Difference between revisions of "LabName:Alcazar"

From OpenWetWare
Jump to: navigation, search
 
(264 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:Alcazar_lab.png|900px]]
+
[[Image:Alcazarlab_logo.jpg|900px]]
<div style="padding: 40px; color: #ffffff; width: 800px">
+
<div style="padding: 40px; color: #ffffff; width: 900px">
 
<font face="calibri" style="color:#000000" font size="3">
 
<font face="calibri" style="color:#000000" font size="3">
 +
**** New lab webpage hosted at University of Barcelona servers***
 +
 +
Please visit: http://www.ub.edu/portal/web/dp-bsma/stress
  
 
<div id="right menu" style="width:250px; padding: 1em 2em; float:left;">
 
<div id="right menu" style="width:250px; padding: 1em 2em; float:left;">
 
{{Template:Alcazar Vertical Menu}}
 
{{Template:Alcazar Vertical Menu}}
 
</div>
 
</div>
 +
<font face="calibri" style="color:#000000" font size="4"><br>
 +
'''''Dear visitor,'''''<br>
 +
<br> Welcome to the Molecular Genetics of Plant Stress Tolerance Lab (Ruben Alcazar & A.F. Tiburcio Labs) ''' at the Department of Biology, Healthcare & Environment of the University of Barcelona. <br><br>
 +
We're a recently created joint research group that investigates the '''adaptation of plants to local environments'''. We focus on the evolutionary adaptation of plant populations to '''abiotic and biotic stresses''', which are major challenges for plant survival under the current climate change predictions. Derived from our research, we investigate ways for improving stress protection.<br>
 +
<font face="calibri" style="color:#000000" font size="4"><br>
 +
For a more detailed view of our research, please have a look at our [http://alcazar.openwetware.org/Research.html Research Projects] and [http://alcazar.openwetware.org/Publications.html Scientific Publications] sections. You can follow an updated list of our activities and publications in the NEWS section below. For any other enquires, do not hesitate to contact us directly.<br><br>
 +
<font face="helvetica" style="color:#000000" font size="2">
 +
 +
 +
<br><br><br><br><br><br><br><br>
 +
 +
----
 +
<font face="helvetica" style="color:#000001" font size="3">
  
<font face="calibri" style="color:#000000" font size="6">
 
 
<br>
 
<br>
'''''Plant-Environment Interactions'''''<br>
+
'''1. POLYAMINE PERCEPTION AND SIGNALING'''
<font face="calibri" style="color:#C0C0C0" font size="4">
+
<div id="right menu" style="width:275px; padding: 1em 2em; float:left;">
''Challenges and Consequences of Climate Change (C4)''<br>
+
[[Image:Polyamines.jpg|300px]]
<font face="arial" style="color:#DBA901" font size="3"><br>
+
</div>
----
 
* Our lab is committed to finding solutions for future '''C'''hallenges and '''C'''onsequences of '''C'''limate '''C'''hange: '''the four C's.''' <br><br>
 
* We approach this by studying '''plant''' '''tolerance''' and '''resistance''' in diverse environments. <br><br>
 
* Why in plants? Because plants are primary sources of '''food''' and their adaptation to new environments is a prerequisite for the establishment of '''life''' as we know on earth.<br>
 
<font face="calibri" style="color:#000000" font size="4">
 
 
<br>
 
<br>
[[Image:Cccc.png|200px]]
 
[[Image:marie-curie.jpg|200px]]<br><br>
 
<font face="calibri" style="color:#DBA901" font size="5">
 
'''Current activities'''<br><br>
 
<font face="calibri" style="color:#DBA901" font size="4">
 
'''Advance in Knowledge. '''
 
 
<font face="calibri" style="color:#000000" font size="4">
 
<font face="calibri" style="color:#000000" font size="4">
We're interested in genetics of natural variation, population genetics and molecular biology. We're currently studying immune-receptor gene variation and the effect of temperature on modulation of defense in frame of the project DISEASENVIRON (Career Integration Grant, Marie-Curie Actions, EU). <br><br>
+
Our research laboratory has long-standing experience in the field of plant polyamines, for which we performed a number of omics approaches and established genetic evidence for their role in abiotic stress protection.
<font face="calibri" style="color:#DBA901" font size="4">
+
 
