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  1. Lee HG, Minematsu H, Kim KO, Celil Aydemir AB, Shin MJ, Nizami SA, Chung KJ, Hsu AC, Jacobs CR, Lee FY. Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells. Biomaterials. 2011 Dec;32(35):9197-206. PMID: 21899882
  2. Hoey DA, Downs ME, Jacobs CR. The mechanics of the primary cilium: An intricate structure with complex function. J Biomech. 2011 Sep 5.[Epub ahead of print] PMID: 21899847
  3. Hoey DA, Kelly DJ, Jacobs CR. A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. Biochem Biophys Res Commun. 2011 Aug 19;412(1):182-7. PMID: 21810408
  4. Case N, Sen B, Thomas JA, Styner M, Xie Z, Jacobs CR, Rubin J. Steady and oscillatory fluid flows produce a similar osteogenic phenotype. Calcif Tissue Int. 2011 Mar;88(3):189-97. PMID: 21165611
  5. Tummala P, Arnsdorf EJ, Jacobs CR. The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage Commitment. Cell Mol Bioeng. 2010 Sep 1;3(3):207-212. PMID: 20823950
  6. Arnsdorf EJ, Tummala P, Castillo AB, Zhang F, Jacobs CR. The epigenetic mechanism of mechanically induced osteogenic differentiation. J Biomech. 2010 Nov 16;43(15):2881-6. PMID: 20728889
  7. Jacobs CR, Temiyasathit S, Castillo AB. Osteocyte mechanobiology and pericellular mechanics. Annu Rev Biomed Eng. 2010 Aug 15;12:369-400. PMID: 20617941
  8. Castillo AB, Jacobs CR. Mesenchymal stem cell mechanobiology. Curr Osteoporos Rep. 2010 Jun;8(2):98-104. PMID: 20425617]
  9. Temiyasathit S, Jacobs CR. Osteocyte primary cilium and its role in bone mechanotransduction. Ann N Y Acad Sci. 2010 Mar;1192:422-8. PMID: 20392268
  10. Kwon RY, Temiyasathit S, Tummala P, Quah CC, Jacobs CR. Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells. FASEB J. 2010 Aug;24(8):2859-68. PMID: 20371630
  11. Kelly DJ, Jacobs CR. The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells. Birth Defects Res C Embryo Today. 2010 Mar;90(1):75-85. PMID: 20301221
  12. Litzenberger JB, Kim JB, Tummala P, Jacobs CR. Beta1 integrins mediate mechanosensitive signaling pathways in osteocytes. Calcif Tissue Int. 2010 Apr;86(4):325-32. PMID:20213106
  13. Shivaram GM, Kim CH, Batra NN, Yang W, Harris SE, Jacobs CR. Novel early response genes in osteoblasts exposed to dynamic fluid flow. Philos Transact A Math Phys Eng Sci. 2010 Feb 13;368(1912):605-16. PMID: 20047941
  14. Wang L, Shi X, Zhao R, Halloran BP, Clark DJ, Jacobs CR, Kingery WS. Calcitonin-gene-related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-kappaB activation, osteoclastogenesis and bone resorption. Bone. 2010 May;46(5):1369-79. PMID: 19962460
  15. Kim CH, Kim KH, Jacobs CR. Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells. BMC Musculoskelet Disord. 2009 Sep 4;10:109. PMID: 19728893
  16. Arnsdorf EJ, Tummala P, Jacobs CR. Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS One. 2009;4(4):e5388. PMID: 19401766
  17. Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone. 2009 Aug;45(2):309-20. PMID: 19379851
  18. Folgado J, Fernandes PR, Jacobs CR, Pellegrini VD Jr. Influence of femoral stem geometry, material and extent of porous coating on bone ingrowth and atrophy in cementless total hip arthroplasty: an iterative finite element model. Comput Methods Biomech Biomed Engin. 2009 Apr;12(2):135-45. PMID: 19242833
  19. Mishra A, Tummala P, King A, Lee B, Kraus M, Tse V, Jacobs CR. Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Eng Part C Methods. 2009 Sep;15(3):431-5. PMID: 19216642
  20. Arnsdorf EJ, Jones LM, Carter DR, Jacobs CR. The periosteum as a cellular source for functional tissue engineering. Tissue Eng Part A. 2009 Sep;15(9):2637-42. PMID:19207046
  21. Arnsdorf EJ, Tummala P, Kwon RY, Jacobs CR. Mechanically induced osteogenic differentiation--the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci. 2009 Feb 15;122(Pt 4):546-53. PMID: 19174467
  22. Anderson CT, Castillo AB, Brugmann SA, Helms JA, Jacobs CR, Stearns T. Primary cilia: cellular sensors for the skeleton.

