Difference between revisions of "Lauffenburger:Laura Sontag"

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activated by oncogenic Ras.  The Ras signaling cascade
 
activated by oncogenic Ras.  The Ras signaling cascade
 
constitutes a major pathway shown to be deregulated due to activating
 
constitutes a major pathway shown to be deregulated due to activating
mutations in 30% of all human tumors.  The vast majority of mutations occur in K-ras.  We use genetically engineered mice that harbor a conditional,
+
mutations in 30% of all human tumors.  The vast majority of mutations occur in the K-ras gene.  We use genetically engineered mice that harbor a conditional,
 
activatable K-ras allele as a model of human cancer.
 
activatable K-ras allele as a model of human cancer.
  

Revision as of 17:14, 5 February 2006

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Laura Sontag (Computational and Systems Biology doctoral student)

Advisors: Professors Peter Sorger (Biology/BE, MIT) and Douglas Lauffenburger (BE/ChemE/Biology, MIT), in collaboration with Professor Tyler Jacks (Biology/Center for Cancer Research, MIT)


Computational and experimental analysis of mitogenic signaling pathways activated by oncogenic Ras. The Ras signaling cascade constitutes a major pathway shown to be deregulated due to activating mutations in 30% of all human tumors. The vast majority of mutations occur in the K-ras gene. We use genetically engineered mice that harbor a conditional, activatable K-ras allele as a model of human cancer.


Email: sontag {AT} mit {DOT} edu

Laura Sontag's Homepage