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==Welcome to the Liu lab!==
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Welcome to the Liu Lab!
 
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We are interested in signal transduction in developmental biology.
 
We are interested in signal transduction in developmental biology.
  
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 
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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
  
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
 
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Latest revision as of 06:00, 27 August 2013

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links


Welcome to the Liu Lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


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Recent updates to the lab wiki

18 October 2017

     15:56 

BME100 f2017:Group8 W1030 L4‎‎ (2 changes | history) . . (+426). . [Jennifer L. Brodsky‎; Jacob Tomas Harrison Haye‎]

     

15:56

(cur | prev) . . (+409). . Jennifer L. Brodsky (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+17). . Jacob Tomas Harrison Haye (talk | contribs) (SNP Information & Primer Design)

     15:20  BME100 f2017:Group7 W0800 L4‎ (diff | hist) . . (-4). . Miguel R. Almanza Lopez (talk | contribs) (OUR TEAM)

     15:16 

(Upload log). .

[Miguel R. Almanza Lopez‎; Emily A. Hanzlick‎; Teleah Hancer‎ (2×); Kaifu Chen‎ (2×); Jacob Tomas Harrison Haye‎ (4×); Alivia Ankrum‎ (8×)]

     

15:16

. . Miguel R. Almanza Lopez (talk | contribs) uploaded File:MralPoopy.jpg

     

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. . Kaifu Chen (talk | contribs) uploaded File:Jcm.jpg

     

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. . Kaifu Chen (talk | contribs) uploaded File:Wgy.jpg

     

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. . Jacob Tomas Harrison Haye (talk | contribs) uploaded a new version of File:DNA4.jpg

     

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. . Jacob Tomas Harrison Haye (talk | contribs) uploaded a new version of File:DNA4.jpg

     

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. . Jacob Tomas Harrison Haye (talk | contribs) uploaded a new version of File:DNA3.jpg

     

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. . Jacob Tomas Harrison Haye (talk | contribs) uploaded File:DNA4.jpg

     

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. . Alivia Ankrum (talk | contribs) uploaded File:Badg12.png

     

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. . Alivia Ankrum (talk | contribs) uploaded a new version of File:Goodresultsg12.png

     

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. . Alivia Ankrum (talk | contribs) uploaded File:Goodresultsg12.png

     

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. . Alivia Ankrum (talk | contribs) uploaded a new version of File:Screenshot1.png

     

13:43

. . Alivia Ankrum (talk | contribs) uploaded a new version of File:Screen Shot 2017-10-18 at 1.26.01 PM.png

     

13:41

. . Alivia Ankrum (talk | contribs) uploaded a new version of File:Screen Shot 2017-10-18 at 1.26.01 PM.png

     

13:41

. . Alivia Ankrum (talk | contribs) uploaded a new version of File:Screen Shot 2017-10-18 at 1.26.01 PM.png

     

13:39

. . Alivia Ankrum (talk | contribs) uploaded File:Screen Shot 2017-10-18 at 1.26.01 PM.png

     

13:28

. . Emily A. Hanzlick (talk | contribs) uploaded File:PolymearseChainReactionExtraCreditImageEAH.png

     

13:25

. . Teleah Hancer (talk | contribs) uploaded a new version of File:Teleah6.png

     

13:24

. . Teleah Hancer (talk | contribs) uploaded File:Teleah6.png

     14:40 

BME100 f2017:Group1 W1030 L4‎‎ (17 changes | history) . . (+1,361). . [Abby E. Krell‎ (7×); Emily A. Hanzlick‎ (10×)]

     

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(cur | prev) . . (+33). . Abby E. Krell (talk | contribs) (Protocol)

     

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(cur | prev) . . (+28). . Abby E. Krell (talk | contribs) (Protocol)

     

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(cur | prev) . . (+220). . Abby E. Krell (talk | contribs) (Protocol)

     

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(cur | prev) . . (+178). . Abby E. Krell (talk | contribs) (Protocol)

     

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(cur | prev) . . (+4). . Abby E. Krell (talk | contribs) (Research and Development)

     

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(cur | prev) . . (0). . Abby E. Krell (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+17). . Abby E. Krell (talk | contribs) (Protocol)

     

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(cur | prev) . . (+23). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (-12). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+5). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+177). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+427). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+153). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+63). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (0). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+6). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+39). . Emily A. Hanzlick (talk | contribs) (Research and Development)

     14:19 

BME100 f2017:Group12 W1030 L4‎‎ (8 changes | history) . . (+713). . [Alivia Ankrum‎ (8×)]

     

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(cur | prev) . . (0). . Alivia Ankrum (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+30). . Alivia Ankrum (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (0). . Alivia Ankrum (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+38). . Alivia Ankrum (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+30). . Alivia Ankrum (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+53). . Alivia Ankrum (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+8). . Alivia Ankrum (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+554). . Alivia Ankrum (talk | contribs) (SNP Information & Primer Design)

     13:57 

BME100 f2017:Group11 W1030 L4‎‎ (4 changes | history) . . (-98). . [Teleah Hancer‎; Zoe Marmitt‎ (3×)]

     

13:57

(cur | prev) . . (-1). . Zoe Marmitt (talk | contribs) (Protocol)

     

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(cur | prev) . . (+2). . Zoe Marmitt (talk | contribs) (Protocol)

     

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(cur | prev) . . (-108). . Zoe Marmitt (talk | contribs) (Protocol)

     

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(cur | prev) . . (+9). . Teleah Hancer (talk | contribs) (OUR TEAM)

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