Anat Rec (Hoboken). 2008 Sep;291(9):1074-8. PMID: 18727074

  1. Kwon RY, Lew AJ, and Jacobs CR. A microstructurally informed model for the mechanical response of three-dimensional actin networks. Comput Methods Biomech Biomed Engin. 2008 Aug;11(4):407-18. PMID: 18568835
  2. Malone AM, Anderson CT, Stearns T, Jacobs CR. Primary cilia in bone. J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):301. PMID: 18094482
  3. Jacobs CR. Primary cilia. J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):297-8. PMID: 18094479
  4. You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, and Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resportion due to mechanical loading. Bone. 2008 Jan;42(1):172-9. PMID: 17997378
  5. Sabsovich I, Clark JD, Liao G, Peltz G, Lindsey DP, Jacobs CR, Yao W, Guo TZ, and Kingery W. Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan. Bone. 2008 Feb;42(2):439-51. PMID: 17967568
  6. Malone AM, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T, and Jacobs CR. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13325-30. PMID: 17673554
  7. Kwon RY, and Jacobs CR. Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling. J Biomech. 2007;40(14):3162-8. PMID: 17559856
  8. Malone AM, Batra NN, Shivaram G, Kwon RY, You L, Kim CH, Rodriguez J, Jair K, and Jacobs CR. The role of actin cytoskeleton in oscillatory fluid-flow induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol. 2007 May;292(5):C1830-6. PMID: 17251324
  9. Godin LM, Suzuki S, Jacobs CR, Donahue HJ, and Donahue SW. Mechanically induced intracellular calcium waves in osteoblasts demonstrate calcium fingerprints in bone cell mechanotransduction. Biomech Model Mechanobiol. 2007 Nov;6(6):391-8. PMID: 17082961
  10. Kim CH, You L, Yellowley CE, Jacobs CR. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone. 2006 Nov;39(5):1043-7. PMID: 16860618
  11. Rubin J, Rubin C, Jacobs CR. Molecular pathways mediating mechanical signaling in bone. Gene. 2006 Feb 15;367:1-16. PMID: 16361069
  12. Batra NN, Li YJ, Yellowley CE, You L, Malone AM, Kim CH, Jacobs CR. Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech. 2005 Sep;38(9):1909-17. PMID: 16023480
  13. Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, Jacobs CR. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. 2004 Nov;22(6):1283-9. PMID: 15475210
  14. Haut Donahue TL, Genetos DC, Jacobs CR, Donahue HJ, Yellowley CE. Annexin V disruption impairs mechanically induced calcium signaling in osteoblastic cells. Bone. 2004 Sep;35(3):656-63. PMID: 15336601
  15. Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Cycle number and waveform of fluid flow affect bovine articular chondrocytes. Biorheology. 2004;41(3-4):315-22. PMID: 15299264
  16. Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. The sensitivity of tibiofemoral contact pressure to the size and shape of the lateral and medial menisci. J Orthop Res. 2004 Jul;22(4):807-14. PMID: 15183438
  17. Alford AI, Yellowley CE, Jacobs CR, Donahue HJ. Increases in cytosolic calcium, but not fluid flow, affect aggrecan mRNA levels in articular chondrocytes. J Cell Biochem. 2003 Dec 1;90(5):938-44. PMID: 14624453
