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'''The Ratner Lab'''
Revision as of 06:50, 10 October 2006
The Ratner Lab
We investigate the pathogenesis of infectious diseases, with a focus on bacterial diseases affecting children. Using a variety of techniques, we are currently attempting to answer questions in four main areas:
Innate immune responses to bacterial colonization The mucosal surfaces of humans are simultaneously colonized with a vast number of microbial species yet are able to distinguish species, or combinations of species, that may pose a threat. How do the epithelial cells that line these anatomic spaces integrate these signals and initiate innate immune responses? What specific bacterial and host products are essential to proper functioning of this system? How do these responses affect the composition of the normal flora at mucosal surfaces?