Difference between revisions of "Karenliu"

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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
 
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
 
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Revision as of 03:45, 14 August 2013

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links

Welcome to the Liu lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.

The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.

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Recent updates to the lab wiki

20 October 2017

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CONJ606:Schedule‎‎ (2 changes | history) . . (+281). . [Maureen E. Hoatlin‎ (2×)]

     

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(cur | prev) . . (+135). . Maureen E. Hoatlin (talk | contribs) (Week-by-Week Schedule Summary)

     

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(cur | prev) . . (+146). . Maureen E. Hoatlin (talk | contribs) (Week-by-Week Schedule Summary)

     15:31  User:Rollinsr‎ (diff | hist) . . (+193). . Rollinsr (talk | contribs) (TZAP)

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Template:LnNotebookRecentChanges2‎‎ (2 changes | history) . . (+98). . [Yar‎ (2×)]

     

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(cur | prev) . . (+16). . Yar (talk | contribs) (more accurate title)

     

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(cur | prev) . . (+82). . Yar (talk | contribs) (use DPL instead of long-dead recent changes filter extension)

     13:27 (Deletion log) . . Yar (talk | contribs) deleted page Subpagerctest(it was just for testing syntax)

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BME100 f2017:Group5 W0800 L4‎‎ (8 changes | history) . . (+65). . [Savina M. Plougmann‎ (3×); Anna Hoge‎ (5×)]

     

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(cur | prev) . . (+3). . Savina M. Plougmann (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (+4). . Savina M. Plougmann (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (-4). . Savina M. Plougmann (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (+1). . Anna Hoge (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+2). . Anna Hoge (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (0). . Anna Hoge (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (+62). . Anna Hoge (talk | contribs) (SNP Information & Primer Design)

     

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(cur | prev) . . (-3). . Anna Hoge (talk | contribs) (Protocol)

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(Upload log). .

[Savina M. Plougmann‎; Anna Hoge‎ (2×)]

     

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. . Savina M. Plougmann (talk | contribs) uploaded File:SavinaPlougmann.jpeg

     

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. . Anna Hoge (talk | contribs) uploaded File:AHprimers1.png

     09:23  Carrico‎ (diff | hist) . . (-305). . Yar (talk | contribs) (use mediawiki markup for images, not raw html)
     09:15 (User creation log) . . User account Msupestka (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

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Beauchamp:DataSharing‎‎ (2 changes | history) . . (+228). . [John Magnotti‎ (2×)]

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     08:02  Peyton: Lab Meeting Schedule Fall 2017‎ (diff | hist) . . (0). . Maria F. Gencoglu (talk | contribs)
     07:49  Min-Ho Kim Lab:Lab Members‎ (diff | hist) . . (-89). . Min-Ho Kim (talk | contribs)

19 October 2017

     21:07  BME100 f2017:Group7 W0800 L4‎ (diff | hist) . . (+977). . Miguel R. Almanza Lopez (talk | contribs) (SNP Information & Primer Design)

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BME100 f2017:Group6 W1030 L4‎‎ (4 changes | history) . . (+1,447). . [Ray Gerard Regorgo‎ (4×)]

     

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(cur | prev) . . (-196). . Ray Gerard Regorgo (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (-3). . Ray Gerard Regorgo (talk | contribs) (OUR TEAM)

     

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(cur | prev) . . (-3). . Ray Gerard Regorgo (talk | contribs) (Research and Development)

     

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(cur | prev) . . (+1,649). . Ray Gerard Regorgo (talk | contribs) (Research and Development)

     15:43  User:Julie A. Fogarty‎ (diff | hist) . . (+46). . Julie A. Fogarty (talk | contribs) (Julie A. Fogarty)

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Rich Lab:Funding‎‎ (2 changes | history) . . (-12). . [Isabel C. Morales‎ (2×)]

     

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(cur | prev) . . (-24). . Isabel C. Morales (talk | contribs)

     14:58  CONJ606:Materials‎ (diff | hist) . . (+685). . Peteral (talk | contribs) (Week 2: Me Myself and I-dentifiers, The Key To Immortality (Persistence))

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User:Peteral‎‎ (2 changes | history) . . (+536). . [Peteral‎ (2×)]

     

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BME100 f2017:Group14 W0800 L4‎‎ (9 changes | history) . . (+9). . [Shae M. Diaz‎ (9×)]

     

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(cur | prev) . . (+8). . Shae M. Diaz (talk | contribs) (Protocol)

     

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(cur | prev) . . (-31). . Shae M. Diaz (talk | contribs) (TEAM MEMBERS)

     

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(cur | prev) . . (+31). . Shae M. Diaz (talk | contribs) (TEAM MEMBERS)

     

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(cur | prev) . . (+1). . Shae M. Diaz (talk | contribs) (TEAM MEMBERS)

     

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(cur | prev) . . (-1). . Shae M. Diaz (talk | contribs) (TEAM MEMBERS)

     

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(cur | prev) . . (+1). . Shae M. Diaz (talk | contribs) (TEAM MEMBERS)

     

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(cur | prev) . . (-3). . Shae M. Diaz (talk | contribs) (TEAM MEMBERS)

 m   14:12  Swartz‎ (diff | hist) . . (+61). . Marcus Rohovie (talk | contribs)
     14:10 (Move log) . . Marcus Rohovie (talk | contribs) moved page Swartz to Swartz:Main

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(Upload log). .

[Shae M. Diaz‎ (3×)]

     

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. . Shae M. Diaz (talk | contribs) uploaded File:100profileshae.JPG

     

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. . Shae M. Diaz (talk | contribs) uploaded File:Shaediaz100.JPG

     

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. . Shae M. Diaz (talk | contribs) uploaded File:BME100ShaeD.JPG

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Klenow Assembly Method: Seamless cloning‎‎ (2 changes | history) . . (-4). . [David M.D. Bailey‎ (2×)]

     

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(cur | prev) . . (-5). . David M.D. Bailey (talk | contribs) (The Klenow Assembly Method (KAM) for the seamless cloning of overlapping double stranded DNA fragments: Very cheap alternative to the Gibson Assembly)

     

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(cur | prev) . . (+1). . David M.D. Bailey (talk | contribs) (The Klenow Assembly Method (KAM) for the seamless cloning of overlapping double stranded DNA fragments: Very cheap alternative to the Gibson Assembly)

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