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Metastatic Mechanisms of Osteosarcoma: We are investigating integrin mediated and matrix metalloproteinase (MMP) dependent mechanisms of osteosarcoma metastasis.
Sarcoma Biomarker Identification: We are performing proteomic analysis by mass spectrometry of sarcoma tumor samples using laser capture microscopy and tissue microarrays.
Polymer Scaffolds for Cellular Attachment: We are evaluating cellular attachment to and proliferation on various nano- and micro-scale topologies made with the polymer parylene C. This work is being carried out in collaboration with Dr. Akhlesh Laktakia. Using a method pioneered by Dr. Laktakia, the parylene C can be deposited in a controlled manner to create Sculptured Thin Films (STFs) with very specific morphologies (chiral, chevron, etc.). We are refining the morphologies to best support cellular in growth. The ultimate goal is to enhance tissue integration of medical implants.