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Jon Sack, Ph.D.
 
 
 
==Research interests==
 
Electrical signaling in living cells controls a wide variety of arguably important physiological processes such as feeling, thinking, and heartbeat. Electrophysiological signals are created by proteins known as ion channels, and modulating the behavior of ion channels will alter the processes they control.  The goal of my research program is to develop modulators selective for ion channel subtypes, to more precisely alter electrophysiological signals and identify channel subunits that generate native currents.  Establishing the molecular identity of voltage-gated potassium (Kv) channels has been a particularly challenging problem: mammalian channels arise from a family of more than 40 genes, and pore-forming subunits can assemble as heterotetramers. Despite substantial and enduring efforts, few modulators of Kv channel activity have been discovered that are highly selective between  channel subtypes.  This is perhaps due to a high degree of sequence conservation between subfamily members in functionally important transmembrane segments. Our research efforts seek to enhance the selectivity of channel modulators by covalent attachment to benign, yet well-targeted, biologics.
 
 
 
==Education==
 
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* Ph.D., Stanford University, Department of Biological Sciences
 
* B.A., Reed College, Biochemistry
 
 
 
==Institutional Affiliation==
 
 
 
Assistant Professor
 
 
 
Department of Physiology & Membrane Biology
 
 
 
School of Medicine
 
 
 
University of California
 
 
 
4126 Tupper Hall
 
 
 
One Shields Avenue
 
 
 
Davis, California 95616
 
 
 
530.752.4131 tel
 
530.752.5314 lab tel
 
530.752.5423 fax
 
 
 
jsack@ucdavis.edu
 
 
 
==Math Practice==
 
 
 
''x''<sup>2</sup>+''y''<sup>2</sup>=''z''<sup>2</sup>
 
{{math|''x''<sup>2</sup>+''y''<sup>2</sup>{{=}}''z''<sup>2</sup>}}
 
<math>x^2+y^2=z^2</math>
 

Revision as of 06:28, 26 October 2013

http://sj12g4.wix.com/team-fukuoka