Difference between revisions of "Jacobs"

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Welcome to the Cell and Molecular Biomechanics Lab!  CMBL is part of the [http://bme.columbia.edu Department of Biomedical Engineering]  at [http://www.columbia.edu Columbia University]!  The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation.  Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading.  This work has applications in developing new therapies to age-related bone loss and osteoporosis.  We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice.  Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.
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==News==
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*'''9/15/2009 The CMBL has an open [[Jacobs:Post-doctoral_fellowship_in_Stem_Cell_Biomechanics | post-doctoral fellowship]] in stem cell mechanobiology'''
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* '''9/1/2009 The CMBL receives New York State Stem Cell Grant'''
 
* '''9/1/2009 The CMBL receives New York State Stem Cell Grant'''
 
The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load.  The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board ([http://stemcell.ny.gov/ NYSTEM]).  You can look at the lay abstract of the project [[Jacobs:NYSTEM abstract | here]].
 
The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load.  The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board ([http://stemcell.ny.gov/ NYSTEM]).  You can look at the lay abstract of the project [[Jacobs:NYSTEM abstract | here]].

Revision as of 16:10, 19 January 2010

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Welcome to the Cell and Molecular Biomechanics Lab! CMBL is part of the Department of Biomedical Engineering at Columbia University! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation. Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading. This work has applications in developing new therapies to age-related bone loss and osteoporosis. We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice. Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.

News

  • 9/1/2009 The CMBL receives New York State Stem Cell Grant

The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load. The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board (NYSTEM). You can look at the lay abstract of the project here.

Recent updates to the lab wiki

20 November 2017

     22:56 

BME100 f2017:Group9 W0800 L6‎‎ (9 changes | history) . . (+2,994). . [Renee Chao‎ (2×); Irene Zhang‎ (7×)]

     

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(cur | prev) . . (+8). . Renee Chao (talk | contribs) (Bayesian Statistics)

     

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(cur | prev) . . (+1,046). . Renee Chao (talk | contribs) (Bayesian Statistics)

     

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(cur | prev) . . (+35). . Irene Zhang (talk | contribs) (OUR COMPANY)

     

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(cur | prev) . . (-37). . Irene Zhang (talk | contribs) (OUR COMPANY)

     

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(cur | prev) . . (+2). . Irene Zhang (talk | contribs) (Bayesian Statistics)

     

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(cur | prev) . . (+6). . Irene Zhang (talk | contribs) (LAB 6 WRITE-UP)

     

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(cur | prev) . . (+1,920). . Irene Zhang (talk | contribs) (Feature 1: Consumables)

     

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(cur | prev) . . (+4). . Irene Zhang (talk | contribs) (Feature 2: Hardware - PCR Machine & Fluorimeter)

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User:Sanuja Mohanaraj/Notebook/Experimental Biochemistry 1 Fall 2017/2017/09/12‎‎ (8 changes | history) . . (+509). . [Sanuja Mohanaraj‎ (8×)]

     

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BME100 f2017:Group10 W0800 L6‎‎ (5 changes | history) . . (+2,450). . [Nicole Van Alstine‎ (5×)]

     

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(cur | prev) . . (+2,433). . Nicole Van Alstine (talk | contribs) (LAB 6 WRITE-UP)

     

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BME100 f2017:Group15 W1030 L6‎‎ (11 changes | history) . . (+3,003). . [Kylie I. Mercer‎; Nathan O. Moorman‎ (4×); Kasandra Sanchez‎ (6×)]

     

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(cur | prev) . . (+1,768). . Kylie I. Mercer (talk | contribs) (Feature 2: Hardware - PCR Machine & Fluorimeter)

     

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(cur | prev) . . (+116). . Kasandra Sanchez (talk | contribs) (Feature 1: Consumables)

     

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(cur | prev) . . (+121). . Nathan O. Moorman (talk | contribs) (Intro to Computer-Aided Design)

     

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(cur | prev) . . (+1). . Kasandra Sanchez (talk | contribs) (Feature 1: Consumables)

     

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(cur | prev) . . (+276). . Nathan O. Moorman (talk | contribs) (Intro to Computer-Aided Design)

     

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(cur | prev) . . (+229). . Nathan O. Moorman (talk | contribs) (Intro to Computer-Aided Design)

     

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User:Casey M Culhane/Notebook/EBC Fall 2017/2017/09/13‎‎ (6 changes | history) . . (+961). . [Casey M Culhane‎ (6×)]

     

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(cur | prev) . . (+950). . Casey M Culhane (talk | contribs) (Autocreate 2017/09/13 Entry for User:Casey_M_Culhane/Notebook/EBC_Fall_2017)

     20:44 (Upload log) . . Casey M Culhane (talk | contribs) uploaded File:EBC 9-13-17.pdf
     19:39  BME100 f2017:Group9 W1030 L6‎ (diff | hist) . . (+656). . Nicholas Y. Lee (talk | contribs) (Intro to Computer-Aided Design)

     19:38 

BME100 f2017:Group8 W0800 L6‎‎ (9 changes | history) . . (+1,803). . [Chandler P. Ryder‎; Jinpyo Seo‎; Cassie Riggs‎ (3×); Megan E. Pitts‎ (4×)]

     

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(cur | prev) . . (-2). . Megan E. Pitts (talk | contribs) (Bayesian Statistics)

     

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(cur | prev) . . (-40). . Megan E. Pitts (talk | contribs) (Bayesian Statistics)

     

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(cur | prev) . . (+1,049). . Megan E. Pitts (talk | contribs) (Bayesian Statistics)

     

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(cur | prev) . . (+291). . Megan E. Pitts (talk | contribs) (Bayesian Statistics)

     

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(cur | prev) . . (+145). . Chandler P. Ryder (talk | contribs) (Intro to Computer-Aided Design)

     

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