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[[Kim:News | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''NEWS''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:News | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''NEWS''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Links | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''LINKS''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Links | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''LINKS''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Contact | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''CONTACT''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Outreach | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''OUTREACH''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[[Kim:Contact | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''CONTACT''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Outreach | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''OUTREACH''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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<h3>Overview</h3>
<h3>Overview</h3>
<font size=3>Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic cell culture models and functional tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health. </font>
<font size=3>Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic materials/devices/systems and functional tissue engineering models for high-throughput drug screening, stem cell-based therapies, disease modeling, and medical device development. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health. </font>
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<h3>News</h3>  
<h3>News</h3>  
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<font size=3>
* Our recent Integrative Biology cover article is featured on the [http://blogs.rsc.org/ib/2012/08/22/mimicking-heart-tissue-and-understanding-the-spatial-development-of-neurons-on-the-cover-of-issue-9/ Integrative Biology blog]. (Aug. 2012)
* Cameron Nemeth has been given a BMES Undergraduate Design and Research Award for his extended abstract for BMES 2013.  Congratulations Cameron!
* D. Kim was invited to join the editorial board of the [http://www.springer.com/engineering/electronics/journal/12213 Journal of Micro-Bio Robotics] as an Associate Editor (Jan. 2013)
* Kim Lab has been awarded an [http://mda.org/research/gaag/dmd-deok-ho-kim-phd Muscular Dystrophy Association (MDA) research grant] to develop bioengineering techniques for growing muscle for use in transplantation into a mouse model of Duchenne muscular dystrophy. (Feb. 2013)
* D. Kim joins the honorary Editorial Board of the [http://www.dovepress.com/honorary-editorial-board-international-journal-of-nanomedicine-edboard5 International Journal of Nanomedicine] (Jan. 2013)
* Hee Seok Yang, who was a post doc in the lab, has accepted an offer to start as a faculty member at the Dankook University in Korea. Congratulations! (Feb. 2013)
* D. Kim joins the Editorial Board of the [http://digital-library.theiet.org/content/journals/iet-nbt IET Nanobiotechnology Journal]  (Jan. 2013)
* Alex Jiao win the Outstanding Paper Award at the 2013 ASME Global Congress on Nano Engineering for Medicine and Biology (Feb. 2013)
* Alex Jiao is selected for a travel award and a short talk speaker for the [http://www.sprbm.org/ BMES 2013 Cellular and Molecular Bioengineering Conference] (Jan.2013)
* Prof. Kim was invited to join the editorial board of the [http://www.springer.com/engineering/electronics/journal/12213 Journal of Micro-Bio Robotics] as an Associate Editor (Jan. 2013)
* D. Kim received the [http://bmes.org/index.asp BMES-CMBE] "Rising Star" award (Jan. 2013)
* Prof. Kim joins the honorary Editorial Board of the [http://www.dovepress.com/honorary-editorial-board-international-journal-of-nanomedicine-edboard5 International Journal of Nanomedicine] (Jan. 2013)
* Prof. Kim joins the Editorial Board of the [http://digital-library.theiet.org/content/journals/iet-nbt IET Nanobiotechnology Journal]  (Jan. 2013)  




