Karenliu

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The Liu Lab Department of Craniofacial Biology Kings College London
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Welcome to the Liu lab!

We are interested in signal transduction in developmental biology.


In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists.


The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.

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Recent updates to the lab wiki

23 October 2017

     09:50  Tomlinson:Lab Members‎ (diff | hist) . . (+9). . Ryan E. Tomlinson (talk | contribs)
     09:06  BME100 f2017:Group12 W0800 L4‎ (diff | hist) . . (+893). . Vishnu Karthigeyan (talk | contribs) (Protocol)
     06:48  Template:Banta Lab Side‎ (diff | hist) . . (+192). . Scott Banta (talk | contribs) (Recent Lab News)
     05:37  Rich Lab:Funding‎ (diff | hist) . . (-53). . Isabel C. Morales (talk | contribs)
     03:52  User:Maureen McKeague‎ (diff | hist) . . (+135). . Maureen McKeague (talk | contribs) (Publications)

22 October 2017

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BME100 f2017:Group10 W1030 L4‎‎ (5 changes | history) . . (+287). . [Adrienne L. Parkinson‎ (5×)]

     

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BME100 f2017:Group12 W0800 L4‎‎ (9 changes | history) . . (+1,527). . [Vishnu Karthigeyan‎; Kira L. Stryker‎; Amy Nystrom‎; Priscilla Y. Han‎ (2×); Jason Zhang‎ (4×)]

     

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[Vishnu Karthigeyan‎; Priscilla Y. Han‎; Jason Zhang‎; Adrienne L. Parkinson‎]

     

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. . Priscilla Y. Han (talk | contribs) uploaded File:Doomsducks.jpg

     

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. . Adrienne L. Parkinson (talk | contribs) uploaded File:BME100G10 PCR.jpg

     

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. . Jason Zhang (talk | contribs) uploaded File:PCR SS.png

     

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. . Vishnu Karthigeyan (talk | contribs) uploaded File:Rottweiler Vishnu.jpg

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BME100 f2017:Group13 W1030 L4‎‎ (7 changes | history) . . (+950). . [Daniel Beltran Salas‎ (7×)]

     

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Biomod/2017/StJohns:Protocols‎‎ (7 changes | history) . . (-669). . [Alexkk15‎ (7×)]

     

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(cur | prev) . . (+6). . Alexkk15 (talk | contribs) (Polarization Measurements)

     

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(cur | prev) . . (+6). . Alexkk15 (talk | contribs) (Taking Emission Spectra)

     

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Biomod/2017/StJohns:Results‎‎ (9 changes | history) . . (+1,896). . [Alexkk15‎ (9×)]

     

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     19:13 (User creation log) . . User account Peter (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎
     18:59  Biomod/2017/StJohns‎ (diff | hist) . . (+291). . Alexkk15 (talk | contribs)
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