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==Welcome to the Liu lab!==
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Welcome to the Liu Lab!
 
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We are interested in signal transduction in developmental biology.
 
We are interested in signal transduction in developmental biology.
  
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 
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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
  
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
 
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Latest revision as of 06:00, 27 August 2013

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links


Welcome to the Liu Lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


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Recent updates to the lab wiki

22 October 2017

     22:20 

BME100 f2017:Group10 W1030 L4‎‎ (5 changes | history) . . (+287). . [Adrienne L. Parkinson‎ (5×)]

     

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(cur | prev) . . (+147). . Adrienne L. Parkinson (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+166). . Adrienne L. Parkinson (talk | contribs) (Research and Development)

     

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BME100 f2017:Group12 W0800 L4‎‎ (10 changes | history) . . (+1,920). . [Vishnu Karthigeyan‎; Kira L. Stryker‎; Priscilla Y. Han‎ (2×); Amy Nystrom‎ (2×); Jason Zhang‎ (4×)]

     

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(cur | prev) . . (+5). . Priscilla Y. Han (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (-5). . Priscilla Y. Han (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (+884). . Kira L. Stryker (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+609). . Amy Nystrom (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+4). . Vishnu Karthigeyan (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (+393). . Amy Nystrom (talk | contribs) (SNP Information & Primer Design)

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(Upload log). .

[Vishnu Karthigeyan‎; Priscilla Y. Han‎; Adrienne L. Parkinson‎; Jason Zhang‎ (3×)]

     

22:01

. . Priscilla Y. Han (talk | contribs) uploaded File:Doomsducks.jpg

     

21:59

. . Adrienne L. Parkinson (talk | contribs) uploaded File:BME100G10 PCR.jpg

     

18:55

. . Jason Zhang (talk | contribs) uploaded File:PCR SS.png

     

18:53

. . Vishnu Karthigeyan (talk | contribs) uploaded File:Rottweiler Vishnu.jpg

     

18:49

. . Jason Zhang (talk | contribs) uploaded a new version of File:IMG 3271.jpeg

     

18:49

. . Jason Zhang (talk | contribs) uploaded a new version of File:IMG 3271.jpeg

     21:53 

BME100 f2017:Group13 W1030 L4‎‎ (7 changes | history) . . (+950). . [Daniel Beltran Salas‎ (7×)]

     

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(cur | prev) . . (-2). . Daniel Beltran Salas (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+409). . Daniel Beltran Salas (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+16). . Daniel Beltran Salas (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+609). . Daniel Beltran Salas (talk | contribs) (Protocol)

     

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(cur | prev) . . (+8). . Daniel Beltran Salas (talk | contribs) (Protocol)

     

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(cur | prev) . . (-25). . Daniel Beltran Salas (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (-65). . Daniel Beltran Salas (talk | contribs) (OUR TEAM)

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Biomod/2017/StJohns:Protocols‎‎ (7 changes | history) . . (-669). . [Alexkk15‎ (7×)]

     

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(cur | prev) . . (+6). . Alexkk15 (talk | contribs) (Polarization Measurements)

     

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(cur | prev) . . (+6). . Alexkk15 (talk | contribs) (Taking Emission Spectra)

     

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(cur | prev) . . (-755). . Alexkk15 (talk | contribs) (XXXPolarization MeasurementsXXX)

     

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(cur | prev) . . (-6). . Alexkk15 (talk | contribs) (XXXTaking Emission SpectraXXX)

     

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(cur | prev) . . (+109). . Alexkk15 (talk | contribs) (XXXTaking Emission SpectraXXX)

     

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(cur | prev) . . (-2,984). . Alexkk15 (talk | contribs) (Making Fab Fragments)

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Biomod/2017/StJohns:Results‎‎ (9 changes | history) . . (+1,896). . [Alexkk15‎ (9×)]

     

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(cur | prev) . . (+3). . Alexkk15 (talk | contribs)

     

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(cur | prev) . . (+6). . Alexkk15 (talk | contribs)

     

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(cur | prev) . . (-5). . Alexkk15 (talk | contribs) (1% Agarose gel; 650 Vhrs)

     

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Biomod/2015/StJohns:Video‎‎ (2 changes | history) . . (-2). . [Alexkk15‎ (2×)]

     

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(cur | prev) . . (+15). . Alexkk15 (talk | contribs) (BioMod Toehold Conga Nanny 2015)

     

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(cur | prev) . . (-17). . Alexkk15 (talk | contribs) (BioMod Toehold Conga Nanny 2015)

     19:13 (User creation log) . . User account Peter (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎
     18:59  Biomod/2017/StJohns‎ (diff | hist) . . (+291). . Alexkk15 (talk | contribs)
     18:51  User:Vishnu Karthigeyan‎ (diff | hist) . . (+7). . Vishnu Karthigeyan (talk | contribs) (Contact Info)
     18:49  BME100 f2017:Group16 W1030 L4‎ (diff | hist) . . (+1,931). . Hannah Correa (talk | contribs)
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