'''Applied research. '''
+
 
 +
Our previous research pointed to interactions of polyamines with hormones and other stress-related metabolites. Our current goal is to investigate how polyamines are perceived by the plant, which early signaling components are involved, and how this is shaped by the environment.
 +
 
 +
 
 +
We’re making use of background knowledge from different disciplines to gain insight into polyamine perception and signaling, for which little is known in plants. We’re making use of genetics of natural variation, reverse genetics, molecular biology and plant-microbe interactions to unravel how polyamines are sensed and how this relates to the local microbiota.
 +
 
 +
 
 +
Our final goal is to provide novel approaches for crop protection against abiotic and biotic stresses.
 +
 
 +
 
 +
Key words: stress tolerance, drought, salinity, freezing tolerance, priming, ROS, crop protection, microbiome, rhizosphere, polyamines, natural variation, transcriptional regulation, metabolon, modulon.
 +
 
 +
 
 +
'''2. MOLECULAR EVOLUTION OF DISEASE RESISTANCE IN PLANTS''' <br>
 
<font face="calibri" style="color:#000000" font size="4">
 
<font face="calibri" style="color:#000000" font size="4">
Our lab collaborates with the group of Prof. A.F. Tiburcio to study polyamine homeostasis in plants and its practical applications for inducing stress tolerance against abiotic stresses. <br><br>
+
----
<font face="calibri" style="color:#DBA901" font size="4">
+
In our lab, we make use of the extensive natural variation of [https://en.wikipedia.org/wiki/Arabidopsis_thaliana ''Arabidopsis thaliana''] populations to answer key fundamental questions:
'''Dissemination of Knowledge. '''
+
 
<font face="calibri" style="color:#000000" font size="4">
+
* '''How plants adapt to local environments including the microbiota?'''
For a more detailed view of our research, have a look at our [http://alcazar.openwetware.org/Research.html Research Projects] and [http://alcazar.openwetware.org/Publications.html Scientific Publications] sections. For general public information have a look at [http://alcazar.openwetware.org/Alcazar_Youtube.html +info]. <br><br>
+
* '''How plants maintain variability of genes involved in pathogen recognition and to which extent this variability is caused by the interaction with pathogens?'''
<font face="calibri" style="color:#DBA901" font size="4">
+
* '''How the environment manipulates immune responses? How this affects the above points?'''
'''Transferring knowledge to future generations. '''  
+
 
<font face="calibri" style="color:#000000" font size="4">Follow our University lectures and lab practices in [http://alcazar.openwetware.org/Lectures.html Teaching activities]. <br>
+
 
<br><br>
+
To address these and other questions, we (and others) developed a new model for plant immunity studies based on the use of ''Arabidopsis'' immune-related incompatible hybrids. These are hybrids obtained by crosses of natural ''Arabidopsis'' accessions that exhibit constitutive activation of defense, stunted growth and sterility in the absence of pathogen challenge. Often, such phenotypes are temperature-dependent and suppressed at high temperature.
 +
 
 +
 
 +
These genetic interactions might unravel molecular partners required for proper modulation of defense. Some of these cases are background-dependent and therefore, likely difficult to be observed in classical reference accessions.
 +
 
 +
 
 +
Since some years, we're using the Ler / Kas-2 immune-related hybrid incompatibility as molecular model to answer some of the questions above. The Landsberg (from Gorzów Wielkopolski, Poland)/Kashmir-2 (from Kashmir mountains) incompatibility involves populations in Central Europe and Central Asia which enable to expand our analyses to population scales. We apply population genetics on top of our molecular and biochemical analyses.  
 +
 
  
 +
Derived from our research, we attempt to provide new strategies for crop protection at medium to long-term.
  
  
 
----
 
----
  
<font face="calibri" style="color:#ffcc66" font size="5">  
+
 
 +
 
 +
 
 +
----
 +
<font face="helvetica" style="color:#000000" font size="3">  
 
[[Image:Announcement_alcazar.jpg |100px]] '''News and Announcements e-Board'''<br>
 
[[Image:Announcement_alcazar.jpg |100px]] '''News and Announcements e-Board'''<br>
 
<font face="calibri" style="color:#000000" font size="3"><br>
 
<font face="calibri" style="color:#000000" font size="3"><br>
  Interesados en hacer tesis doctoral/máster en nuestro grupo contacten por e-mail con Rubén Alcázar.
+
  NEWS
  Interested in doing Master/PhD? Contact us by e-mail.
+
Master in Molecular Biotechnology (Trabajo Final de Máster) offers.
 +
  [http://www.ub.edu/portal/web/farmacia/masters-universitaris/-/ensenyament/detallEnsenyament/483691/0 info]
 +
  Contact us directly at ralcazar(at)ub.edu
 
   
 
   
'''2014'''
 
 
   
 
   
[http://www.frontiersin.org/plant_metabolism_and_chemodiversity/researchtopics/plant_polyamines_in_stress_and/1527 Frontiers topic Polyamines in Stress and Development]
 
edited by Ruben Alcazar and Antonio F. Tiburcio publishes first articles.
 
