Difference between revisions of "Karenliu"

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Welcome to the Liu Lab!
==Welcome to the Liu lab!==
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We are interested in signal transduction in developmental biology.
 
We are interested in signal transduction in developmental biology.
  
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
 
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
  

Latest revision as of 06:00, 27 August 2013

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links


Welcome to the Liu Lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


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Recent updates to the lab wiki

19 June 2018

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Yeo lab:Reprints‎‎ (5 changes | history) . . (+251). . [Yoonyeo‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (+9). . Yoonyeo (talk | contribs) (Peer-reviewed articles)

     

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(cur | prev) . . (+8). . Yoonyeo (talk | contribs) (Peer-reviewed articles)

     

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(cur | prev) . . (+4). . Yoonyeo (talk | contribs) (Peer-reviewed articles)

     

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(User creation log). .

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. . User account Delangeo (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

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     13:43  Yeo lab:news archive‎ (diff | hist) . . (+209). . Yoonyeo (talk | contribs)

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Yeo lab‎‎ (3 changes | history) . . (+5). . [Yoonyeo‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (-209). . Yoonyeo (talk | contribs) (News)

     

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(cur | prev) . . (+215). . Yoonyeo (talk | contribs) (News)

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Taylor:Publications‎‎ (4 changes | history) . . (+1,806). . [Lynne S. Taylor‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (+917). . Lynne S. Taylor (talk | contribs) (PUBLICATIONS)

     

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(cur | prev) . . (+416). . Lynne S. Taylor (talk | contribs) (PUBLICATIONS)

     

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(cur | prev) . . (+22). . Lynne S. Taylor (talk | contribs) (PUBLICATIONS)

     

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(cur | prev) . . (+451). . Lynne S. Taylor (talk | contribs) (PUBLICATIONS)

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HughesLab:LabMembers‎‎ (4 changes | history) . . (-30). . [Scott A. Lewis‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (+23). . Scott A. Lewis (talk | contribs) (Lab Alumni)

     

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(cur | prev) . . (-35). . Scott A. Lewis (talk | contribs) (Lab Alumni)

     

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(cur | prev) . . (+189). . Scott A. Lewis (talk | contribs) (Lab Alumni)

     

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OpenSourceTB:Story so far‎‎ (2 changes | history) . . (-5,988). . [Matthew Todd‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (-5,477). . Matthew Todd (talk | contribs) (General Background to TB)

18 June 2018

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Hoatlin:BMB seminar series 2017-2018‎‎ (3 changes | history) . . (+51). . [Maureen E. Hoatlin‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (-2). . Maureen E. Hoatlin (talk | contribs) (Seminar Series Planning 2018-2019)

     

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(cur | prev) . . (+3). . Maureen E. Hoatlin (talk | contribs) (Seminar Series Planning 2018-2019)

     

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(cur | prev) . . (+50). . Maureen E. Hoatlin (talk | contribs) (Seminar Series Planning 2018-2019)

     09:05  McClean:LabMtgSchedule‎ (diff | hist) . . (+518). . Megan N McClean (talk | contribs)
     05:36  Lauffenburger:Brian Joughin‎ (diff | hist) . . (+55). . Bjoughin (talk | contribs) (Publications)

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User:Etienne Robillard/Notebook/Research‎‎ (4 changes | history) . . (+976). . [Etienne Robillard‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (+208). . Etienne Robillard (talk | contribs)

     

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(cur | prev) . . (+719). . Etienne Robillard (talk | contribs) (sync page with master server)

     

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(cur | prev) . . (+26). . Etienne Robillard (talk | contribs) (minor update)

     

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 m   01:49  Forster Lab‎ (diff | hist) . . (+186). . Anthony C. Forster (talk | contribs) (new publications)
     00:44  Pecreaux‎ (diff | hist) . . (+7). . Jacques Pecreaux (talk | contribs)

17 June 2018

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Pecreaux‎‎ (2 changes | history) . . (+115). . [Jacques Pecreaux‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (+45). . Jacques Pecreaux (talk | contribs) (News!)

     

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(cur | prev) . . (+70). . Jacques Pecreaux (talk | contribs) (News!)

     23:31 

(Upload log). .

[Jacques Pecreaux‎ (⧼ntimes⧽)]

     

23:31

. . Jacques Pecreaux (talk | contribs) uploaded File:Master LC 2018-2019 dynamique-mécanique-fuseau+.pdf

     

23:25

. . Jacques Pecreaux (talk | contribs) uploaded File:Stage microtubules CeDRE master2018-2019 FR.pdf

     18:38  OpenSourceTB‎ (diff | hist) . . (-905). . Matthew Todd (talk | contribs)
     18:03  OpenSourceTB:Compound Series‎ (diff | hist) . . (+94). . Matthew Todd (talk | contribs)

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OpenSourceTB:OSTB Series 1‎‎ (6 changes | history) . . (-2,153). . [Matthew Todd‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (-209). . Matthew Todd (talk | contribs) (Data for this Page)

     

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(cur | prev) . . (-231). . Matthew Todd (talk | contribs) (Preliminary Work on the Series Outside GSK)

     

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(cur | prev) . . (-87). . Matthew Todd (talk | contribs) (Other Sources of These, or Similar, Compounds)

     

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(cur | prev) . . (-461). . Matthew Todd (talk | contribs) (Project 3)

     

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(cur | prev) . . (-730). . Matthew Todd (talk | contribs) (Project 1)

     

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(cur | prev) . . (-435). . Matthew Todd (talk | contribs) (Project 2)

15 June 2018

     16:52  User:Gareth Trubl‎ (diff | hist) . . (+66). . Gtrubl (talk | contribs)

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The Essential Unknowns/Set Theories‎‎ (2 changes | history) . . (+60). . [Koeng‎ (⧼ntimes⧽)]

     

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