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Proteomic Analysis of Connective Tissue Sarcoma: We have developed methods for proteomic analysis of formalin-fixed, paraffin embedded (FFPE) dense connective tissues (bone, cartilage and tumors). Our unique methods of protein extraction are coupled with mass spectrometry for proteomic analyses. These powerful methods, and the use of archival tissues, allow us to evaluate even rare musculoskeletal tumors. In this way, we are able to carry out translation research that directly addresses questions of clinical orthopaedic oncology.
Metastatic Mechanisms of Osteosarcoma: We are investigating integrin mediated and matrix metalloproteinase (MMP) dependent mechanisms of osteosarcoma metastasis using genetically modified cells and an in vivo model.
Polymer Scaffolds for Cellular Attachment: We are evaluating cellular attachment to and proliferation on various nano- and micro-scale topologies made with the polymer parylene C. This work is being carried out in collaboration with Dr. Akhlesh Laktakia. Using a method pioneered by Dr. Laktakia, the parylene C can be deposited in a controlled manner to create Sculptured Thin Films (STFs) with very specific morphologies (chiral, chevron, etc.). We are refining the morphologies to best support cellular in growth. The ultimate goal is to enhance tissue integration of medical implants.