Difference between revisions of "Karenliu"

From OpenWetWare
Jump to: navigation, search
 
(40 intermediate revisions by the same user not shown)
Line 1: Line 1:
 
{{Template:KarenLiu}}
 
{{Template:KarenLiu}}
 +
<br>
 +
<center>
 +
<div style="text-align: left; width: 960px; color: #183F87; font-size: 19px">
 +
Welcome to the Liu Lab!
 +
</div>
  
<div style="padding: 10px; text-align:justify; width: 830px; border: 0.5px solid #000000;">
+
<div style="text-align:left; width: 960px;">
 
 
==Welcome to the Liu lab!==
 
 
 
 
 
 
 
 
We are interested in signal transduction in developmental biology.
 
We are interested in signal transduction in developmental biology.
  
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 +
</div>
 +
<br>
 +
<div style="width: 960px; height: 124px; overflow: hidden">
 +
[[Image:KarenLiuBanner2.jpg|960px|banner]]<br>
 +
</div>
 +
<br>
  
 
+
<div style="text-align:left; width: 960px;">
 
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
 
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
  
Line 24: Line 30:
  
 
</div>
 
</div>
 +
</center>

Latest revision as of 06:00, 27 August 2013

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links


Welcome to the Liu Lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


banner


The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


<wikionly>

Recent updates to the lab wiki

20 April 2018

     03:21 

Park Lab :Publications‎‎ (2 changes | history) . . (+442). . [Jeewoong Lee‎ (2×)]

     

03:21

(cur | prev) . . (+9). . Jeewoong Lee (talk | contribs) (Publications (*†equal contribution))

     

03:20

(cur | prev) . . (+433). . Jeewoong Lee (talk | contribs) (Publications (*†equal contribution))

     00:40 

Droplet Microfluidics: Diluting Droplets - Andrew Beck‎‎ (3 changes | history) . . (+2,061). . [AB18‎ (3×)]

     

00:40

(cur | prev) . . (+298). . AB18 (talk | contribs)

     

00:34

(cur | prev) . . (+380). . AB18 (talk | contribs)

     

00:31

(cur | prev) . . (+1,383). . AB18 (talk | contribs) (Applications)

19 April 2018

     23:52 

Droplet Microfluidics: Diluting Droplets - Andrew Beck‎‎ (30 changes | history) . . (+4,485). . [AB18‎ (30×)]

     

23:52

(cur | prev) . . (+250). . AB18 (talk | contribs) (References)

     

23:49

(cur | prev) . . (+557). . AB18 (talk | contribs) (Applications)

     

23:14

(cur | prev) . . (+310). . AB18 (talk | contribs)

     

23:05

(cur | prev) . . (+16). . AB18 (talk | contribs)

     

22:48

(cur | prev) . . (-14). . AB18 (talk | contribs) (Digitizing A Gradient Flow)

     

22:46

(cur | prev) . . (0). . AB18 (talk | contribs)

     

22:46

(cur | prev) . . (+173). . AB18 (talk | contribs) (References)

     

22:42

(cur | prev) . . (+1). . AB18 (talk | contribs)

     

22:42

(cur | prev) . . (+20). . AB18 (talk | contribs)

     

22:41

(cur | prev) . . (+4). . AB18 (talk | contribs)

     

22:40

(cur | prev) . . (+10). . AB18 (talk | contribs)

     

22:35

(cur | prev) . . (-3). . AB18 (talk | contribs) (Stepwise Dilution)

     

22:34

(cur | prev) . . (+3). . AB18 (talk | contribs) (Stepwise Dilution)

     

22:34

(cur | prev) . . (+66). . AB18 (talk | contribs) (Stepwise Dilution)

     

22:29

(cur | prev) . . (0). . AB18 (talk | contribs)

     

22:28

(cur | prev) . . (0). . AB18 (talk | contribs) (Stepwise Dilution)

     

22:27

(cur | prev) . . (+23). . AB18 (talk | contribs) (Stepwise Dilution)

     

22:23

(cur | prev) . . (+126). . AB18 (talk | contribs) (Stepwise Dilution)

     

22:15

(cur | prev) . . (+2,089). . AB18 (talk | contribs)

     

21:35

(cur | prev) . . (-322). . AB18 (talk | contribs) (Digitizing A Gradient Flow)

     

21:29

(cur | prev) . . (+705). . AB18 (talk | contribs) (Digitizing Flow)

     

20:46

(cur | prev) . . (+514). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     

20:35

(cur | prev) . . (0). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     

20:35

(cur | prev) . . (+26). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     

20:33

(cur | prev) . . (+6). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     

20:33

(cur | prev) . . (-27). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     

20:32

(cur | prev) . . (-1). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     

20:31

(cur | prev) . . (+1). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     

20:31

(cur | prev) . . (-48). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     

20:06

(cur | prev) . . (0). . AB18 (talk | contribs) (Merging Droplets With An Intersecting Flow)

     23:23  X:People‎ (diff | hist) . . (+185). . ChanEngr (talk | contribs)
     22:27 (Upload log) . . AB18 (talk | contribs) uploaded File:Dilution figure for microfluidics.JPG

     20:39 

Passive Mixing: Hydrodynamic Focusing - Owen O'Connor‎‎ (13 changes | history) . . (+1,688). . [Ttowner‎ (13×)]

     

20:39

(cur | prev) . . (+1,375). . Ttowner (talk | contribs)

     

20:36

(cur | prev) . . (+468). . Ttowner (talk | contribs)

     

20:34

(cur | prev) . . (+2). . Ttowner (talk | contribs)

     

20:33

(cur | prev) . . (+9). . Ttowner (talk | contribs)

     

20:31

(cur | prev) . . (-1,111). . Ttowner (talk | contribs)

     

20:25

(cur | prev) . . (+795). . Ttowner (talk | contribs)

     

20:19

(cur | prev) . . (+36). . Ttowner (talk | contribs)

     

20:16

(cur | prev) . . (-1). . Ttowner (talk | contribs)

     

20:16

(cur | prev) . . (+31). . Ttowner (talk | contribs)

     

20:14

(cur | prev) . . (+30). . Ttowner (talk | contribs)

     

20:10

(cur | prev) . . (+2). . Ttowner (talk | contribs)

     

20:07

(cur | prev) . . (+64). . Ttowner (talk | contribs)

     

20:06

(cur | prev) . . (-12). . Ttowner (talk | contribs)

</wikionly>

<nonwikionly> This page was created using Open Wetware.</nonwikionly>