Jacobs

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Welcome to the Cell and Molecular Biomechanics Lab! CMBL is part of the Department of Biomedical Engineering at Columbia University! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation. Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading. This work has applications in developing new therapies to age-related bone loss and osteoporosis. We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice. Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.

News

  • 1/8/2011 CMBL Graduate Students Kristen Lee and Matthew Downs awarded travel grants and Postdoctoral Fellow Julia Chen awarded Best Podium at the 29th meeting of the SPRBM

Kristen Lee presented a paper entitled "TRPV4 is required for mechanotransduction in MC3T3 osteoblasts". Matthew Downs presented a paper entitled "Modeling and analysis of primary cilia under fluid flow". Julia Chen presented a paper entitled "The effect of oscillatory fluid flow on the osteogenic differentiation of human bone marrow stromal cells" on behalf of David Hoey. Abstracts for these papers are available on the SPRBM website (http://www.sprbm.org/assets/bmessprbm2011programbook.pdf)

  • 1/16/2010 CMBL Postdoctoral Fellow David Hoey awarded Best Presentation at the 28th meeting of the SPRBM

Postdoctoral fellow David Hoey was awarded best presentation in the Postdoctoral Category at the 28th meeting of the Society of Physical Regulation in Biology and Medicine. His paper was entitled “Determining the mechanisms of primary cilia bending in response to fluid shear stress”. This paper along with fellow CMBL member, graduate student Jennifer Blundo’s paper are available on the SPRBM website (http://www.pitt.edu/~sprbm/index.html)

  • 9/1/2009 CMBL Postdoc David Hoey awarded IRCSET-Marie Curie International Mobility Fellowship in Science, Engineering and Technology

The objective of the IRCSET-Marie Curie INSPIRE co-funded Scheme is to encourage Ireland-based researchers to avail of a structured period of overseas mobility with associated career development actions, followed by a corresponding return period in Ireland. David will spend two years here in Columbia University after which he will return to Prof. O’Brien's lab in the Royal College of Surgeons in Ireland (http://www.ircset.ie/Default.aspx?tabid=240)

  • 9/1/2009 The CMBL receives New York State Stem Cell Grant

The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load. The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board (NYSTEM). You can look at the lay abstract of the project here.

Recent updates to the lab wiki

19 April 2018

     08:40  Taylor:Publications‎ (diff | hist) . . (+18). . Lynne S. Taylor (talk | contribs) (PUBLICATIONS)
     07:22  Lee:JC‎ (diff | hist) . . (+166). . Wooin Lee (talk | contribs) (Lab meeting schedule)

18 April 2018

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X-Lab‎‎ (4 changes | history) . . (0). . [ChanEngr‎ (4×)]

     

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     13:02  Hydrochloric acid‎ (diff | hist) . . (+1). . Yar (talk | contribs) (typing error from user email)

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(User creation log). .

[Yar‎ (2×)]

     

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. . User account Ally B (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

     

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. . User account Jakob (talk | contribs) was created by Yar (talk | contribs) and password was sent by email ‎

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BIOL478/S18:Microarray Data Analysis‎‎ (24 changes | history) . . (+34,776). . [Kam D. Dahlquist‎ (24×)]

     

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(cur | prev) . . (-70). . Kam D. Dahlquist (talk | contribs) (Gridding and Generating Intensity Data: remove old Brightspace link)

     

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(cur | prev) . . (+1). . Kam D. Dahlquist (talk | contribs) (GenePix Pro Protocol (Steps 1-3): fix Brightspace link to raw data)

     

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(cur | prev) . . (+1,241). . Kam D. Dahlquist (talk | contribs) (Before We Begin: add section on lab notebook)

     

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(cur | prev) . . (0). . Kam D. Dahlquist (talk | contribs) (Background: fix list formatting)

     

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(cur | prev) . . (+108). . Kam D. Dahlquist (talk | contribs) (Background: add GRNsight)

     

