Difference between revisions of "Jane Johnson Lab:Projects"

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a.  In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.
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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a.  In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.<br>
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Image:Glasgow.png|LacZ expression in the Ptf1a domains
 
Image:Glasgow.png|LacZ expression in the Ptf1a domains
 
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Revision as of 09:49, 9 February 2009

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a. In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.

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<gallery> Image:JaneJohnsonLabMath1.jpg|LacZ expression in the Atoh1 domains Image:Nakada.png|GFP expression in the Neurog1 domains Image:Battiste.png|LacZ expression in the Ascl1 domains Image:Glasgow.png|LacZ expression in the Ptf1a domains

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