My name is Maureen Hoatlin, and I'm currently at Oregon Health and Science University in Portland, Oregon. My lab joined OpenWetWare in 2006. We use OWW almost every day for our lab website, sharing our reagents and protocols, and organizing courses and seminars series. You can email me through OpenWetWare.
We are interested in understanding how cells maintain genomic stability. One of the mechanisms that regulates this critical process is defective in Fanconi anemia (FA), a genetic model for human susceptibility to cancer. FA is a rare but devastating multi-gene disease thought to have an underlying defect in DNA interstrand crosslink repair.
Our lab pioneered the use of cell-free assays for FA proteins in extracts from Xenopus eggs. These extracts allow analysis of FA protein function and post-translational modifications in a context that is permissive for naturally-regulated DNA synthesis. The recruitment of Fanconi proteins with chromatin in S-phase is providing us with a biochemical platform for elucidating the molecular function of the Fanconi proteins during the DNA damage response.
OWW Pages in Progress
- B.S. in Chemistry from Old Dominion University
- Analytical Chemist SRI International in Menlo Park. Analysis of natural products and nucleoside anti-tumor agents (my favorite compound)
- Research associate at Genentech, Inc, starting in nucleoside chemistry but defecting quickly to molecular biology to clone and express proteins of clinical interest, including work on recombinant subunit vaccines for treatment of Rabies, Polio, HIV, and Foot and Mouth Disease. We went to Plum Island to get FMDV cloned. The picture of us (see me in circle) in the Plum Island containment facility has a life of its own.
- Graduate research at OHSU with David Kabat, focusing on retroviral mediated pathogenesis in hematopoiesis and genes that control host susceptibility to cancer
- Postgraduate work in Hematology and Oncology, Founding Director of the OHSU Cancer Center Cell Culture Facility
- Visiting scientist at the Free University of Amsterdam in 1998-1999
- Joined Molecular Medicine as an Assistant Professor in 2000
- Biochemistry and Molecular Biology absorbed components of Mol Med (including me) in 2005