  
'''Upcoming'''  
+
''' ACADEMIC PRESS RELEASES'''<br>
 +
[http://www.ub.edu/web/ub/en/menu_eines/noticies/2015/01/020.html? Alcázar Lab work highlighted by the University of Barcelona 20.01.15]<br>
 +
[http://www.ub.edu/noticies/cgi/event.pl?id=62490&noticiaub=FARMACIA Rubén Alcázar research highlighted by the Faculty of Pharmacy at UB, January 2015]<br>
 +
[http://sefv.net/files/sd_publicaciones/58.pdf Alcázar Lab work highlighted by the Bulletin of the Spanish Society of Plant Physiology, SEFV. January, 2015]<br>
 +
[http://www.mpipz.mpg.de/4042700/PM_Parker_2015 PLoS Genet 2014 highlight by Max Planck Institute, Cologne. 11.12.14.]<br>
 +
[http://www.ub.edu/web/ub/en/menu_eines/noticies/2013/11/063.html? Arabidopsis semidwarfs: the green revolution in nature] 02.12.2013. University of Barcelona.<br>
 +
[http://www.mpipz.mpg.de/5389/news_publication_619091 Hybrid plants with over-reactive immune system] 17.11.2010. Max Planck Society.
 
   
 
   
XII Reunión de Biología Molecular de Plantas, Cartagena, 11-13 de junio de 2014.
+
<br>
<br><br>
 
 
----
 
----
[http://www.ub.edu/farmacia/ The Faculty] | [http://www.ub.edu The University] | [http://bkc.upc.ub.edu/ The Campus] | [http://www.ccit.ub.edu/EN/home.html Scientific and Technological Centers]
+
<font face="calibri" style="color:#000000" font size="2">
 +
Rubén Alcázar is Ramón y Cajal Researcher at the Department of Biology, Healthcare and Environment of the [http://www.ub.edu University of Barcelona].<br>
 +
----
 +
<br>'''Research in Alcázar Lab is supported by:'''
 +
 
 +
<font face="calibri" style="color:#000000" font size="2"><br>
 +
* 7th Framework Programme. Marie Curie Career Integration Grant (DISEASENVIRON, PCIG10-GA-2011-303568) of the European Union.  
 +
* Ramón y Cajal Program (RYC-2011-07847) of the Ministerio de Ciencia e Innovación (Spain).
 +
* BFU2013-41337-P grant of the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia (Ministerio de Economía y Competitividad, Spain).
 +
 
 
----
 
----
<br><br>
 
<font face="calibri" style="color:#000000" font size="2">
 
Full address: Facultat de Farmacia, Universitat de Barcelona, Unitat de Fisiologia Vegetal. Avda Joan XXIII 27-31, 08028 Barcelona (Spain). <br>
 
Tel +34 934 024 492 Fax +34 934 029 043 <br><br>
 
<p>This wiki site is built under [http://www.openwetware.org Openwetware],  an open access movement promoting the sharing of information among researchers.</p>
 

Latest revision as of 01:53, 11 August 2017

Alcazarlab logo.jpg

**** New lab webpage hosted at University of Barcelona servers***
Please visit: http://www.ub.edu/portal/web/dp-bsma/stress


LogoUB .jpg
Dept. Biology, Healthcare & Environment
Section of Plant Physiology
Facultat de Farmàcia, Av. Joan XXIII 27-31
08028 Barcelona, Spain

<html><a href="http://www.revolvermaps.com/?target=enlarge&i=0ewrbw4fec7"><img src="//ra.revolvermaps.com/h/m/a/0/fff600/128/40/0ewrbw4fec7.png" width="156" height="100" alt="Map" style="border:0;"></a>


Dear visitor,

Welcome to the Molecular Genetics of Plant Stress Tolerance Lab (Ruben Alcazar & A.F. Tiburcio Labs) at the Department of Biology, Healthcare & Environment of the University of Barcelona.

