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[[Kim:Links | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''LINKS''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Links | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''LINKS''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Contact | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''CONTACT''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Contact | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''CONTACT''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Kim:Outreach | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''OUTREACH''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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<h3>Overview</h3>
<h3>Overview</h3>
<font size=6>Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale fabrication and integration tools, we focus on the development and applications of biomimetic cell culture models and functional tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health. </font>
<font size=3>Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic cell culture models and functional tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health. </font>
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<h3>News</h3>  
<h3>News</h3>  
* 5/2011  Derek received a NASA Summer Undergraduate Research Fellowship
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* 5/2011  Prof. Kim has been selected as the 2011 recipient of the [http://www.washington.edu/news/articles/perkins-coie-awards-grant-for-nanoengineering-patch-to-repair-heart-attack-damage '''Perkins Coie Award for Discovery''']  
* Cameron Nemeth received The SLUG Symposium Undergraduate Student Award (2012)
* 4/2011   Alex was awarded a NIH Bioengineering Cardiovascular Training Fellow
* Derek Britain, Sam Frankel, Cameron Nemeth, and Nicole Trosper have been awarded for Mary Gates Undergraduate Research Scholarship (2012)
* 7/2010  Prof. Kim featured in [http://www.nibib.nih.gov/HealthEdu/eAdvances/30July10 '''National Institute of Biomedical Imaging and Bioengineering'''] article on a nanoengineered patch for the damaged heart
* D. Kim appointed as program committee member of [http://www.ieee-nanomed.org/2012/ '''IEEE International Conference on Nano/Molecular Medicine and Engineering''']  (2012)
* 5/2010  Prof. Kim received the [http://www.fhcrc.org/about/ne/news/2010/03/08/weintraub.html '''Harold M. Weintraub Award''']
* D. Kim co-organized the first USACM Thematic Conference on Multiscale Methods and Validation in Medicine and Biology: Biomechanics and Mechanobiology (Jan, 2012)
* 12/2009  PNAS paper discussed in [http://www.sciencedaily.com/releases/2009/12/091215153632.html '''Science Daily'''] magazine
* D. Kim gave an invited talk at the 5th International Conference on Cell Therapy, Seoul, Korea (Nov. 2011)
* 5/2009  [http://onlinelibrary.wiley.com/doi/10.1002/adfm.200990041/abstract '''Advanced Functional Materials'''] paper featured as Frontispiece
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<h3>Recent Publications</h3>  
<h3>Featured Publications</h3>
* D.H. Kim, H.J. Lee, Y.K. Lee, J.M. Nam, and A. Levchenko, "'''Biomimetic nanopatterns as enabling tools for analysis and control of live cells,'''" Advanced Materials, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20803528 Pubmed], [http://www.hubmed.org/display.cgi?uids=20803528 Hubmed] <BR>
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* D.H. Kim, E. Lipke, P. Kim, R. Cheong, S. Edmonds, M. Delannoy, K.Y. Suh, L.Tung, and A. Levchenko, "'''Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs'''," Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20018748 Pubmed], [http://www.hubmed.org/display.cgi?uids=20018748 Hubmed] <BR>
* Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 [http://pubs.rsc.org/en/journals/journalissues/ib#!issueid=ib004009&type=current&issnprint=1757-9694 '''(Featured Cover Article)''']    [http://pubs.rsc.org/en/content/articlelanding/2012/ib/c2ib20067h Article]<br>
* D.H. Kim, P. Wong, J.Y. Park, A. Levchenko, and Y. Sun, "'''Microengineered platform for cell mechanobiology'''," Annual Review of Biomedical Engineering, vol. 11, pp.203-233, 2009. [http://www.ncbi.nlm.nih.gov/pubmed/19400708 Pubmed] <BR>
* Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. [http://stke.sciencemag.org/content/vol5/issue227/cover.dtl '''(Featured as a Cover Article)''']  [http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/227/ra41 Article]
 
* Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. [http://www.pnas.org/content/early/2011/03/03/1011258108.full.pdf+html Article]<BR>
* Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20803528 Pubmed], [http://www.hubmed.org/display.cgi?uids=20803528 Hubmed] <BR>
* Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20018748 Pubmed], [http://www.hubmed.org/display.cgi?uids=20018748 Hubmed] <BR>
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Revision as of 21:24, 18 December 2012

HOME        RESEARCH        PEOPLE        PUBLICATIONS        INTERNAL        POSITIONS        NEWS        LINKS        CONTACT        OUTREACH       

Overview

Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic cell culture models and functional tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health.

News

  • Cameron Nemeth received The SLUG Symposium Undergraduate Student Award (2012)
  • Derek Britain, Sam Frankel, Cameron Nemeth, and Nicole Trosper have been awarded for Mary Gates Undergraduate Research Scholarship (2012)
  • D. Kim appointed as program committee member of IEEE International Conference on Nano/Molecular Medicine and Engineering (2012)
  • D. Kim co-organized the first USACM Thematic Conference on Multiscale Methods and Validation in Medicine and Biology: Biomechanics and Mechanobiology (Jan, 2012)
  • D. Kim gave an invited talk at the 5th International Conference on Cell Therapy, Seoul, Korea (Nov. 2011)

Featured Publications

  • Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 (Featured Cover Article) Article
  • Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. (Featured as a Cover Article) Article
  • Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. Article
  • Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. Pubmed, Hubmed
  • Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. Pubmed, Hubmed

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