneyx F, editor. Protein Expression Technologies: Current Status and Future Trends. U.K.: Horizon Scientific Press.

Edited Works in Print

  1. Smolke CD, editor. 2009. Handbook for Metabolic Pathway Engineering: Fundamentals (volume I). San Diego: CRC Press.
  2. Smolke CD, editor. 2009. Handbook for Metabolic Pathway Engineering: Tools and Applications (volume II). San Diego: CRC Press.