|The Liu Lab||Department of Craniofacial Biology||Kings College London|
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Welcome to the Liu lab!
We are interested in signal transduction in developmental biology.
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
Recent updates to the lab wiki
19 January 2018
|N 14:53||Get reimbursed for Travel (diff | hist) . . (+49) . . Reicker1 (Created page with "This is a second test because nothing is working.")|
|N 14:18||Get reimbursed fo Travel (diff | hist) . . (+52) . . Reicker1 (Created page with "This is a test because I can't seem to save my page.")|
|N 14:09||Send my research materials to someone at another research institution? (diff | hist) . . (+2,187) . . Reicker1 (Created page with "'''How to: get reimbursed for travel and conferences?''' First and foremost:''' You must book your travel with an airline from the ''Fly America Act'' list. Stanford does n...")|
(cur | prev) . . (+2,266) . . Reicker1 (Created page with "'''Getting reimbursed for travel and conferences''' '''First and foremost: You must book your travel with an airline from the Fly America Act list.''' Stanford does not rei...")
|13:12||10K Genes/Project Documentation (diff | hist) . . (+149) . . Koeng|
|13:01||10K Genes/Collections (diff | hist) . . (+108) . . Koeng (→Official hashtag list)|
|13:00||Beauchamp:Orientation (diff | hist) . . (+139) . . Michael S Beauchamp|
|12:42||Endy Lab (diff | hist) . . (+171) . . Reicker1 (→News)|
|12:12||User:Korey Griffin (diff | hist) . . (+27) . . Korey Griffin (→Contact)|
|11:21||Moneil5 Dahlquist Lab Notebook (diff | hist) . . (+445) . . Margaret J. Oneil (→Spring 2018: updated 1.19.18 lab meeting)|
|11:19||User:Lauren M. Kelly (diff | hist) . . (+82) . . Lauren M. Kelly (→Upper Division Courses in Biology, Chemistry, Math, and Computer Science)|
|11:17||Lkelly Spring 2018 Notebook (diff | hist) . . (+77) . . Lauren M. Kelly (added pages for months)|
|10:47||BioMicroCenter:BIG meeting (diff | hist) . . (+139) . . George W Bell (→2017-2018 academic year)|
|09:44||Chenlab (diff | hist) . . (0) . . Kaifu Chen|
|09:44||HughesLab:LabMembers (diff | hist) . . (+2) . . Michael E Hughes|
18 January 2018
|18:16||BME100 s2018:Group6 W0800 L1 (diff | hist) . . (+6) . . Dadesimo (→OUR TEAM)|
|m 14:59||Endy Lab (diff | hist) . . (0) . . Reicker1 (→News)|
|14:46||HughesLab:Publications (diff | hist) . . (+195) . . Scott A. Lewis (→Publications)|
|14:19||(Upload log) . . Scott A. Lewis uploaded File:ExpressionDB Fig1.png |
|14:11||User:Scott A. Lewis (diff | hist) . . (+9) . . Scott A. Lewis|
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