Difference between revisions of "OSDDMalaria:Arylpyrazole Series"

From OpenWetWare
Jump to: navigation, search
m (Aryl Pyrazole Sub-series)
(Synthesis)
Line 16: Line 16:
 
=== Synthesis ===
 
=== Synthesis ===
  
Core: [http://dx.doi.org/10.1002/jhet.5570240634 Synthesis]
+
The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine.
 +
 
 +
[[Image:PMY43-1.png|thumb|center|450px|Synthesis of pyrazole core]]

Revision as of 21:24, 20 March 2012

Malaria Scheme.png

Malaria Home        OSM So Far        Compound Series        Links        Open Source Research Home        Tech Ops        FAQ       


Aryl Pyrazole Sub-series

The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.


ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar:


Synthesis

The core can be synthesised with apparent ease from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine.

Synthesis of pyrazole core