Difference between revisions of "Prince:Research"

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m (The Dynamic Proteome)
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==The Dynamic Proteome==
 
==The Dynamic Proteome==
  
Create predictive models of cellular behaviour.
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Our aim is to create predictive models of cellular behaviour, with a focus on modelling signal transduction dynamics.
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===Protein Protein Interactions===
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Proteins interact with one another in order to transmit signals from the outside environment (signal transduction), form complex molecular machines, and localize to specific areas of the cell.  Current methods for capturing protein-protein interactions (PPIs) lack context and/or specificity.  We are developing methods that will enable us to capture ''in vivo'' PPIs involving new biochemical, mass spectrometric, and computational techniques.
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===Protein post-translational modifications===
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===Measuring cellular state===
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===Systems Biology===

Revision as of 14:52, 17 March 2010

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The Dynamic Proteome

Our aim is to create predictive models of cellular behaviour, with a focus on modelling signal transduction dynamics.

Protein Protein Interactions

Proteins interact with one another in order to transmit signals from the outside environment (signal transduction), form complex molecular machines, and localize to specific areas of the cell. Current methods for capturing protein-protein interactions (PPIs) lack context and/or specificity. We are developing methods that will enable us to capture in vivo PPIs involving new biochemical, mass spectrometric, and computational techniques.

Protein post-translational modifications

Measuring cellular state

Systems Biology