Difference between revisions of "Jane Johnson Lab:Projects"

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  By determining the downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a, we hope to elucidate a cis-regulatory code for these transcription factors.  In addition, by lineage tracing these factors we hope to assess the ultimate cell fate of the neural subtypes they specify.<br>
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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  By determining the downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a, we hope to elucidate a cis-regulatory code for these transcription factors.  In addition, by lineage tracing these factors, we hope to assess the ultimate cell fate of the neural subtypes they specify.<br>
  
 
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Latest revision as of 10:51, 9 February 2009

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. By determining the downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a, we hope to elucidate a cis-regulatory code for these transcription factors. In addition, by lineage tracing these factors, we hope to assess the ultimate cell fate of the neural subtypes they specify.

Page is in progress...

<gallery> Image:JaneJohnsonLabMath1.jpg|LacZ expression in the Atoh1 domains Image:Nakada.png|GFP expression in the Neurog1 domains Image:Battiste.png|LacZ expression in the Ascl1 domains Image:Glasgow.png|LacZ expression in the Ptf1a domains

<gallery>