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Proteomic Analysis of Connective Tissue Sarcoma: We have developed a method for proteomic analysis of formalin-fixed, paraffin embedded (FFPE) connective tissues (bone and cartilage). This powerful method allows us to evaluate even rare musculoskeletal tumors. With these methods, we perform proteomic analysis using mass spectrometry of FFPE sarcoma tumor samples. We employ laser capture microdissection to collect samples from complex tissue samples.
Metastatic Mechanisms of Osteosarcoma: We are investigating integrin mediated and matrix metalloproteinase (MMP) dependent mechanisms of osteosarcoma metastasis using genetically modified cells and an in vivo model.
Polymer Scaffolds for Cellular Attachment: We are evaluating cellular attachment to and proliferation on various nano- and micro-scale topologies made with the polymer parylene C. This work is being carried out in collaboration with Dr. Akhlesh Laktakia. Using a method pioneered by Dr. Laktakia, the parylene C can be deposited in a controlled manner to create Sculptured Thin Films (STFs) with very specific morphologies (chiral, chevron, etc.). We are refining the morphologies to best support cellular in growth. The ultimate goal is to enhance tissue integration of medical implants.