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(cur | prev) . . (+3,845). . Kam D. Dahlquist (talk | contribs) (Identifying regulatory transcription factors responsible for observed changes in gene expression (step 10): paste in GRNsight instructions)

     

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(cur | prev) . . (+3,072). . Kam D. Dahlquist (talk | contribs) (Identifying regulatory transcription factors responsible for observed changes in gene expression (step 10): paste in protocol from Biomath modeling, modify for HMO1)

     

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(cur | prev) . . (+114). . Kam D. Dahlquist (talk | contribs) (Clustering and GO Term Enrichment with stem (steps 7-8): add section for step 10)

     

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(cur | prev) . . (-751). . Kam D. Dahlquist (talk | contribs) (Clustering and GO Term Enrichment with stem (steps 7-8): delete comment, emphasize to unzip)

     

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(cur | prev) . . (0). . Kam D. Dahlquist (talk | contribs) (Modified t test for each timepoint: fix formula)

     

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(cur | prev) . . (+52). . Kam D. Dahlquist (talk | contribs) (Sanity Check: Number of genes significantly changed: add label to link)

     

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(cur | prev) . . (+29). . Kam D. Dahlquist (talk | contribs) (Sanity Check: Number of genes significantly changed: add link to xkcd comic)

     

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(cur | prev) . . (-360). . Kam D. Dahlquist (talk | contribs) (replace opi1 with hmo1)

     

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(cur | prev) . . (+18). . Kam D. Dahlquist (talk | contribs) (replace wt with dHMO1)

     

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(cur | prev) . . (+36). . Kam D. Dahlquist (talk | contribs) (Modified t test for each timepoint: replace wt with dHMO1)

     

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(cur | prev) . . (-22). . Kam D. Dahlquist (talk | contribs) (Looking at the raw data: fix links to SGD)

     

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(cur | prev) . . (+61). . Kam D. Dahlquist (talk | contribs) (GenePix Pro Protocol (Steps 1-3): note that this will be demo'd, change opi1 to hmo1)

     

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(cur | prev) . . (+27). . Kam D. Dahlquist (talk | contribs) (Background: steps 1-3 done for you)

     

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(cur | prev) . . (+74). . Kam D. Dahlquist (talk | contribs) (Background: add link for YEASTRACT)

     

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(cur | prev) . . (+15). . Kam D. Dahlquist (talk | contribs) (change dates, mention of Windows 10)

     

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(cur | prev) . . (+27,230). . Kam D. Dahlquist (talk | contribs) (paste in from S18)

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     10:27  Dahlquist:Protocols‎ (diff | hist) . . (+152). . Kam D. Dahlquist (talk | contribs) (Dry Lab Protocols: create link to BIOL 478 Spring 2018 protocol)

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(cur | prev) . . (+71). . Mohammad H. Dezfulian (talk | contribs) (Recent Alumni)

     

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(cur | prev) . . (-30). . Mohammad H. Dezfulian (talk | contribs) (Graduate Students)

     08:35  CAMRI:SeminarSeries‎ (diff | hist) . . (+62). . Lexi E. Crommett (talk | contribs)
     08:00 (Upload log) . . Reinca (talk | contribs) uploaded File:FinalView2.JPG
     01:58  User:Timothee Flutre‎ (diff | hist) . . (+141). . Timothee Flutre (talk | contribs) (Links: add open data repos)

17 April 2018

     23:41  BME100 s2018:Group7 W1030 L6‎ (diff | hist) . . (+454). . Dragos (talk | contribs) (Intro to Computer-Aided Design)

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(cur | prev) . . (+307). . Leaverjill (talk | contribs) (Feature 2: Hardware - PCR Machine & Fluorimeter)

     23:22  BME100 s2018:Group1 W1030 L6‎ (diff | hist) . . (+8). . Erik Halsband (talk | contribs) (Intro to Computer-Aided Design)
     23:18 (Upload log) . . Erik Halsband (talk | contribs) uploaded a new version of File:ClosedFlourimeter.JPG(Re-rendered with updated walls.)