OHSU Knight Cancer Institute Research Groups:OCI Cancer Journal Club

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Equipped with his five senses, man explores the universe around him and calls the adventure Science.  ~Edwin Powell Hubble, The Nature of Science, 1954

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Objectives of the OHSU Cancer Biology Journal Club

Cross-departmental journal club composed of students, postdocs, fellows and clinical and basic science faculty with shared interest in basic principles, emerging discoveries, and new therapeutic approaches in Cancer Biology. The goals of the meetings are to:

  • Critically evaluate new cutting edge literature on mechanisms underlying the development and maintenance of cancer to inform the development of new therapeutics. Papers should be paradigm shifting and set a backdrop for discussion into therapeutics facilitated by the clinical attendees.
  • Provide students, postdocs and fellows with training and interactions with faculty interested in Cancer Biology and emerging therapeutics

KCI CJC Information

Want to join us? All are invited!

  • To get on the listserve:
go to the following web site:
follow instructions for subscribing
  • To send out your paper
Send an e-mail to 'oncobioATohsu.edu' with your paper attached
  • When and where we meet
MacHall 2136
Thursdays noon-1 PM
Lunch provided by KCI
  • Organizer contact information:
Rosie Sears-searsr@ohsu.edu
Charlie Lopez- lopezc@ohsu.edu

Member Labs and Affiliations

Lopez Lab Hem Onc

Sears Lab

Hoatlin Lab

Thayer Lab

Wong Lab

Lloyd Lab CROET

McCullough Lab CROET


  • Scheduling In Progress
Date Presenters Topic Links & Comments
10/1/2013 Organization
1/17/2013 Spencer Watson Mitochondrial dynamics regulates migration and invasion of breast cancer cells [1]
1/24/2013 Ping Wang Oncogenic Kras-Induced GM-CSF Projection Promotes the Development of Pancreatic Neoplasia [2] [3]
1/31/2013 Aaron Wortham Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration Luga V et al Cell 151, 1542-1556 (2012)
2/7/2013 Jeff Wu MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrinsubunits [4]
2/14/2013 Tiffany Devine The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites [5]
2/21/2013 Ellie Juarez Poly(beta-aminoester) nanoparticle-delivery of p53 has activity against small cell lung cancer in vitro and in vivo Molecular Cancer Therapeutics [6]
2/28/2013 Tim Butler tumor heterogeneity, focusing mostly on a recent science paper (Kreso 2013) which shows serially passages clones responding differently to chemotherapy Kreso 2013Gerlinger 2012
3/7/2013 Toni West Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties Schwitalla S et al Cell 152, 25-38 (2013)
3/14/2013 Jared Fischer Intestinal label-retaining cells are secretory precursors expressing Lgr5 [7]
3/21/2013 Mushui Dai Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence. [8]
4/4/2013 Nathalie Javidi-Sharifi Tumor Stem Cells Generate Vasculature [9] [10]
4/11/2013 Amy Farrell Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer Stefan Eser, et al
4/18/2013 Trevor Levin DNA damage foci formation around double strand breaks and regulation of NHEJ and HR repair mechanisms ZimmermanVirgilioKukas
4/25/2013 Kevin Watanabe-Smith "Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models" [11] [12]
5/2/2013 Stacey Lin Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion [13]
5/9/2013 Juan Liang Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53 [14]
5/16/201 Xiaoxin Sun Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP [15]
5/23/2013 Dr. Charles Lopez CANCELED DUE TO RESEARCH WEEK
5/30/2013 Mahnaz Janghorban Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer Dong et al
6/6/2013 Marcus Calkins The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation [16]