Difference between revisions of "OSDDMalaria:Arylpyrazole Series"

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(Synthesis: eln links)
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=== Synthesis ===
 
=== Synthesis ===
  
The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine. ELN entries [http://malaria.ourexperiment.org/uri/c0 PMY 43-1]  [http://malaria.ourexperiment.org/uri/c4 PMY 44-1] for the core synthesis and hydrolysis respectively.  
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The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine. See ELN entries [http://malaria.ourexperiment.org/uri/c0 PMY 43-1]  [http://malaria.ourexperiment.org/uri/c4 PMY 44-1] for the core synthesis and hydrolysis respectively.  
  
 
[[Image:PMY43-1.png|thumb|center|450px|Synthesis of pyrazole core]]
 
[[Image:PMY43-1.png|thumb|center|450px|Synthesis of pyrazole core]]

Latest revision as of 22:16, 4 April 2012

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Aryl Pyrazole Sub-series

The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.


ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar:


Other compounds of interest from PubChem:

Synthesis

The core can be synthesised with apparent ease from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine. See ELN entries PMY 43-1 PMY 44-1 for the core synthesis and hydrolysis respectively.

Synthesis of pyrazole core