- An important secondary amine used as precursor to alkylamines with a aryl-ketone (heteroarylalkyl) moeity when the reaction is performed in presence of a cyanide as the nitrogen substitution group .
- In organic ketone-amine reactions, piperidine may participate in hydrogenation of C=N double bounds where the N-substituted chiral imine may be converted to a enamine, the tautomeric form of a imine. 1
Reductive alkylation of N-aryl substituted imines via piperidine-derived enamines
- Stork-Enamine alkylation: http://en.wikipedia.org/wiki/Stork_enamine_alkylation