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Revision as of 07:14, 10 June 2013


Contact Info

Kaifu Chen
  • Kaifu Chen
  • Dan L. Duncan Cancer Center,Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, suite 450A, Houston, Texas,77030.
  • kaifuc at bcm dot edu


  • 2009, PhD, Beijing Institute of Genomics, Chinese Academy of Sciences
  • 2004, BS, Institute of Physics, Nankai University.


  • 2009- present, Postdoctorial Associate, BCM, Houston, Texas, USA.
  • 2008-2009, Research Associate, KAUST, Riyadh, Saudi Arabia.

Research interests

Based on high throughput sequencing and bioinformatic platforms, our research focus on mechanisms of gene expression regulation and their implications in cancers, heart diseases, aging, and so on.


^ first or co-first authorship

  1. Chen, X., Cui, D., Papusha, A., Zhang, X., Chu, C., Tang, J., Chen, K., Pan, X., Ira, G., The Fun30 nucleosome remodeler promotes resection of DNA double-strand break ends. Nature. Accepted.
  2. Barber, M. F., Michishita-Kioi, E., Xi, Y., Tasselli, L., Kioi, M., Moqtaderi, Z., Tennen, R. I., Chen, K., et al. (2012). SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. doi:10.1038/nature11043
  3. Badeaux, A. I., Yang, Y., Cardenas, K., Vemulapalli, V., Chen, K., Kusewitt, D., Richie, E., et al. (2012). Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. The Journal of biological chemistry, 287(1), 429–437. doi:10.1074/jbc.M111.271163
  4. Kuo, A. J.^, Cheung, P^., Chen, K^., Zee, B. M., Kioi, M., Lauring, J., Xi, Y., et al. (2011). NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming. Molecular cell, 44(4), 609–620. Elsevier. doi:10.1016/j.molcel.2011.08.042
  5. Huang, Z., Chen, K., Xu, T., Zhang, J., Li, Y., Li, W., Agarwal, A. K., et al. (2011). Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryotic cell, 10(11), 1536–1544. doi:10.1128/EC.05170-11
  6. Ma, L., Chen, K., Meng, Q., Liu, Q., Tang, P., Hu, S., & Yu, J. (2011). An evolutionary analysis of trypanosomatid GP63 proteases. Parasitology research. doi:10.1007/s00436-011-2348-x
  7. Meng, Q., Chen, K., Ma, L., Hu, S., & Yu, J. (2011). A systematic identification of Kolobok superfamily transposons in Trichomonas vaginalis and sequence analysis on related transposases. Journal of genetics and genomics = Yi chuan xue bao, 38(2), 63–70. doi:10.1016/j.jcg.2011.01.003
  8. Chen, K^., Wang, L., Yang, M., Liu, J., Xin, C., Hu, S., & Yu, J. (2010). Sequence signatures of nucleosome positioning in Caenorhabditis elegans. Genomics, proteomics & bioinformatics / Beijing Genomics Institute, 8(2), 92–102. doi:10.1016/S1672-0229(10)60010-1
  9. Yang, M., Zhang, X., Liu, G., Yin, Y., Chen, K., Yun, Q., Zhao, D., et al. (2010). The complete chloroplast genome sequence of date palm (Phoenix dactylifera L.) PloS one, 5(9), e12762. doi:10.1371/journal.pone.0012762
  10. Chen, K^., Meng, Q., Ma, L., Liu, Q., Tang, P., Chiu, C., Hu, S., et al. (2008). A novel DNA sequence periodicity decodes nucleosome positioning. Nucleic acids research, 36(19), 6228–6236. doi:10.1093/nar/gkn626