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<h3>Featured Publications</h3>  
<h3>Featured Publications</h3>  
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* A non-transcriptional role for HIF-1α as a direct inhibitor of DNA replication, Science Signaling, vol. 6, pp. ra10, 2013. [http://stke.sciencemag.org/content/vol6/issue262/cover.dtl '''(Featured as a Cover Article)''']  [http://stke.sciencemag.org/cgi/content/full/sigtrans;6/262/ra10 Article] [http://stke.sciencemag.org/cgi/content/full/sigtrans;6/262/pc5/DC1 Podcast]<br>
* Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 [http://pubs.rsc.org/en/journals/journalissues/ib#!issueid=ib004009&type=current&issnprint=1757-9694 '''(Featured Cover Article)''']    [http://pubs.rsc.org/en/content/articlelanding/2012/ib/c2ib20067h Article]<br>
* Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 [http://pubs.rsc.org/en/journals/journalissues/ib#!issueid=ib004009&type=current&issnprint=1757-9694 '''(Featured Cover Article)''']    [http://pubs.rsc.org/en/content/articlelanding/2012/ib/c2ib20067h Article]<br>
* Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. [http://stke.sciencemag.org/content/vol5/issue227/cover.dtl '''(Featured as a Cover Article)''']  [http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/227/ra41 Article]
* Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. [http://stke.sciencemag.org/content/vol5/issue227/cover.dtl '''(Featured as a Cover Article)''']  [http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/227/ra41 Article]
* Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. [http://www.pnas.org/content/early/2011/03/03/1011258108.full.pdf+html Article]<BR>
* Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. [http://www.pnas.org/content/early/2011/03/03/1011258108.full.pdf+html Article]<BR>
* Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20803528 Pubmed], [http://www.hubmed.org/display.cgi?uids=20803528 Hubmed] <BR>
* Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20803528 Pubmed], [http://www.hubmed.org/display.cgi?uids=20803528 Hubmed] <BR>
* Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20018748 Pubmed], [http://www.hubmed.org/display.cgi?uids=20018748 Hubmed] <BR>
* Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20018748 Article] [http://www.nibib.nih.gov/HealthEdu/eAdvances/30July10 '''(Highlighted in the National Institute of Biomedical Imaging and Bioengineering)]'''
* Microengineered platforms for cell mechanobiology, Annual Review of Biomedical Engineering, vol. 11, pp.203-233, 2009. [http://www.ncbi.nlm.nih.gov/pubmed/19400708 Article]
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<font size = 3> '''Our sponsors''': <br>
[[Image: AHA.jpg|150px]] &emsp;&emsp;
[[Image: MDAlogo name.jpg|220px|link=http://mda.org/]] &emsp;&emsp;
[[Image: Coulter.jpg|110px]]  &emsp;&emsp;
[[Image: C4C.png|190px]] &emsp;&emsp;&emsp;&emsp; 
[http://www2.clustrmaps.com/user/a76c219e http://www2.clustrmaps.com/stats/maps-no_clusters/www.openwetware.org-wiki-Kim-thumb.jpg]
[http://www2.clustrmaps.com/user/a76c219e http://www2.clustrmaps.com/stats/maps-no_clusters/www.openwetware.org-wiki-Kim-thumb.jpg]


Revision as of 19:29, 29 July 2013

HOME        RESEARCH        PEOPLE        PUBLICATIONS        INTERNAL        POSITIONS        NEWS        LINKS        OUTREACH        CONTACT       

Overview

Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic materials/devices/systems and functional tissue engineering models for high-throughput drug screening, stem cell-based therapies, disease modeling, and medical device development. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health.

News

  • Cameron Nemeth has been given a BMES Undergraduate Design and Research Award for his extended abstract for BMES 2013. Congratulations Cameron!
  • Kim Lab has been awarded an Muscular Dystrophy Association (MDA) research grant to develop bioengineering techniques for growing muscle for use in transplantation into a mouse model of Duchenne muscular dystrophy. (Feb. 2013)
  • Hee Seok Yang, who was a post doc in the lab, has accepted an offer to start as a faculty member at the Dankook University in Korea. Congratulations! (Feb. 2013)
  • Alex Jiao win the Outstanding Paper Award at the 2013 ASME Global Congress on Nano Engineering for Medicine and Biology (Feb. 2013)
  • Prof. Kim was invited to join the editorial board of the Journal of Micro-Bio Robotics as an Associate Editor (Jan. 2013)
  • Prof. Kim joins the honorary Editorial Board of the International Journal of Nanomedicine (Jan. 2013)
  • Prof. Kim joins the Editorial Board of the IET Nanobiotechnology Journal (Jan. 2013)


Featured Publications

  • A non-transcriptional role for HIF-1α as a direct inhibitor of DNA replication, Science Signaling, vol. 6, pp. ra10, 2013. (Featured as a Cover Article) Article Podcast
  • Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 (Featured Cover Article) Article
  • Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. (Featured as a Cover Article) Article
  • Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. Article
  • Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. Pubmed, Hubmed
  • Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. Article (Highlighted in the National Institute of Biomedical Imaging and Bioengineering)
  • Microengineered platforms for cell mechanobiology, Annual Review of Biomedical Engineering, vol. 11, pp.203-233, 2009. Article


Our sponsors:
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