Difference between revisions of "Karenliu"

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==Welcome to the Liu lab!==
 
==Welcome to the Liu lab!==
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We are interested in signal transduction in developmental biology.
 
We are interested in signal transduction in developmental biology.
  
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
 +
  
 
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
 
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.

Revision as of 04:25, 14 August 2013

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links

Welcome to the Liu lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


<wikionly>

Recent updates to the lab wiki

21 June 2018

     19:15  Renhao Li Lab:Publications‎ (diff | hist) . . (+171). . Renhao Li (talk | contribs) (2018)

     16:28 

Dahlquist:BioQUEST Summer Workshop 2018‎‎ (6 changes | history) . . (+1,464). . [Kam D. Dahlquist‎ (6×)]

     

16:28

(cur | prev) . . (+56). . Kam D. Dahlquist (talk | contribs) (Links: add link to Milk revolution)

     

15:25

(cur | prev) . . (+118). . Kam D. Dahlquist (talk | contribs) (Links: add HHMI)

     

14:43

(cur | prev) . . (+117). . Kam D. Dahlquist (talk | contribs) (Links: add traditional knowledge and scientific knowledge)

     

14:42

(cur | prev) . . (+678). . Kam D. Dahlquist (talk | contribs) (Links: add Sam's resources)

     

13:27

(cur | prev) . . (+387). . Kam D. Dahlquist (talk | contribs) (Links: add Morales paper)

     

11:45

(cur | prev) . . (+108). . Kam D. Dahlquist (talk | contribs) (Links: add case it link)

 m   16:12  User:Puey Ounjai‎ (diff | hist) . . (+87). . Puey Ounjai (talk | contribs) (Contact Info)

     14:10 

Berkmen‎‎ (10 changes | history) . . (+1,654). . [Melanie berkmen‎ (10×)]

     

14:10

(cur | prev) . . (+32). . Melanie berkmen (talk | contribs) (Current Members of the Berkmen Lab)

     

14:09

(cur | prev) . . (+250). . Melanie berkmen (talk | contribs) (Former Members of the Berkmen Lab)

     

14:05

(cur | prev) . . (+263). . Melanie berkmen (talk | contribs) (Current Members of the Berkmen Lab)

     

13:50

(cur | prev) . . (+188). . Melanie berkmen (talk | contribs) (Current Members of the Berkmen Lab)

     

13:48

(cur | prev) . . (+906). . Melanie berkmen (talk | contribs) (Current Members of the Berkmen Lab)

     

13:35

(cur | prev) . . (+149). . Melanie berkmen (talk | contribs) (Former Members of the Berkmen Lab)

     

13:34

(cur | prev) . . (-146). . Melanie berkmen (talk | contribs) (Current Members of the Berkmen Lab)

     

13:34

(cur | prev) . . (+7). . Melanie berkmen (talk | contribs) (Former Members of the Berkmen Lab)

     

13:33

(cur | prev) . . (+976). . Melanie berkmen (talk | contribs) (Former Members of the Berkmen Lab)

     

13:33

(cur | prev) . . (-971). . Melanie berkmen (talk | contribs) (Current Members of the Berkmen Lab)

     13:18  Kim:Publications‎ (diff | hist) . . (-1). . Dhkim21c (talk | contribs)

     11:37 

Chenlab:Lab Members‎‎ (7 changes | history) . . (+501). . [Kaifu Chen‎ (7×)]

     

11:37

(cur | prev) . . (-2). . Kaifu Chen (talk | contribs)

     

11:36

(cur | prev) . . (-78). . Kaifu Chen (talk | contribs)

     

11:31

(cur | prev) . . (+558). . Kaifu Chen (talk | contribs)

     

07:40

(cur | prev) . . (-1). . Kaifu Chen (talk | contribs)

     

07:39

(cur | prev) . . (-12). . Kaifu Chen (talk | contribs)

     

07:38

(cur | prev) . . (+38). . Kaifu Chen (talk | contribs)

     

07:37

(cur | prev) . . (-2). . Kaifu Chen (talk | contribs)

     11:29 (Upload log) . . Kaifu Chen (talk | contribs) uploaded File:LYQ.jpeg
     10:50  Tomlinson:Research‎ (diff | hist) . . (+24). . Ryan E. Tomlinson (talk | contribs) (NSAIDs in Dental Implant Osseointegration)

     00:06 

User:Sayak Mukhopadhyay‎‎ (4 changes | history) . . (+53). . [Sayak Mukhopadhyay‎ (4×)]

     

00:06

(cur | prev) . . (+12). . Sayak Mukhopadhyay (talk | contribs) (Research interests)

     

00:05

(cur | prev) . . (+28). . Sayak Mukhopadhyay (talk | contribs) (Contact Info)

     

00:05

(cur | prev) . . (-34). . Sayak Mukhopadhyay (talk | contribs) (Contact Info)

     

00:02

(cur | prev) . . (+47). . Sayak Mukhopadhyay (talk | contribs) (Education)

20 June 2018

     23:59 

User:Sayak Mukhopadhyay‎‎ (3 changes | history) . . (+26). . [Sayak Mukhopadhyay‎ (3×)]

     

23:59

(cur | prev) . . (+23). . Sayak Mukhopadhyay (talk | contribs) (Contact Info)

     

23:57

(cur | prev) . . (+24). . Sayak Mukhopadhyay (talk | contribs) (Research interests)

     

23:56

(cur | prev) . . (-21). . Sayak Mukhopadhyay (talk | contribs) (Publications)

N    16:21 

Dahlquist:BioQUEST Summer Workshop 2018‎‎ (3 changes | history) . . (+242). . [Kam D. Dahlquist‎ (3×)]

     

16:21

(cur | prev) . . (+105). . Kam D. Dahlquist (talk | contribs) (Links: Cell Biology by the Numbers youtube channel)

     

16:19

(cur | prev) . . (+111). . Kam D. Dahlquist (talk | contribs) (Links: add SNPedia, Gene World)

N    

16:17

(cur | prev) . . (+26). . Kam D. Dahlquist (talk | contribs) (add template and header)

     16:19 

(User creation log). .

[Yar‎ (4×)]

     

16:19

. . User account Tobeyjc (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

09:23

. . User account Tmuzhangcai (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

09:23

. . User account Fgeuna (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

09:23

. . User account Kgarriso (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     16:17  Dahlquist:Protocols‎ (diff | hist) . . (+46). . Kam D. Dahlquist (talk | contribs) (Dry Lab Protocols: add link to BioQUEST 2018)
     15:23  Beauchamp:SurfaceAveraging‎ (diff | hist) . . (+657). . Michael S Beauchamp (talk | contribs)
     15:19  Beauchamp:CorticalSurfaceOverview‎ (diff | hist) . . (0). . Michael S Beauchamp (talk | contribs)
     06:13  Silver: 2018 Meeting Schedule‎ (diff | hist) . . (+260). . PamSilver (talk | contribs)

19 June 2018

     22:35  Dr.HeidiM.Mansour‎ (diff | hist) . . (+137). . Dr. Heidi M. Mansour (talk | contribs)

     15:36 

User:Jszab‎‎ (3 changes | history) . . (+40). . [Jszab‎ (3×)]

     

15:36

(cur | prev) . . (-6). . Jszab (talk | contribs)

     

15:36

(cur | prev) . . (+10). . Jszab (talk | contribs)

     

15:35

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