OpenSourceMalaria:Other GSK Series Under Consideration

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Other GSK Series Under Consideration

The team have focused on the synthesis and evaluation of two series (the aryl pyrroles and aminothienopyrimidines) to date. The focus of the project could change quite rapidly following the receipt of new biological data (for highly active or inactive compounds). This page highlights other GSK compounds from the TCAMS data that look attractive.

TCMDC 137332

Scheme 1: TCMDC 137332

InChI=1S/C17H18ClNO2/c1-17(2,3)16(20)19-14-6-4-5-7-15(14)21-13-10-8-12(18)9-11-13/h4-11H,1-3H3,(H,19,20) ClC(C=C1)=CC=C1OC2=CC=CC=C2NC(C(C)(C)C)=O

Citations for exact structure search: DOI:10.1021/ml200135p – GSK Paper on Open Innovation WO 1994-GB1409 – Preparation of anti-atherosclerotic1diaryl compound, The Wellcome Foundation

InChi Search: No hits on Google

Citations for sub-structure search: WO 2000-EP1224 – Preparation of phenyl and pyridinyl derivatives as NK-1 receptor antagonists, 2 F. Hoffmann La Roche ComGenex Compound (Scheme 2)

Scheme 2: ComGenex Compound

InChI=1S/C17H17Cl2NO2/c1-17(2,3)16(21)20-13-6-4-5-7-15(13)22-14-9-8-11(18)10-12(14)19/h4-10H,1-3H3,(H,20,21) ClC(C=C1)=CC(Cl)=C1OC2=CC=CC=C2NC(C(C)(C)C)=O