Our research spans the disciplinary boundaries between nanobiotechnology, biomaterials, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic materials/devices/systems and functional tissue engineering models for elucidatig cell biology, stem cell-based therapies, disease modeling, and high-throughput drug screening. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell/tissue function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health.
- The Kim lab has been awarded the [https://www.wnf.washington.edu/ WRF Microfabrication Commercialization Grant. This award will support our work on development of a next generation integrated MEA-nanodevice for drug-induced cardiotoxicity screening. (Nov. 2013)
- Cameron Nemeth has been given a BMES Undergraduate Design and Research Award for his extended abstract for BMES 2013. Cameron also received the Washington Research Foundation Fellowship. Congratulations Cameron! (Sept. 2013)
- Alex Jiao was awarded a NIH T32 Cardiovascular Pathology Training Grant Fellowship. (Aug. 2013).
- Prof. Kim has been awarded the prestigious Young Investigator Award 2013 from the Korean-American Scientists and Engineers Association (KSEA). (June 2013)
- Jesse Macadangdang was awarded a NIH Bioengineering Cardiovascular Training Grant Fellowship! (June 2013)
- Daniel Lih was awarded a summer research fellowship from National Yang-Ming University! (June 2013)
- Prof. Kim joined the editorial board of the Journal of Biomedical Nanotechnology as an Associate Editor. (May 2013)
- Kim Lab has been awarded an Muscular Dystrophy Association (MDA) research grant to develop bioengineering techniques for growing muscle for use in transplantation into a mouse model of Duchenne muscular dystrophy. (Feb. 2013)
- A non-transcriptional role for HIF-1α as a direct inhibitor of DNA replication, Science Signaling, vol. 6, pp. ra10, 2013. (Featured as a Cover Article) Article Podcast
- Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 (Featured Cover Article) Article
- Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. (Featured as a Cover Article) Article
- Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. Article
- Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. Pubmed, Hubmed
- Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. Article (Highlighted in the National Institute of Biomedical Imaging and Bioengineering)
- Microengineered platforms for cell mechanobiology, Annual Review of Biomedical Engineering, vol. 11, pp.203-233, 2009. Article