Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic cell culture models and functional tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health.
- Daniel Lih was awarded a summer research position at National Yang-Ming University! Congratulations Daniel! (June 2013)
- D. Kim was awarded an Muscular Dystrophy Association (MDA) research grant to develop techniques for growing muscle for use in transplantation into a mouse model of Duchenne muscular dystrophy and was featured on the MDA website (Apr. 2013)
- Daniel Lih has been awarded the Mary Gates Undergraduate Research Scholarship!
- Hee Seok Yang, who was a post doc in the lab, has accepted an offer to start as a faculty member at the Dankook University in Korea. Congratulations! (Feb. 2013)
- Alex Jiao, Nicole Trosper, and Justin Lee win the Outstanding Paper Award at the 2013 ASME Global Congress on Nano Engineering for Medicine and Biology (Feb. 2013)
- D. Kim was invited to join the editorial board of the Journal of Micro-Bio Robotics as an Associate Editor (Jan. 2013)
- D. Kim joins the honorary Editorial Board of the International Journal of Nanomedicine (Jan. 2013)
- D. Kim joins the Editorial Board of the IET Nanobiotechnology Journal (Jan. 2013)
- A non-transcriptional role for HIF-1α as a direct inhibitor of DNA replication, Science Signaling, vol. 6, pp. ra10, 2013. (Featured as a Cover Article) Article Podcast
- Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 (Featured Cover Article) Article
- Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. (Featured as a Cover Article) Article
- Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. Article
- Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. Pubmed, Hubmed
- Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. Article (Highlighted in the National Institute of Biomedical Imaging and Bioengineering)
- Microengineered platforms for cell mechanobiology, Annual Review of Biomedical Engineering, vol. 11, pp.203-233, 2009. Article