Josh Michener: Difference between revisions

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__NOTOC__
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=Josh Michener=
=Josh Michener=
==Education==
==Education==
[[Image:JKMpic.jpg|right|thumb]]
[[Image:JKMpic.jpg|right|thumb]]
*2nd year Bioengineering grad student at Caltech
*PhD, 2012, Bioengineering at Caltech
*S.B. 2006, Chemical Engineering and Biology at MIT
*S.B. 2006, Chemical Engineering and Biology at MIT


==Lab history==
==Lab history==
*Grad student in the [[Smolke Lab]] at [http://www.caltech.edu Caltech].
*NRSA Postdoctoral Fellow in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
*Rotated in the Smolke, Arnold, and Elowitz labs at Caltech
*Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Collaborated with Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
*UROP in the [[Endy Lab]] at [http://web.mit.edu/ MIT], January 2005 - January 2006.
*UROP in the Endy Lab at MIT


==Contact Info==
==Contact Info==
Josh Michener<br>
Josh Michener<br>
1200 E. California Blvd.<br>
16 Divinity Ave Room 3082<br>
MC 210-41<br>
Cambridge, MA, 02138<br>
Pasadena, CA, 91125<br>


[[Image:Michener-email.png]]
[[Image:Michener-email.png]]


==Research==
==Research==
My research focuses on applying RNA switches, developed elsewhere in the lab, to provide dynamic control of enzymatic pathways. Specifically, I am using those switches to construct feedback control systems, with the goal of producing a predictable output despite variations in reaction conditions. These control systems can then be used in metabolic engineering to change both the transient and equilibrium responses of a pathway.
My research focuses on the combination of rational and evolutionary methods to build, analyze, and optimize metabolic pathways.


==Past Projects==
==Publications==
*Development of an ''in vivo'' screen for synthetic riboswitches.
*'''Michener JK''', Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. 2012; 109 (47) 19504-19509. [http://www.pnas.org/content/109/47/19504.abstract]
*Design and construction of a [[Endy:Screening plasmid|screening plasmid]] to measure the PoPS transfer curve of a [http://parts.mit.edu BioBricks] device.
*'''Michener JK''' and Smolke CD. High-throughput enzyme evolution in ''Saccharomyces cerevisiae'' using a synthetic RNA switch. Metab Eng. 2012 Jul; 14(4):306-16. [http://www.sciencedirect.com/science/article/pii/S109671761200047X]
 
*'''Michener JK''', Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May; 14(3):212-22. [http://www.sciencedirect.com/science/article/pii/S1096717611000942]
==Interesting papers==
*[[User:Jkm/Feedback|Metabolic control]]
*[[User:Jkm/Caffeine|Caffeine metabolism]]
 
==Random pages==
*[http://brodylab.eng.uci.edu/~jpbrody/reynolds/lowpurcell.html Edward Purcell: Life at Low Reynold's Number]
*[http://www.cs.virginia.edu/~robins/YouAndYourResearch.html Richard Hamming: You and Your Research]
*[[User:Jkm/Alternate_protocols|Alternate page design]]
*[[User:Jkm/sidebar|My sidebar]]
*[[User:Jkm/What not to do|Cautionary tales]]

Revision as of 10:59, 25 March 2013

Josh Michener

Education

  • PhD, 2012, Bioengineering at Caltech
  • S.B. 2006, Chemical Engineering and Biology at MIT

Lab history

  • NRSA Postdoctoral Fellow in the Marx Lab, Harvard Department of Organismic and Evolutionary Biology
  • Graduate student in the Smolke Lab, Caltech/Stanford Bioengineering. Collaborated with Frances Arnold (Caltech ChemE) and Jens Nielsen (Chalmers Systems Bio)
  • UROP in the Endy Lab at MIT

Contact Info

Josh Michener
16 Divinity Ave Room 3082
Cambridge, MA, 02138

Research

My research focuses on the combination of rational and evolutionary methods to build, analyze, and optimize metabolic pathways.

Publications

  • Michener JK, Nielsen J, and Smolke CD. Identification and Treatment of Heme Depletion due to Over-expression of a Lineage of Evolved P450 Monooxygenases. PNAS. 2012; 109 (47) 19504-19509. [1]
  • Michener JK and Smolke CD. High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch. Metab Eng. 2012 Jul; 14(4):306-16. [2]
  • Michener JK, Thodey K, Liang JC, Smolke CD. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng. 2012 May; 14(3):212-22. [3]
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