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Contact Info

Kaifu Chen
  • Kaifu Chen
  • Dan L. Duncan Cancer Center,Department of Molecular and Cellular Biology, Baylor College of Medicine
  • 1 Baylor Plaza, suite 450A, Houston, Texas,77030.
  • kaifuc at bcm dot edu



Research interest

Based on high throughput DNA sequencing platforms and bioinformatic technologies, we investigate genetic/epigenetic mechanisms in gene function variation and expression regulation, and finally their implication in biological phenotypes, e.g. stem cell differentiation, aging, cancer, and heart diseases.

  1. Genome sequencing: SNP, indel, and structural variation.
  2. RNA-seq or Microarray: gene expression, alternative splicing, LINC RNA.
  3. ChIP- or MNase-seq: nucleosome positioning/occupancy, histone modifications, and other chromatin components, e.g. DNA repair proteins.

Software development

  1. DyChIPS: a software for dyanmic analysis of ChIP-sequencing.
  2. DANPOS: a software for dyanmic analysis of nucleosome position and occupancy.


underlined first or co-first authorship


  1. Chen K,Xi Y, Pan X, Li Z, Kaestner K, Tyler J, Dent S, He X, Li W. DANPOS: Dynamic Analysis of Nucleosome Position and Occupancy by Sequencing. Genome Research (2012) Accepted.
  2. Li Z, Gadue P, Chen K', Tuteja G, Schug J, Li W, Kaestner KH: Foxa2 and H2A.Z Mediate Nucleosome Depletion during Embryonic Stem Cell Differentiation. Cell (2012) Accepted.
  3. Chen K, Wilson MA, Hirsch C, Watson A, Liang S, Lu Y, Li W, Dent S: Stabilization of the Promoter Nucleosomes in Nucleosome Free Region by the Yeast Ssn6-Tup1 Corepressor. Genome Res. (2012) Accepted.
  4. Chen, X., Cui, D., Papusha, A., Zhang, X., Chu, C., Tang, J., Chen, K., Pan, X., Ira, G., The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends (2012). The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends. Nature. doi:10.1038/nature11355
  5. Kuo, A. J., Cheung, P., Chen, K., Zee, B. M., Kioi, M., Lauring, J., Xi, Y., et al. (2011). NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming. Molecular cell, 44(4), 609–620. Elsevier. doi:10.1016/j.molcel.2011.08.042
  6. Barber, M. F., Michishita-Kioi, E., Xi, Y., Tasselli, L., Kioi, M., Moqtaderi, Z., Tennen, R. I.,Chen, K., et al. (2012). SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. doi:10.1038/nature11043
  7. Huang Z, Chen, K., , Zhang J, Li Y, Wang H, Cui D, Tang J, Liu Y, Shi X, Li W, Chen R, Sucgang RS, Pan X: A functional variomics tool for discovering resistance genes and targets of small molecule compounds. Cell Reports (2013) Accepted.
  8. Chen, K., Meng, Q., Ma, L., Liu, Q., Tang, P., Chiu, C., Hu, S., et al. (2008). A novel DNA sequence periodicity decodes nucleosome positioning. Nucleic acids research, 36(19), 6228–6236. doi:10.1093/nar/gkn626
  9. Chen, K., Wang, L., Yang, M., Liu, J., Xin, C., Hu, S., & Yu, J. (2010). Sequence signatures of nucleosome positioning in Caenorhabditis elegans. Genomics, proteomics & bioinformatics, 8(2), 92–102. doi:10.1016/S1672-0229(10)60010-1


  1. Huang Z, Srinivasan S, Zhang J, Chen K', Li Y, Li W, Quiocho FA, Pan X: Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. PLOS Genetics (2012) Accepted
  2. Badeaux, A. I., Yang, Y., Cardenas, K., Vemulapalli, V., Chen K'., Kusewitt, D., Richie, E., et al. (2012). Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. The Journal of biological chemistry, 287(1), 429–437. doi:10.1074/jbc.M111.271163
  3. Huang, Z., Chen K'., Xu, T., Zhang, J., Li, Y., Li, W., Agarwal, A. K., et al. (2011). Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryotic cell, 10(11), 1536–1544. doi:10.1128/EC.05170-11
  4. Ma, L., Chen K'., Meng, Q., Liu, Q., Tang, P., Hu, S., & Yu, J. (2011). An evolutionary analysis of trypanosomatid GP63 proteases. Parasitology research. doi:10.1007/s00436-011-2348-x
  5. Meng, Q., Chen K'., Ma, L., Hu, S., & Yu, J. (2011). A systematic identification of Kolobok superfamily transposons in Trichomonas vaginalis and sequence analysis on related transposases. Journal of genetics and genomics. 38(2), 63–70. doi:10.1016/j.jcg.2011.01.003
  6. Yang, M., Zhang, X., Liu, G., Yin, Y., Chen K'., Yun, Q., Zhao, D., et al. (2010). The complete chloroplast genome sequence of date palm (Phoenix dactylifera L.) PloS one, 5(9), e12762. doi:10.1371/journal.pone.0012762