Melissa Kemp

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Melissa Kemp (BE postdoctoral), in collaboration with Lucia Wille, John Burke, Christina Lewis

Investigation of the signaling dynamics and cytokine responses resulting from stimulation of the T cell receptor via ligands of varying avidity. Using a systems approach, we have generated a large dataset characterizing the multivariate relationships between ligand avidity, signaling dynamics and IL-2 production in a murine T cell hybridoma line. Partial least squares regression analysis leads to a predictive model of IL-2 production in our system.