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  1. Kwon RY, Lew AJ, and Jacobs CR. A microstructurally informed model for the mechanical response of three-dimensional actin networks. Comput Methods Biomech Biomed Engin. 2008 Aug;11(4):407-18. DOI:10.1080/10255840801888686 | PubMed ID:18568835 | HubMed [Paper1]
  2. You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, and Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone. 2008 Jan;42(1):172-9. DOI:10.1016/j.bone.2007.09.047 | PubMed ID:17997378 | HubMed [Paper2]
  3. Sabsovich I, Clark JD, Liao G, Peltz G, Lindsey DP, Jacobs CR, Yao W, Guo TZ, and Kingery WS. Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan. Bone. 2008 Feb;42(2):439-51. DOI:10.1016/j.bone.2007.09.041 | PubMed ID:17967568 | HubMed [Paper3]
  4. Malone AM, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T, and Jacobs CR. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13325-30. DOI:10.1073/pnas.0700636104 | PubMed ID:17673554 | HubMed [Paper4]
  5. Kwon RY and Jacobs CR. Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling. J Biomech. 2007;40(14):3162-8. DOI:10.1016/j.jbiomech.2007.04.003 | PubMed ID:17559856 | HubMed [Paper5]
  6. Malone AM, Batra NN, Shivaram G, Kwon RY, You L, Kim CH, Rodriguez J, Jair K, and Jacobs CR. The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol. 2007 May;292(5):C1830-6. DOI:10.1152/ajpcell.00352.2005 | PubMed ID:17251324 | HubMed [Paper6]
  7. Godin LM, Suzuki S, Jacobs CR, Donahue HJ, and Donahue SW. Mechanically induced intracellular calcium waves in osteoblasts demonstrate calcium fingerprints in bone cell mechanotransduction. Biomech Model Mechanobiol. 2007 Nov;6(6):391-8. DOI:10.1007/s10237-006-0059-5 | PubMed ID:17082961 | HubMed [Paper7]
  8. Kim CH, You L, Yellowley CE, and Jacobs CR. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone. 2006 Nov;39(5):1043-1047. DOI:10.1016/j.bone.2006.05.017 | PubMed ID:16860618 | HubMed [Paper8]
  9. Rubin J, Rubin C, and Jacobs CR. Molecular pathways mediating mechanical signaling in bone. Gene. 2006 Feb 15;367:1-16. DOI:10.1016/j.gene.2005.10.028 | PubMed ID:16361069 | HubMed [Paper9]
  10. Batra NN, Li YJ, Yellowley CE, You L, Malone AM, Kim CH, and Jacobs CR. Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech. 2005 Sep;38(9):1909-17. DOI:10.1016/j.jbiomech.2004.08.009 | PubMed ID:16023480 | HubMed [Paper10]
  11. Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, and Jacobs CR. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. 2004 Nov;22(6):1283-9. DOI:10.1016/j.orthres.2004.04.002 | PubMed ID:15475210 | HubMed [Paper11]
  12. Haut Donahue TL, Genetos DC, Jacobs CR, Donahue HJ, and Yellowley CE. Annexin V disruption impairs mechanically induced calcium signaling in osteoblastic cells. Bone. 2004 Sep;35(3):656-63. DOI:10.1016/j.bone.2004.04.025 | PubMed ID:15336601 | HubMed [Paper12]
  13. Edlich M, Yellowley CE, Jacobs CR, and Donahue HJ. Cycle number and waveform of fluid flow affect bovine articular chondrocytes. Biorheology. 2004;41(3-4):315-22. PubMed ID:15299264 | HubMed [Paper13]
  14. Haut Donahue TL, Hull ML, Rashid MM, and Jacobs CR. The sensitivity of tibiofemoral contact pressure to the size and shape of the lateral and medial menisci. J Orthop Res. 2004 Jul;22(4):807-14. DOI:10.1016/j.orthres.2003.12.010 | PubMed ID:15183438 | HubMed [Paper14]
  15. Alford AI, Yellowley CE, Jacobs CR, and Donahue HJ. Increases in cytosolic calcium, but not fluid flow, affect aggrecan mRNA levels in articular chondrocytes. J Cell Biochem. 2003 Dec 1;90(5):938-44. DOI:10.1002/jcb.10715 | PubMed ID:14624453 | HubMed [Paper15]
  16. Reilly GC, Haut TR, Yellowley CE, Donahue HJ, and Jacobs CR. Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not. Biorheology. 2003;40(6):591-603. PubMed ID:14610310 | HubMed [Paper16]
  17. Alford AI, Jacobs CR, and Donahue HJ. Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism. Bone. 2003 Jul;33(1):64-70. PubMed ID:12919700 | HubMed [Paper17]
  18. Donahue TL, Haut TR, Yellowley CE, Donahue HJ, and Jacobs CR. Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport. J Biomech. 2003 Sep;36(9):1363-71. PubMed ID:12893045 | HubMed [Paper18]
  19. Saunders MM, You J, Zhou Z, Li Z, Yellowley CE, Kunze EL, Jacobs CR, and Donahue HJ. Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone. 2003 Apr;32(4):350-6. PubMed ID:12689677 | HubMed [Paper19]
  20. Donahue SW, Donahue HJ, and Jacobs CR. Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow. J Biomech. 2003 Jan;36(1):35-43. PubMed ID:12485636 | HubMed [Paper20]
  21. Haut Donahue TL, Hull ML, Rashid MM, and Jacobs CR. How the stiffness of meniscal attachments and meniscal material properties affect tibio-femoral contact pressure computed using a validated finite element model of the human knee joint. J Biomech. 2003 Jan;36(1):19-34. PubMed ID:12485635 | HubMed [Paper21]
All Medline abstracts: PubMed | HubMed