We're a recently created joint research group that investigates the adaptation of plants to local environments. We focus on the evolutionary adaptation of plant populations to abiotic and biotic stresses, which are major challenges for plant survival under the current climate change predictions. Derived from our research, we investigate ways for improving stress protection.

For a more detailed view of our research, please have a look at our Research Projects and Scientific Publications sections. You can follow an updated list of our activities and publications in the NEWS section below. For any other enquires, do not hesitate to contact us directly.












1. POLYAMINE PERCEPTION AND SIGNALING

Polyamines.jpg


Our research laboratory has long-standing experience in the field of plant polyamines, for which we performed a number of omics approaches and established genetic evidence for their role in abiotic stress protection.


Our previous research pointed to interactions of polyamines with hormones and other stress-related metabolites. Our current goal is to investigate how polyamines are perceived by the plant, which early signaling components are involved, and how this is shaped by the environment.


We’re making use of background knowledge from different disciplines to gain insight into polyamine perception and signaling, for which little is known in plants. We’re making use of genetics of natural variation, reverse genetics, molecular biology and plant-microbe interactions to unravel how polyamines are sensed and how this relates to the local microbiota.


Our final goal is to provide novel approaches for crop protection against abiotic and biotic stresses.


Key words: stress tolerance, drought, salinity, freezing tolerance, priming, ROS, crop protection, microbiome, rhizosphere, polyamines, natural variation, transcriptional regulation, metabolon, modulon.


2. MOLECULAR EVOLUTION OF DISEASE RESISTANCE IN PLANTS


In our lab, we make use of the extensive natural variation of Arabidopsis thaliana populations to answer key fundamental questions:

  • How plants adapt to local environments including the microbiota?
  • How plants maintain variability of genes involved in pathogen recognition and to which extent this variability is caused by the interaction with pathogens?
  • How the environment manipulates immune responses? How this affects the above points?


To address these and other questions, we (and others) developed a new model for plant immunity studies based on the use of Arabidopsis immune-related incompatible hybrids. These are hybrids obtained by crosses of natural Arabidopsis accessions that exhibit constitutive activation of defense, stunted growth and sterility in the absence of pathogen challenge. Often, such phenotypes are temperature-dependent and suppressed at high temperature.


These genetic interactions might unravel molecular partners required for proper modulation of defense. Some of these cases are background-dependent and therefore, likely difficult to be observed in classical reference accessions.


Since some years, we're using the Ler / Kas-2 immune-related hybrid incompatibility as molecular model to answer some of the questions above. The Landsberg (from Gorzów Wielkopolski, Poland)/Kashmir-2 (from Kashmir mountains) incompatibility involves populations in Central Europe and Central Asia which enable to expand our analyses to population scales. We apply population genetics on top of our molecular and biochemical analyses.


Derived from our research, we attempt to provide new strategies for crop protection at medium to long-term.






Announcement alcazar.jpg News and Announcements e-Board

 NEWS
Master in Molecular Biotechnology (Trabajo Final de Máster) offers.
info
Contact us directly at ralcazar(at)ub.edu


ACADEMIC PRESS RELEASES

Alcázar Lab work highlighted by the University of Barcelona 20.01.15
Rubén Alcázar research highlighted by the Faculty of Pharmacy at UB, January 2015
Alcázar Lab work highlighted by the Bulletin of the Spanish Society of Plant Physiology, SEFV. January, 2015
PLoS Genet 2014 highlight by Max Planck Institute, Cologne. 11.12.14.
Arabidopsis semidwarfs: the green revolution in nature 02.12.2013. University of Barcelona.
Hybrid plants with over-reactive immune system 17.11.2010. Max Planck Society.



Rubén Alcázar is Ramón y Cajal Researcher at the Department of Biology, Healthcare and Environment of the University of Barcelona.



Research in Alcázar Lab is supported by:


  • 7th Framework Programme. Marie Curie Career Integration Grant (DISEASENVIRON, PCIG10-GA-2011-303568) of the European Union.
  • Ramón y Cajal Program (RYC-2011-07847) of the Ministerio de Ciencia e Innovación (Spain).
  • BFU2013-41337-P grant of the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia (Ministerio de Economía y Competitividad, Spain).