Difference between revisions of "Karenliu"

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==Welcome to the Liu lab!==
 
==Welcome to the Liu lab!==
  
We are interested in signal transduction in developmental biology
 
  
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists.
 
  
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog ''Xenopus laevis'' and the mouse. ''Xenopus'' embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using ''Xenopus'' to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
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We are interested in signal transduction in developmental biology.
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In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
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The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
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==Recent updates to the lab wiki==
 
==Recent updates to the lab wiki==
 
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Revision as of 09:31, 1 June 2007

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links

Welcome to the Liu lab!

We are interested in signal transduction in developmental biology.

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.


The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.


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Recent updates to the lab wiki

18 November 2017

     00:21  Lee:Publications‎ (diff | hist) . . (+58). . Wooin Lee (talk | contribs) (2017)

17 November 2017

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Kim:Publications‎‎ (7 changes | history) . . (+916). . [Dhkim21c‎ (7×)]

     

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     14:20  CAMRI:SeminarSeries‎ (diff | hist) . . (+55). . Michael S Beauchamp (talk | contribs)

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User:Mackenzie K. Kelley/Notebook/Experimental Biochemistry/2017/10/31‎‎ (2 changes | history) . . (+1,197). . [Mackenzie K. Kelley‎ (2×)]

     

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(cur | prev) . . (+950). . Mackenzie K. Kelley (talk | contribs) (Autocreate 2017/10/31 Entry for User:Mackenzie_K._Kelley/Notebook/Experimental_Biochemistry)

     11:22 

(Upload log). .

[Maryam Yamadi‎; Mackenzie K. Kelley‎ (2×); John Navas‎ (2×)]

     

11:22

. . Mackenzie K. Kelley (talk | contribs) uploaded File:Screen Shot 2017-11-17 at 2.20.04 PM.png

     

11:21

. . Mackenzie K. Kelley (talk | contribs) uploaded File:Screen Shot 2017-11-17 at 2.19.45 PM.png

     

09:55

. . John Navas (talk | contribs) uploaded File:BME100WG15 JR3.0 PCRsetup.jpg

     

09:48

. . John Navas (talk | contribs) uploaded File:BME100WG15 JN3.0 PCRsetup.jpg

     

09:23

. . Maryam Yamadi (talk | contribs) uploaded File:10 31.jpg(10_31 Notebook)

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User:Mackenzie K. Kelley/Notebook/Experimental Biochemistry/2017/10/03‎‎ (3 changes | history) . . (+545). . [Mackenzie K. Kelley‎ (3×)]

     

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(cur | prev) . . (+68). . Mackenzie K. Kelley (talk | contribs) (Objective)

     

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(cur | prev) . . (+1). . Mackenzie K. Kelley (talk | contribs) (Results)

     

11:02

(cur | prev) . . (+476). . Mackenzie K. Kelley (talk | contribs) (Results)

     10:47  Yeo lab:meetings‎ (diff | hist) . . (-2). . Yoonyeo (talk | contribs)
     10:34  Lidstrom:Journal Club‎ (diff | hist) . . (+67). . Aaron W. Puri (talk | contribs) (Journal Club Schedule)

     09:57 

BME100 f2017:Group15 W0800 L6‎‎ (2 changes | history) . . (+24). . [John Navas‎ (2×)]

     

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(cur | prev) . . (+12). . John Navas (talk | contribs) (OUR COMPANY)

     

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User:Maryam Yamadi/Notebook/Experimental Biological Chemistry I/2017/11/15‎‎ (2 changes | history) . . (+1,012). . [Maryam Yamadi‎ (2×)]

     

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User:Maryam Yamadi/Notebook/Experimental Biological Chemistry I/2017/11/14‎‎ (2 changes | history) . . (+964). . [Maryam Yamadi‎ (2×)]

     

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User:Maryam Yamadi/Notebook/Experimental Biological Chemistry I/2017/11/08‎‎ (2 changes | history) . . (+1,010). . [Maryam Yamadi‎ (2×)]

     

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User:Maryam Yamadi/Notebook/Experimental Biological Chemistry I/2017/10/31‎‎ (2 changes | history) . . (+968). . [Maryam Yamadi‎ (2×)]

     

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Min-Ho Kim Lab:Lab Members‎‎ (2 changes | history) . . (-22). . [Min-Ho Kim‎ (2×)]

     

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16 November 2017

     19:56  BME100 f2017:Group2 W1030 L6‎ (diff | hist) . . (+540). . Alexis R Crego (talk | contribs) (Feature 1: Consumables)
     18:30 (User creation log) . . User account Javentous (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎
     18:15  User talk:Christine M. R.dorosin‎ (diff | hist) . . (-15). . Yar (talk | contribs) (new username)

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[Yar‎ (3×)]

     

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. . Yar (talk | contribs) restored page User:Christine M. R.dorosin (1 revision) ‎(everything goes to Reicker1 now)

     

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. . Yar (talk | contribs) deleted page User talk:Christine M. R.dorosin(content was: "#REDIRECT User talk:Reicker1", and the only contributor was "Yar" (talk))

     

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. . Yar (talk | contribs) deleted page User:Christine M. R.dorosin(content was: "#REDIRECT User:Reicker1", and the only contributor was "Yar" (talk))

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[Yar‎ (6×)]

     

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. . Yar (talk | contribs) moved page User talk:Christine M. R. Dorosin to User talk:Reicker1(canonicalize)

     

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. . Yar (talk | contribs) moved page User:Christine M. R. Dorosin to User:Reicker1(canonicalize)

     

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. . Yar (talk | contribs) moved page User talk:Reicker1 to User talk:Christine M. R.dorosin without leaving a redirect ‎(preserving history)

     

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. . Yar (talk | contribs) moved page User:Reicker1 to User:Christine M. R.Dorosin without leaving a redirect ‎(preserving history)

     

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. . Yar (talk | contribs) moved page User talk:Christine M. R.dorosin to User talk:Reicker1(Automatically moved page while renaming the user "Christine M. R.dorosin" to "Reicker1")

     

18:06

. . Yar (talk | contribs) moved page User:Christine M. R.dorosin to User:Reicker1(Automatically moved page while renaming the user "Christine M. R.dorosin" to "Reicker1")

     18:06 (User rename log) . . Yar (talk | contribs) renamed user Christine M. R.dorosin (91 edits) to Reicker1(user request)

     18:05 

(User merge log). .

[Yar‎ (2×)]

     

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. . Yar (talk | contribs) Deleted user: Christine1 (17353) ‎

     

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. . Yar (talk | contribs) User Christine1 (17353) merged to Christine M. R.dorosin (15200) ‎

     14:31  User:Peteral‎ (diff | hist) . . (+368). . Peteral (talk | contribs) (Alec's Discussion Questions)
     13:15  CAMRI:SeminarSeries‎ (diff | hist) . . (-5). . Michael S Beauchamp (talk | contribs)
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