  18. Reilly GC, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not. Biorheology. 2003;40(6):591-603. PMID: 14610310
  19. Alford AI, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism small star, filled. Bone. 2003 Jul;33(1):64-70. PMID: 12919700
  20. Donahue TL, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport. J Biomech. 2003 Sep;36(9):1363-71. PMID: 12893045
  21. Saunders MM, You J, Zhou Z, Li Z, Yellowley CE, Kunze EL, Jacobs CR, Donahue HJ. Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone. 2003 Apr;32(4):350-6. PMID: 12689677
  22. Donahue SW, Donahue HJ, Jacobs CR. Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow. J Biomech. 2003 Jan;36(1):35-43. PMID: 12485636
  23. Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. How the stiffness of meniscal attachments and meniscal material properties affect tibio-femoral contact pressure computed using a validated finite element model of the human knee joint. J Biomech. 2003 Jan;36(1):19-34. PMID: 12485635
  24. You J, Jacobs CR, Steinberg TH, Donahue HJ. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem. 2002 Dec 13;277(50):48724-9. Epub 2002 Oct 9. PMID: 12376532
  25. Donahue TL, Hull ML, Rashid MM, Jacobs CR. A finite element model of the human knee joint for the study of tibio-femoral contact. J Biomech Eng. 2002 Jun;124(3):273-80. PMID: 12071261
  26. Saunders MM, You J, Trosko JE, Yamasaki H, Li Z, Donahue HJ, Jacobs CR. Gap junctions and fluid flow response in MC3T3-E1 cells. Am J Physiol Cell Physiol. 2001 Dec;281(6):C1917-25. PMID: 11698250
  27. Donahue SW, Jacobs CR, Donahue HJ. Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. Am J Physiol Cell Physiol. 2001 Nov;281(5):C1635-41. PMID: 11600427
  28. Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates cytosolic calcium concentration in bovine articular chondrocytes. J Biomech. 2001 Jan;34(1):59-65. PMID: 11425081
  29. You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem. 2001 Apr 20;276(16):13365-71. Epub 2001 Jan 26. PMID: 11278573
  30. Jacobs CR, Yellowley CE, Nelson DV, Donahue HJ. Analysis of Time-Varying Biological Data Using Rainflow Cycle Counting. Comput Methods Biomech Biomed Engin. 2000;3(1):31-40. PMID: 11264837
  31. Kurokouchi K, Jacobs CR, Donahue HJ. Oscillating fluid flow inhibits TNF-alpha -induced NF-kappa B activation via an Ikappa B kinase pathway in osteoblast-like UMR106 cells. J Biol Chem. 2001 Apr 20;276(16):13499-504. Epub 2000 Nov 28. PMID: 11096064
  32. Black KP, Saunders MM, Stube KC, Moulton MJ, Jacobs CR. Effects of interference fit screw length on tibial tunnel fixation for anterior cruciate ligament reconstruction. Am J Sports Med. 2000 Nov-Dec;28(6):846-9. PMID: 11101107
  33. Paper31 pmid=11036562
  34. Paper32 pmid=10954098
  35. Paper33 pmid=10857219
  36. Paper34 pmid=10850827
  37. Paper35 pmid=10703928
  38. Paper36 pmid=10703922
  39. Paper37 pmid=10541065
  40. Paper38 pmid=10430180
  41. Paper39 pmid=10412989
  42. Paper40 pmid=10352770
  43. Paper41 pmid=10082103
  44. Paper42 pmid=9880053
  45. Paper43 pmid=9252439
  46. Paper44 pmid=9165394
  47. Paper45 pmid=7738054
  48. Paper46 pmid=3708962