Difference between revisions of "Karenliu"

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==Welcome to the Liu lab!==
 
==Welcome to the Liu lab!==

Revision as of 04:31, 6 August 2013

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links

Welcome to the Liu lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


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Recent updates to the lab wiki

15 June 2018

     16:52  User:Gareth Trubl‎ (diff | hist) . . (+66). . Gtrubl (talk | contribs)

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The Essential Unknowns/Set Theories‎‎ (3 changes | history) . . (+149). . [Koeng‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (+89). . Koeng (talk | contribs) (Created page with "A placeholder for thoughts and framing of how to figure out what the essential genes are.")

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The Essential Unknowns‎‎ (10 changes | history) . . (+137). . [Koeng‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (-1). . Koeng (talk | contribs) (How to participate)

     

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     12:57 (Upload log) . . Koeng (talk | contribs) uploaded File:JCVI-syn3-cells.jpg(A picture of the JCVI syn3 cell line)
     07:57  Hoatlin:BMB seminar series 2017-2018‎ (diff | hist) . . (+50). . Millejef (talk | contribs)

14 June 2018

     19:47  X-Lab‎ (diff | hist) . . (+80). . ChanEngr (talk | contribs)

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The Essential Unknowns‎‎ (4 changes | history) . . (+445). . [Koeng‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (+186). . Koeng (talk | contribs) (Created page with "This is a placeholder for The Essential Unknowns wiki project. ==Background== [https://example.com The Essential gene set and the Minimal organism?]<br> [https://example.co...")

 m   16:51  User:Korey Griffin‎ (diff | hist) . . (+272). . Korey Griffin (talk | contribs)

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(User creation log). .

[Yar‎ (⧼ntimes⧽)]

     

16:37

. . User account Millejef (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

10:23

. . User account Advancells (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

10:23

. . User account Thembani (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

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User:JernejTurnsek‎‎ (5 changes | history) . . (+171). . [Jernej Turnsek‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (+127). . Jernej Turnsek (talk | contribs) (Resources)

     

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(cur | prev) . . (+15). . Jernej Turnsek (talk | contribs) (Lab)

     

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(cur | prev) . . (+14). . Jernej Turnsek (talk | contribs) (My PhD project in plain English)

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(Upload log). .

[Yar‎; Jernej Turnsek‎]

     

12:05

. . Jernej Turnsek (talk | contribs) uploaded File:Turnsek CV.pdf

     

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. . Yar (talk | contribs) uploaded File:OPB-192-DX.jpg(temp)

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Beauchamp:CorticalSurfaceHCP‎‎ (7 changes | history) . . (+2,639). . [Meghanr‎ (⧼ntimes⧽)]

     

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     10:18 (Deletion log) . . Yar (talk | contribs) deleted page File:OPB-192-DX.jpg(it was just a test)

13 June 2018

     18:22  X-Lab‎ (diff | hist) . . (+299). . ChanEngr (talk | contribs)

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User:JernejTurnsek‎‎ (5 changes | history) . . (-121). . [Jernej Turnsek‎ (⧼ntimes⧽)]

     

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(cur | prev) . . (-53). . Jernej Turnsek (talk | contribs) (Sports)

     

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(cur | prev) . . (-67). . Jernej Turnsek (talk | contribs) (Lab)

     

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(cur | prev) . . (-1). . Jernej Turnsek (talk | contribs) (Creative writing)

     

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(cur | prev) . . (+72). . Jernej Turnsek (talk | contribs) (Creative writing)

     

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(cur | prev) . . (-72). . Jernej Turnsek (talk | contribs) (Science Art)

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McClean:JournalClub‎‎ (2 changes | history) . . (+30). . [Ljiang‎ (⧼ntimes⧽)]

     

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     13:45  Qin‎ (diff | hist) . . (+79). . Yaning (talk | contribs) (News)
     12:03 (User creation log) . . User account Sensor (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎
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